公开(公告)号：US20170119753A1

公开(公告)日：2017-05-04

申请号：US15404897

申请日：2017-01-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Andrea RIZZI ,  Laura CARZANIGA ,  Ian LINNEY ,  Chris KNIGHT ,  Wolfgang SCHMIDT

IPC: A61K31/4709 ,  A61K31/5386 ,  A61K31/496 ,  A61K9/00 ,  A61K31/4704

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/227 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

公开(公告)号：US20240391936A1

公开(公告)日：2024-11-28

申请号：US18283861

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Andrea RIZZI ,  Nicoió IOTTI ,  Fabio RANCATI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  David Edward CLARK ,  Toby Matthew Grover MULLINS ,  Keith Christopher KNIGHT ,  Ben Paul WHITTAKER ,  Stefano LEVANTO

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240217967A1

公开(公告)日：2024-07-04

申请号：US18283851

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Nicolò IOTTI ,  Keith Christopher KNIGHT ,  Toby Matthew Grover MULLINS ,  Anna KARAWAJCZYK ,  Ben Paul WHITTAKER

IPC: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20160346271A1

公开(公告)日：2016-12-01

申请号：US15168466

申请日：2016-05-31

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Ian LINNEY ,  Wolfgang SCHMIDT ,  Michael BARNES ,  Chris KNIGHT

IPC: A61K31/4709 ,  A61M16/14 ,  A61M15/00 ,  C07D453/02 ,  A61K9/00

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61M15/009 ,  A61M16/14 ,  A61M2202/064 ,  C07D453/02

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating diseases of the respiratory tract.

Abstract translation: 式I定义的化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于治疗呼吸道疾病。

公开(公告)号：US20240425482A1

公开(公告)日：2024-12-26

申请号：US18702454

申请日：2022-10-17

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Eleonora GHIDINI ,  Nicolò IOTTI ,  Roberta MAZZUCATO ,  Stefano LEVANTO ,  Ben Paul WHITTAKER

IPC: C07D401/14 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/10

Abstract: The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240199635A1

公开(公告)日：2024-06-20

申请号：US18283867

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZi ,  Keith Christopher KNIGHT ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS ,  Ben Paul WHITTAKER

IPC: C07D495/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541

CPC classification number: C07D495/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240190847A1

公开(公告)日：2024-06-13

申请号：US18283855

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS

IPC: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

Abstract: The present invention relates to compounds of general formula (I) inhibiting DDR1 and DDR2. Particularly, the invention relates to compounds that are indoline derivatives, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.

公开(公告)号：US20230227447A1

公开(公告)日：2023-07-20

申请号：US17927762

申请日：2021-05-24

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Bartosz Pawel GUT

IPC: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting DDR1 and DDR2, particularly the invention relates to compounds that are benzylamine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.

公开(公告)号：US20170158694A1

公开(公告)日：2017-06-08

申请号：US15364669

申请日：2016-11-30

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Ian LINNEY

IPC: C07D471/08 ,  C07D401/12 ,  A61K31/4704 ,  C07D409/12 ,  C07D409/14 ,  A61K45/06 ,  C07D405/14

CPC classification number: C07D471/08 ,  A61K31/4704 ,  A61K31/4709 ,  A61K45/06 ,  C07D401/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

Abstract: Compounds of formula (I), defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

公开(公告)号：US20160235734A1

公开(公告)日：2016-08-18

申请号：US15040382

申请日：2016-02-10

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Andrea RIZZI ,  Laura CARZANIGA ,  Ian LINNEY ,  Chris KNIGHT ,  Wolfgang SCHMIDT

IPC: A61K31/4704 ,  A61K9/00 ,  C07D401/12 ,  A61K31/4709 ,  C07D409/14 ,  C07D498/10 ,  C07D215/227 ,  C07D401/14 ,  A61K31/496 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K45/06 ,  C07D453/02

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/227 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

Abstract translation: 式I定义的化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于治疗支气管阻塞性和炎性疾病。