公开(公告)号：US20200262932A1

公开(公告)日：2020-08-20

申请号：US16777053

申请日：2020-01-30

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Ewald T. J. VAN DEN BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/46 ,  G01N33/68 ,  C07K16/40 ,  C07K16/32 ,  C07K16/28 ,  C07K16/10

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

公开(公告)号：US20190284278A1

公开(公告)日：2019-09-19

申请号：US15744317

申请日：2016-07-14

Applicant: GENMAB A/S

Inventor： Rik RADEMAKER ,  Isil ALTINTAS ,  Patrick ENGELBERTS ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  C07K16/32

Abstract: The present invention relates to humanized or chimeric antibodies binding CD3. It furthermore relates to bispecific antibodies, compositions, pharmaceutical compositions, use of said antibodies in the treatment of a disease, and method of treatment.

公开(公告)号：US20180194845A1

公开(公告)日：2018-07-12

申请号：US15832366

申请日：2017-12-05

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Simone DE HAIJ ,  Thilo RIEDL ,  Rene HOET ,  Ole BAADSGAARD ,  Jan VAN DE WINKEL ,  David SATIJN ,  Paul PARREN ,  Aran Frank LABRIJN ,  Joyce MEESTERS ,  Janine SCHUURMAN ,  Edward N. VAN DEN BRINK

IPC: C07K16/28 ,  C07K16/32 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20180179286A1

公开(公告)日：2018-06-28

申请号：US15832421

申请日：2017-12-05

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Simone DE HAIJ ,  Thilo RIEDL ,  Rene HOET ,  Ole BAADSGAARD ,  Jan VAN DE WINKEL ,  David SATIJN ,  Paul PARREN ,  Aran Frank LABRIJN ,  Joyce MEESTERS ,  Janine SCHUURMAN ,  Edward N. VAN DEN BRINK

IPC: C07K16/28 ,  C07K16/32 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.

公开(公告)号：US20170369590A1

公开(公告)日：2017-12-28

申请号：US15599393

申请日：2017-05-18

Applicant: GENMAB A/S

Inventor： Bart DE GOEIJ ,  Patrick VAN BERKEL ,  Kristin STRUMANE ,  Aran Frank LABRIJN ,  Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/32 ,  A61K45/06 ,  A61K47/68 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6879 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.

公开(公告)号：US20170355767A1

公开(公告)日：2017-12-14

申请号：US15541594

申请日：2016-01-08

Applicant: GENMAB A/S

Inventor： Patrick ENGELBERTS ,  Esther BREIJ ,  Rik RADEMAKER ,  Isil ALTINTAS ,  David SATIJN ,  Sandra VERPLOEGEN ,  Riemke VAN DIJKHUIZEN RADERSMA ,  Edward VAN DEN BRINK ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/28 ,  A61K39/395

CPC classification number: C07K16/2809 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2887 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

Abstract: Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific targeting and T cell-mediated killing of cells that express CD20 is desired.

公开(公告)号：US20160046727A1

公开(公告)日：2016-02-18

申请号：US14830336

申请日：2015-08-19

Applicant: GENMAB A/S

Inventor： Aran Frank LABRIJN ,  Joyce I. MEESTERS ,  Ewald T. J. VAN DEN BREMER ,  Joost J. NEIJSSEN ,  Patrick VAN BERKEL ,  Bart DE GOEIJ ,  Tom VINK ,  Jan VAN DE WINKEL ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/40 ,  G01N33/68 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6854

Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins

Abstract translation: 新型异二聚抗体-Fc的蛋白质，例如双特异性抗体，以及用于产生这种蛋白质的新方法

公开(公告)号：US20210269509A1

公开(公告)日：2021-09-02

申请号：US17253286

申请日：2019-06-24

Applicant: GENMAB A/S

Inventor： Richard HIBBERT ,  Rob DE JONG ,  Aran Frank LABRIJN ,  Arnout GERRITSEN ,  Janine SCHUURMAN ,  Paul PARREN

IPC: C07K16/00 ,  C07K1/22 ,  C07K1/18

Abstract: The present invention relates to a method for controlling the composition of a mixture of two or more different antibodies, such as tow or more different monoclonal antibodies, using chromatography. The mixture is for use as a drug product and the method includes a controlled downstream process for the production of a predetermined ratio of the two or more different antibodies.

公开(公告)号：US20200270366A1

公开(公告)日：2020-08-27

申请号：US16667369

申请日：2019-10-29

Applicant: GENMAB A/S

Inventor： Joost J. NEIJSSEN ,  Joyce I. MEESTERS ,  Bart DE GOEIJ ,  Aran Frank LABRIJN ,  Paul PARREN ,  Janine SCHUURMAN

IPC: C07K16/46 ,  C07K16/10 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K1/113

Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.

公开(公告)号：US20200165352A1

公开(公告)日：2020-05-28

申请号：US16786563

申请日：2020-02-10

Applicant: GENMAB A/S

Inventor： Bart De GOEIJ ,  Grietje ANDRINGA ,  Frank BEURSKENS ,  Janine SCHUURMAN ,  David P.E. SATIJN ,  Tahamtan AHMADI

IPC: C07K16/28 ,  A61P35/00

Abstract: Antibody variants comprising one or more mutations in the Fc region, particularly anti-CD38 antibodies comprising a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino acid residues are numbered according to the EU index.