公开(公告)号：US20210023080A1

公开(公告)日：2021-01-28

申请号：US16639486

申请日：2018-09-05

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Fabio RANCATI ,  Gurdip BHALAY ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  Christine EDWARDS ,  Patrizia TISSELLI

IPC: A61K31/4995 ,  A61K9/00 ,  A61K31/496 ,  C07D471/04 ,  A61K31/437 ,  C07D487/08

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20200079774A1

公开(公告)日：2020-03-12

申请号：US16656842

申请日：2019-10-18

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Anna Maria CAPELLI ,  David Edward CLARK ,  Patrizia TISSELLI ,  Christine EDWARDS ,  Gurdip BHALAY ,  Arnaud Jean Francois Auquste CHEGUILLAUME

IPC: C07D471/04 ,  A61K9/00 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  C07D471/08 ,  C07D498/04 ,  C07D519/00 ,  C07D487/04

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20180016267A1

公开(公告)日：2018-01-18

申请号：US15647901

申请日：2017-07-12

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Andrea Rizzi ,  Laura Carzaniga ,  Ian Linney ,  Chris Knight ,  Wolfgang Schmidt

IPC: C07D409/14 ,  A61K45/06 ,  A61M16/14 ,  A61K31/4709 ,  A61K9/00 ,  A61K31/506 ,  A61K31/497 ,  C07D401/14 ,  A61M15/00

CPC classification number: C07D409/14 ,  A61K9/0073 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  A61M15/009 ,  A61M16/14 ,  A61M2202/064 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/08 ,  C07D495/04

Abstract: Compounds of formula I defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

公开(公告)号：US20170158694A1

公开(公告)日：2017-06-08

申请号：US15364669

申请日：2016-11-30

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Ian LINNEY

IPC: C07D471/08 ,  C07D401/12 ,  A61K31/4704 ,  C07D409/12 ,  C07D409/14 ,  A61K45/06 ,  C07D405/14

CPC classification number: C07D471/08 ,  A61K31/4704 ,  A61K31/4709 ,  A61K45/06 ,  C07D401/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

Abstract: Compounds of formula (I), defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

公开(公告)号：US20160235734A1

公开(公告)日：2016-08-18

申请号：US15040382

申请日：2016-02-10

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Andrea RIZZI ,  Laura CARZANIGA ,  Ian LINNEY ,  Chris KNIGHT ,  Wolfgang SCHMIDT

IPC: A61K31/4704 ,  A61K9/00 ,  C07D401/12 ,  A61K31/4709 ,  C07D409/14 ,  C07D498/10 ,  C07D215/227 ,  C07D401/14 ,  A61K31/496 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K45/06 ,  C07D453/02

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/227 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

Abstract translation: 式I定义的化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于治疗支气管阻塞性和炎性疾病。

公开(公告)号：US20140163066A1

公开(公告)日：2014-06-12

申请号：US14098662

申请日：2013-12-06

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Fabio RANCATI ,  Ian Linney ,  Chris Knight ,  Wolfgang Schmidt

IPC: A61K31/4709 ,  A61M16/14 ,  A61M15/00 ,  C07D453/02 ,  A61K45/06

CPC classification number: C07D453/02 ,  A61K9/0073 ,  A61K31/4709 ,  A61K31/496 ,  A61K45/06 ,  A61M15/0045 ,  A61M15/009 ,  A61M16/14

Abstract: Compounds of formula (I) defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

Abstract translation: 本文定义的式（I）化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于预防和/或治疗支气管阻塞性或炎性疾病。