公开(公告)号：US20130029929A1

公开(公告)日：2013-01-31

申请号：US13609614

申请日：2012-09-11

申请人： Michael Joseph Sofia ,  Jinfa Du ,  Peiyuan Wang ,  Dhanapalan Nagarathnam

发明人： Michael Joseph Sofia ,  Jinfa Du ,  Peiyuan Wang ,  Dhanapalan Nagarathnam

IPC分类号： C07H19/06 ,  A61P31/16 ,  A61P31/14 ,  A61K31/7072 ,  C07H1/00

CPC分类号： A61K31/7072 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06 ,  C07D417/14 ,  C07H17/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/20 ,  Y02A50/463

摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

公开(公告)号：US07964580B2

公开(公告)日：2011-06-21

申请号：US12053015

申请日：2008-03-21

申请人： Michael Joseph Sofia ,  Jinfa Du ,  Peiyuan Wang

发明人： Michael Joseph Sofia ,  Jinfa Du ,  Peiyuan Wang

IPC分类号： A01N43/04 ,  A61K31/70

CPC分类号： A61K31/7072 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06 ,  C07D417/14 ,  C07H17/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/20 ,  Y02A50/463

摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。