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公开(公告)号:US20100256126A1
公开(公告)日:2010-10-07
申请号:US12721587
申请日:2010-03-11
申请人: Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
发明人: Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
IPC分类号: A61K31/451 , C07D417/10 , C07D211/62 , C07D401/10 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/541 , A61K31/4545 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/454
CPC分类号: C07D401/10 , A61K31/4409 , A61K31/4465 , C07D211/32 , C07D401/14 , C07D409/14 , C07D413/10 , C07D417/10 , C07D417/14
摘要: The present application relates to compounds of formula wherein the definitions are as described herein. The present compounds are high potential NK-3 receptor antagonists that are useful for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本申请涉及下式的化合物,其中定义如本文所述。 本发明化合物是可用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US08618303B2
公开(公告)日:2013-12-31
申请号:US13342122
申请日:2012-01-02
申请人: Henner Knust , Matthias Nettekoven , Hasane Ratni , Walter Vifian
发明人: Henner Knust , Matthias Nettekoven , Hasane Ratni , Walter Vifian
IPC分类号: C07D401/06 , A61K31/445
CPC分类号: C07D401/06 , C07D401/14 , C07D403/06 , C07D407/06 , C07D413/10
摘要: The invention provides compounds of formula wherein R1, R2, R3, R4, R5, and R6 are as defined herein or a pharmaceutically suitable acid addition salt thereof. The present compounds are high potential NK-3 receptor antagonists useful for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本发明提供下式的化合物,其中R 1,R 2,R 3,R 4,R 5和R 6如本文所定义,或其药学上合适的酸加成盐。 本发明化合物是可用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US08394834B2
公开(公告)日:2013-03-12
申请号:US12856691
申请日:2010-08-16
申请人: Philippe Jablonski , Henner Knust , Matthias Nettekoven , Angelique Patiny-Adam , Hasane Ratni , Claus Riemer
发明人: Philippe Jablonski , Henner Knust , Matthias Nettekoven , Angelique Patiny-Adam , Hasane Ratni , Claus Riemer
IPC分类号: A61K31/4439 , C07D401/14
CPC分类号: C07D401/14 , C07D413/14
摘要: The present invention relates to a compounds of formula I wherein R1, R2, Ar1, Ar2, R′, R″, m, n, and o are defined in the specification or to a pharmaceutically active salt, racemic mixture, enantiomer, optical isomer or to tautomeric form thereof. The present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本发明涉及式I化合物,其中R 1,R 2,Ar 1,Ar 2,R',R“,m,n和o在本说明书中定义或定义为药物活性盐,外消旋混合物,对映体,旋光异构体 或其互变异构形式。 本发明化合物是用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US08324248B2
公开(公告)日:2012-12-04
申请号:US12692680
申请日:2010-01-25
申请人: Henner Knust , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
发明人: Henner Knust , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
IPC分类号: A61K31/445 , C07D401/14
CPC分类号: C07D413/14 , C07D401/12 , C07D401/14
摘要: The present invention relates to a compounds of formula I wherein A, Ar1, Ar2, R1, R2, R3, R4, R5, R6, m, n, o, p, s, t, and u are as defined herein or to a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or a tautomeric form thereof. the present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本发明涉及式I化合物,其中A,Ar1,Ar2,R1,R2,R3,R4,R5,R6,m,n,o,p,s,t和u如本文所定义, 药物活性盐,外消旋混合物,对映体,旋光异构体或其互变异构形式。 本发明化合物是用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US08293770B2
公开(公告)日:2012-10-23
申请号:US12572282
申请日:2009-10-02
申请人: Caterina Bissantz , Philippe Jablonski , Henner Knust , Matthias Nettekoven , Angelique Patiny-Adam , Hasane Ratni , Claus Riemer
发明人: Caterina Bissantz , Philippe Jablonski , Henner Knust , Matthias Nettekoven , Angelique Patiny-Adam , Hasane Ratni , Claus Riemer
IPC分类号: A61K31/40 , A61K31/44 , C07D207/04 , C07D401/02
CPC分类号: C07D207/14 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/10 , C07D405/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D471/04
摘要: The present invention relates to a compound of formula I wherein Ar1, Ar2, R1, R2, R3, n, o, and p are as described herein or to a pharmaceutically active salt, to all stereoisomeric forms, including individual diastereoisomers and enantiomers as well as to racemic and non-racemic mixtures thereof. Compounds of the invention are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本发明涉及式I化合物,其中Ar1,Ar2,R1,R2,R3,n,o和p如本文所述或药物活性盐,涉及所有立体异构体形式,包括单独的非对映异构体和对映异构体 其外消旋和非外消旋混合物。 本发明化合物是用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US20120178761A1
公开(公告)日:2012-07-12
申请号:US13342122
申请日:2012-01-02
申请人: Henner Knust , Matthias Nettekoven , Hasane Ratni , Walter Vifian
发明人: Henner Knust , Matthias Nettekoven , Hasane Ratni , Walter Vifian
IPC分类号: A61K31/454 , C07D207/14 , A61P25/18 , C07D403/06 , A61K31/501 , C07D401/06 , A61K31/40
CPC分类号: C07D401/06 , C07D401/14 , C07D403/06 , C07D407/06 , C07D413/10
摘要: The invention provides compounds of formula wherein R1, R2, R3, R4, R5, and R6 are as defined herein or a pharmaceutically suitable acid addition salt thereof. The present compounds are high potential NK-3 receptor antagonists useful for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本发明提供下式的化合物,其中R 1,R 2,R 3,R 4,R 5和R 6如本文所定义,或其药学上合适的酸加成盐。 本发明化合物是可用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US20090312327A1
公开(公告)日:2009-12-17
申请号:US12482490
申请日:2009-06-11
申请人: Caterina Bissantz , Philippe Jablonski , Henner Knust , Andreas Koblet , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer
发明人: Caterina Bissantz , Philippe Jablonski , Henner Knust , Andreas Koblet , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer
IPC分类号: A61K31/5377 , C07D403/06 , A61K31/497 , A61K31/498 , C07D403/14 , C07D401/06 , A61K31/454 , C07D413/10 , C07D413/14
CPC分类号: C07D207/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10
摘要: The present invention relates to compounds of formula I wherein R1, R2, R3, Ar and n are as defined herein and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers or tautomeric forms thereof. The compounds can be used for the treatment of depression, anxiety or schizophrenia.
摘要翻译: 本发明涉及其中R 1,R 2,R 3,Ar和n如本文所定义的药物活性盐,外消旋混合物,对映异构体,旋光异构体或其互变异构形式的式I化合物。 该化合物可用于治疗抑郁,焦虑或精神分裂症。
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公开(公告)号:US08404679B2
公开(公告)日:2013-03-26
申请号:US13452981
申请日:2012-04-23
申请人: Caterina Bissantz , Philippe Jablonski , Henner Knust , Andreas Koblet , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer
发明人: Caterina Bissantz , Philippe Jablonski , Henner Knust , Andreas Koblet , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer
IPC分类号: A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/541 , C07D207/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/06 , A61K31/454 , A61K31/501 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06
CPC分类号: C07D207/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10
摘要: The present invention relates to compounds of formula I wherein R1, R2, R3, Ar and n are as defined herein and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers or tautomeric forms thereof. The compounds can be used for the treatment of depression, anxiety or schizophrenia.
摘要翻译: 本发明涉及其中R 1,R 2,R 3,Ar和n如本文所定义的药物活性盐,外消旋混合物,对映异构体,旋光异构体或其互变异构形式的式I化合物。 这些化合物可用于治疗抑郁,焦虑或精神分裂症。
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公开(公告)号:US08324250B2
公开(公告)日:2012-12-04
申请号:US12721587
申请日:2010-03-11
申请人: Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
发明人: Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
IPC分类号: A61K31/445 , C07D413/02
CPC分类号: C07D401/10 , A61K31/4409 , A61K31/4465 , C07D211/32 , C07D401/14 , C07D409/14 , C07D413/10 , C07D417/10 , C07D417/14
摘要: The present application relates to compounds of formula wherein the definitions are as described herein. The present compounds are high potential NK-3 receptor antagonists that are useful for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本申请涉及下式的化合物,其中定义如本文所述。 本发明化合物是可用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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公开(公告)号:US08318749B2
公开(公告)日:2012-11-27
申请号:US12614474
申请日:2009-11-09
申请人: Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
发明人: Henner Knust , Anja Limberg , Matthias Nettekoven , Hasane Ratni , Claus Riemer , Walter Vifian
IPC分类号: A61K31/517 , C07D239/70 , C07D401/04
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
摘要: The present invention relates to a compounds of formula I wherein R1, R2, R3, R4, R5, and n are as defined herein and to a pharmaceutically active salt, a racemic mixture, an enantiomer, an optical isomer or a tautomeric form thereof. The present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
摘要翻译: 本发明涉及式Ⅰ化合物,其中R 1,R 2,R 3,R 4,R 5和n如本文所定义,并且涉及药物活性盐,外消旋混合物,对映异构体,旋光异构体或其互变异构形式。 本发明化合物是用于治疗抑郁症,疼痛,精神病,帕金森病,精神分裂症,焦虑和注意缺陷多动障碍(ADHD)的高潜力NK-3受体拮抗剂。
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