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    FUNCTIONAL LIGANDS TO OPIOIDS AND OPIOID METABOLITES
    21.
    发明申请
    FUNCTIONAL LIGANDS TO OPIOIDS AND OPIOID METABOLITES 审中-公开

    公开(公告)号：US20180179540A1

    公开(公告)日：2018-06-28

    申请号：US15852941

    申请日：2017-12-22

    Applicant: Base Pair Biotechnologies, Inc.

    Inventor： George W. Jackson

    IPC: C12N15/115

    CPC classification number: C12N15/115 ,  C12N2310/16 ,  C12N2320/13

    Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid metabolites.

    FUNCTIONAL LIGANDS TO TARGET MOLECULES AND METHODS
    22.
    发明申请
    FUNCTIONAL LIGANDS TO TARGET MOLECULES AND METHODS 审中-公开
    目标分子和方法的功能配体

    公开(公告)号：US20170044546A1

    公开(公告)日：2017-02-16

    申请号：US15331833

    申请日：2016-10-22

    Applicant: Base Pair Biotechnologies, Inc.

    Inventor： George W. Jackson

    IPC: C12N15/115 ,  C12N15/10 ,  G01N33/53

    CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12N2310/16 ,  C12N2320/13 ,  C12N2330/31 ,  G01N33/5308 ,  G01N2333/70596 ,  G01N2333/765 ,  G01N2333/79

    Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

    Abstract translation: 本发明涉及功能性配体与靶分子，特别是功能性核酸及其修饰，以及用于同时产生例如多种不同功能生物分子的方法，特别涉及同时产生多种不同功能性核酸的方法。 本发明还涉及与靶分子具有亲和力结合的功能性配体。

    METHOD FOR MULTIPLEXED MOLECULAR DETECTION
    23.
    发明申请
    METHOD FOR MULTIPLEXED MOLECULAR DETECTION 审中-公开
    多重分子检测方法

    公开(公告)号：US20140315727A1

    公开(公告)日：2014-10-23

    申请号：US14257943

    申请日：2014-04-21

    Applicant: Base Pair Biotechnologies, Inc.

    Inventor： George W. Jackson ,  Mark Morris

    IPC: C12N15/10

    CPC classification number: C12N15/1072 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q2521/319 ,  C12Q2537/143 ,  C12Q2563/159

    Abstract: Molecular probes to particular targets may be nucleic acids that may generally possess resistance to degradation when bound to a target molecule. For example, the molecular probes may be generally resistant to nuclease degradation when bound to their target molecules, and generally not resistant to nuclease degradation when unbound to their target molecules. This may be utilized, for example, to selectively degrade unbound molecular probes while preserving the bound molecular probes, which may thus serve as an indication of the presence of their target molecules in a sample.

    Abstract translation: 对特定靶标的分子探针可以是当与靶分子结合时通常可具有降解抗性的核酸。 例如，当结合到其靶分子上时，分子探针通常可以耐核酸酶降解，当与其靶分子结合时通常不耐核酸酶降解。 这可以用于例如选择性降解未结合的分子探针，同时保留结合的分子探针，其因此可以用作样品中其靶分子存在的指示。

    METHODS AND MATERIALS FOR SENSITIVE DETECTION OF TARGET MOLECULES
    27.
    发明申请
    METHODS AND MATERIALS FOR SENSITIVE DETECTION OF TARGET MOLECULES 审中-公开

    公开(公告)号：US20180356408A1

    公开(公告)日：2018-12-13

    申请号：US15777329

    申请日：2016-11-19

    Applicant: Base Pair Biotechnologies, Inc. ,  University of Delaware

    Inventor： George W. Jackson ,  Jeffrey Caplan ,  Kun Huang ,  Blake Meyers

    IPC: G01N33/53 ,  C12N15/115

    CPC classification number: G01N33/5308 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/10

    Abstract: The subcellular localization of mRNA, and small RNA movement and trafficking of these molecules in an organism are important components of cellular and organismal regulation and communication. The next frontier for analysis of RNA will involve analysis at a single-molecule level, and at the subcellular level. This invention relates to methods and materials for sensitive detection of target molecules, particularly to methods and materials for binding or otherwise associating with target molecules and producing a signal for detection of, for example, spatial and/or temporal localization, and more particularly to methods and materials for the above using aptamers which bind to a chromophore or otherwise produce fluorescence or other detectable signal. This invention further relates to aptamers which bind to chromophores such as, for example, biliverdin or other related molecules, and also to such molecules which exhibit fluorescence or other detectable signals.

    FUNCTIONAL LIGANDS TO RICIN
    30.
    发明申请
    FUNCTIONAL LIGANDS TO RICIN 审中-公开

    公开(公告)号：US20170191060A1

    公开(公告)日：2017-07-06

    申请号：US15400912

    申请日：2017-01-06

    Applicant: Base Pair Biotechnologies, Inc.

    Inventor： George W. Jackson

    IPC: C12N15/115 ,  C12N15/10

    CPC classification number: C12N15/115 ,  C12N2310/16

    Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as ricin, particularly to ricin B chain.

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