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公开(公告)号：US08580765B2
公开(公告)日：2013-11-12
申请号：US13609614
申请日：2012-09-11
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
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公开(公告)号：US20110257122A1
公开(公告)日：2011-10-20
申请号：US13099671
申请日：2011-05-03
申请人： Michael Joseph Sofia , Jinfa Du , Peiyuan Wang
发明人： Michael Joseph Sofia , Jinfa Du , Peiyuan Wang
IPC分类号： A61K31/7076 , A61P31/14 , C07H19/207 , C07H19/10 , A61K31/7068
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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公开(公告)号：US08334270B2
公开(公告)日：2012-12-18
申请号：US13099671
申请日：2011-05-03
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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公开(公告)号：US08716262B2
公开(公告)日：2014-05-06
申请号：US12645765
申请日：2009-12-23
CPC分类号： C07H19/20
摘要： A nucleoside compound having activity against hepatitis C virus is disclosed.
摘要翻译： 公开了具有抗丙型肝炎病毒活性的核苷化合物。
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公开(公告)号：US20130029929A1
公开(公告)日：2013-01-31
申请号：US13609614
申请日：2012-09-11
IPC分类号： C07H19/06 , A61P31/16 , A61P31/14 , A61K31/7072 , C07H1/00
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
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公开(公告)号：US07964580B2
公开(公告)日：2011-06-21
申请号：US12053015
申请日：2008-03-21
申请人： Michael Joseph Sofia , Jinfa Du , Peiyuan Wang
发明人： Michael Joseph Sofia , Jinfa Du , Peiyuan Wang
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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公开(公告)号：US08716263B2
公开(公告)日：2014-05-06
申请号：US12645821
申请日：2009-12-23
申请人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
发明人： Byoung-Kwon Chun , Jinfa Du , Suguna Rachakonda , Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Wonsuk Chang , Hai-Ren Zhang , Dhanapalan Nagarathnam
CPC分类号： C07H19/20 , C07H1/00 , C07H5/02 , C07H15/04 , C07H19/167 , C07H19/213 , Y02P20/55
摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.
摘要翻译： 制备核苷衍生物的氨基磷酸酯前药或环磷酸酯前药的方法，其为化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或其结晶形式。
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公开(公告)号：US08569478B2
公开(公告)日：2013-10-29
申请号：US12067995
申请日：2006-09-26
申请人： Jinfa Du , Phillip Furman , Michael Joseph Sofia
发明人： Jinfa Du , Phillip Furman , Michael Joseph Sofia
IPC分类号： C07H19/04 , C07H19/20 , C07H19/10 , C07H19/048 , C07H19/22 , C07H19/00 , C07D239/00 , C07D239/02 , C07D473/00 , C07F9/02
摘要： Compounds, methods and compositions for treating a host infected with human immunodeficiency virus and hepatitis B virus comprising administering an effective amount of a described 4′-C-substituted β-D- and β-L-nucleoside or a pharmaceutically acceptable salt or prodrug thereof, are provided.
摘要翻译： 用于治疗感染人免疫缺陷病毒和乙型肝炎病毒的宿主的化合物，方法和组合物，包括施用有效量的所述4'-C-取代的β-D-和β-L-核苷或其药学上可接受的盐或前药 ，提供。
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公开(公告)号：US20150018300A1
公开(公告)日：2015-01-15
申请号：US14332255
申请日：2014-07-15
申请人： Jinfa Du , Michael Joseph Sofia
发明人： Jinfa Du , Michael Joseph Sofia
IPC分类号： C07H19/207 , A61K31/7076 , A61K45/06
CPC分类号： C07H19/207 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K31/708 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H23/00 , Y02A50/385 , Y02A50/463
摘要： Disclosed herein are 2′-spiro-nucleosides and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus.
摘要翻译： 本文公开了可用于治疗感染丙型肝炎病毒或登革热病毒的受试者的2'-螺 - 核苷及其衍生物。
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