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公开(公告)号：US08278315B2
公开(公告)日：2012-10-02
申请号：US10651305
申请日：2003-08-28
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
IPC: A61K31/506 , A61K31/35 , A61K33/24 , A61K31/282
CPC classification number: A61K41/0085 , A61K31/282 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K41/0038
Abstract: A method of treating living mammals including humans uses x-rays to disrupt DNA in malfunctioning cells such as cancerous or tumorous cells. A compound comprising a pre-selected element is administered to the mammal so that the compound associates with DNA. Then a localized region of cells which contains the malfunctioning cells is irradiated with line emission x-rays of an energy selected to cause emission of Auger electrons from the pre-selected element of the compound to disrupt DNA proximate to the irradiated pre-selected element. A kit useful for the treatment comprises an x-ray tube capable of emitting monochromatic line emission x-rays and a compound which associates with DNA and has an element which when irradiated emits said Auger electrons.
Abstract translation: 治疗包括人在内的活的哺乳动物的方法使用X射线来破坏诸如癌细胞或肿瘤细胞的细胞中的DNA。 向哺乳动物施用包含预先选择的元件的化合物，使得化合物与DNA结合。 然后用含有能量的线发射x射线照射含有故障细胞的细胞的局部区域，以引起来自化合物的预先选择的元件的俄歇电子的发射，以破坏靠近被照射的预先选择的元件的DNA。 可用于治疗的试剂盒包括能够发射单色线发射x射线的X射线管和与DNA缔合的化合物，并且具有当照射时发射所述俄歇电子的元素。
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公开(公告)号：US07180981B2
公开(公告)日：2007-02-20
申请号：US10960445
申请日：2004-10-07
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
IPC: H01J35/08
CPC classification number: H01J35/08 , H01J2235/081 , H01J2235/087 , H01J2235/088
Abstract: The invention relates to targets for an X-ray transmission tube (9); to a high efficiency, high excitation energy X-ray transmission tube; to combinations of the targets and high efficiency X-ray transmission tubes; and applications for utilizing such X-ray tubes. The target comprises two or more different thin foils (1) or at least two foils of the same material but different foil thickness on separate areas of a substantially planar substrate which is substantially transparent to X-rays. The target may also comprise at least two different foils (2, 3) layered sequentially one of the other, wherein X-rays are produced when an electron beam impinges the foil closest to the source fo the electron beam; wherein the energy of the electron beam is selectively changed to produce X-rays of a least one preselected energy characteristic of at least one of the foils.
Abstract translation: 本发明涉及X射线透射管（9）的靶。 以高效率，高激发能X射线传输管; 目标和高效X射线透射管的组合; 以及利用这种X射线管的应用。 目标包括两个或多个不同的薄箔（1）或至少两个相同材料的箔，但在基本上平坦的基底的对X射线基本透明的分开的区域上具有不同的箔厚度。 目标还可以包括至少两个不同的箔（2,3），其彼此分层地分层，其中当电子束撞击最靠近电子束的源的箔时，产生X射线; 其中电子束的能量被选择性地改变以产生至少一个箔的至少一个预选能量特性的X射线。
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公开(公告)号：US20060169969A1
公开(公告)日：2006-08-03
申请号：US11345143
申请日：2006-02-01
Applicant: Chia-Gee Wang , Adam Filios
Inventor： Chia-Gee Wang , Adam Filios
IPC: H01L29/06
CPC classification number: H01J1/308 , H01J9/022 , H01J2223/34 , H01J2235/062
Abstract: A bandgap cascade cold cathode is obtained by constructing a wide bandgap Si/C superlattice thin film; depositing Si on the epitaxial silicon surface under CVD or ALD; depositing on the Si/C surface a first metal effective to form a metal-silicide electrode; etching away the silicon substrate to form an effectively smooth Si/C surface thereon; coating the effectively smooth Si/C surface with a thicker second effective metal to form a Schottky electrode surface on which a layer of about 200 nm Pt or Au is coated with edges masked off and welded onto a Cu electrode disc as a heat sink. During avalanche multiplication under reverse bias over the Si/C layer, the bandgap energy cascades from the Schottky electrode to the sink electrode and is used to balance against the work function of the sink electrode, thereby allowing the sink electrode to function as a cold cathode emitter at a reduced applied external field.
Abstract translation: 通过构造宽带隙Si / C超晶格薄膜获得带隙级联冷阴极; 在CVD或ALD下在外延硅表面上沉积Si; 在Si / C表面上沉积有效形成金属硅化物电极的第一金属; 蚀刻掉硅衬底以在其上形成有效平滑的Si / C表面; 用更厚的第二有效金属涂覆有效平滑的Si / C表面以形成肖特基电极表面，其上涂覆有约200nm Pt或Au的层被边缘掩蔽并焊接到作为散热器的Cu电极盘上。 在Si / C层的反向偏置下的雪崩倍增期间，带隙能量从肖特基电极到吸收电极串联，并用于与吸收电极的功函数平衡，从而允许吸收电极用作冷阴极 发射器在减小的外部场。
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公开(公告)号：US20050185756A1
公开(公告)日：2005-08-25
申请号：US11065595
申请日：2005-02-24
Applicant: Chia-Gee Wang , Thomas Vullo
Inventor： Chia-Gee Wang , Thomas Vullo
CPC classification number: A61B6/502
Abstract: A mammography method images breast tissue with an end window X-ray transmission tube to detect the presence of neovascular micro-vessels as defining vascular structure associated with a suspect tumorous mass. A kit therefor has a high-efficiency, end window X-ray transmission tube and a supply of a contrast agent.
Abstract translation: 乳房X线摄影法利用端窗X射线透射管对乳房组织进行成像，以检测新生血管微血管的存在，以定义与可疑肿瘤组织相关的血管结构。 其工具包具有高效率的端窗X射线透射管和供应的造影剂。
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Patent Agency Ranking
公开(公告)号：US20050080019A1
公开(公告)日：2005-04-14
申请号：US10651305
申请日：2003-08-28
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
IPC: A01N43/04 , A61K31/70 , A61N20060101
CPC classification number: A61K41/0085 , A61K31/282 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K41/0038
Abstract: A method of treating living mammals including humans uses x-rays to disrupt DNA in malfunctioning cells such as cancerous or tumorous cells. A compound comprising a pre-selected element is administered to the mammal so that the compound associates with DNA. Then a localized region of cells which contains the malfunctioning cells is irradiated with line emission x-rays of an energy selected to cause emission of Auger electrons from the pre-selected element of the compound to disrupt DNA proximate to the irradiated pre-selected element. A kit useful for the treatment comprises an x-ray tube capable of emitting monochromatic line emission x-rays and a compound which associates with DNA and has an element which when irradiated emits said Auger electrons.
Abstract translation: 治疗包括人在内的活的哺乳动物的方法使用X射线来破坏诸如癌细胞或肿瘤细胞的细胞中的DNA。 向哺乳动物施用包含预先选择的元件的化合物，使得化合物与DNA结合。 然后用含有能量的线发射x射线照射含有故障细胞的细胞的局部区域，以引起来自化合物的预先选择的元件的俄歇电子的发射，以破坏靠近被照射的预先选择的元件的DNA。 可用于治疗的试剂盒包括能够发射单色线发射x射线的X射线管和与DNA缔合的化合物，并且具有当照射时发射所述俄歇电子的元素。
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公开(公告)号：US5044001A
公开(公告)日：1991-08-27
申请号：US541261
申请日：1990-06-20
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
IPC: G01N23/02 , G01N23/223 , G21K7/00 , H01J35/00 , H01J35/14 , H01J37/256
CPC classification number: H01J37/256 , G01N23/02 , G01N23/223 , G21K7/00 , H01J35/00 , H01J35/14 , G01N2223/076 , H01J2235/087
Abstract: A method of investigating materials, especially biological specimens, utilizes a focused accelerated beam of electrons within an evacuated chamber, striking a metal foil within the chamber and exposing a specimen outside the evacuated chamber to x-rays generated in the metal foil. The apparatus of the invention functions as an x-ray microscope and in a preferred embodiment, as a scanning x-ray microscope.
Abstract translation: 研究材料，特别是生物样品的方法利用在真空室内聚焦的加速电子束，撞击室内的金属箔，并将抽真空室外的样品暴露于在金属箔中产生的X射线。 本发明的装置用作X射线显微镜，在优选实施例中，作为扫描X射线显微镜。
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公开(公告)号：US4454233A
公开(公告)日：1984-06-12
申请号：US331859
申请日：1981-12-17
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
IPC: G01N33/532 , G01N33/54
CPC classification number: G01N33/532
Abstract: An immunoassay method for measurement of the content of a target antigen or antibody in a fluid or tissue specimen comprises reacting the target with reagent antibody or antigen which forms a complex with the target and is carried by small tagged mobile units having tagging elements or compounds which are unassociated chemically with said reagent and are protected against reaction with the target and the biological and chemical environment of the assay. The tagged mobile units bearing formed complexes are measured by spectroscopic detection. Preferably the small, tagged mobile units, such as latex particles, are of a size smaller than 0.8 .mu.m. The tagged complexes which are formed may be measured by spectrophotometric detection or by mass spectrometry. Different target antigens or antibodies can be assayed simultaneously by employing different tagged mobile units, and the mobile units with the tagging elements can be recovered for disposal or for reuse.
Abstract translation: 用于测量流体或组织标本中靶抗原或抗体含量的免疫测定方法包括使靶与试剂抗体或与靶标形成复合物的抗原反应，并由具有标记元件或化合物的小标记移动单元携带， 与所述试剂未化学相关，并且被保护免受与靶标的反应和测定的生物和化学环境的反应。 通过光谱检测测量带有形成的复合物的标记的移动单元。 优选地，小的标记的移动单元，例如胶乳颗粒，其尺寸小于0.8μm。 形成的标记的复合物可以通过分光光度检测或质谱法测量。 可以通过使用不同标记的移动单元同时测定不同的靶抗原或抗体，并且具有标记元件的移动单元可以被回收以供处理或重新使用。
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公开(公告)号：US4425423A
公开(公告)日：1984-01-10
申请号：US419405
申请日：1982-09-17
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
CPC classification number: G03F7/2039 , G03C5/16 , Y10S430/143 , Y10S430/168
Abstract: An Auger microlithography process wherein a beam of substantially monochromatic X-rays is passed through a photomask to induce Auger electrons from a selected atomic element within a photosensitive layer which Auger electrons act on a material in that layer to cause a physicochemical change thereof and form a latent image. The X-rays used are selected to be substantially monochromatic such that the range of wave lengths falls largely or almost totally within the Auger window, as defined, determined by the particular electron shell of the atomic element to be activated to produce the Auger electrons.
Abstract translation: 一种俄歇微光刻工艺，其中基本上单色X射线的光束通过光掩模以从感光层内的选定的原子元件引起俄歇电子，俄格尔电子作用在该层中的材料上以引起其物理化学变化并形成 潜像 使用的X射线被选择为基本上单色，使得波长的范围大大地或几乎完全落在俄歇窗内，如通过待激活的原子元件的特定电子壳确定以产生俄歇电子所定义的。
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公开(公告)号：US4290781A
公开(公告)日：1981-09-22
申请号：US16905
申请日：1979-03-02
Applicant: Chia-Gee Wang
Inventor： Chia-Gee Wang
Abstract: Turbo-separative methods and apparatus for separation of mixtures of gaseous materials having different molecular weights, particularly gaseous isotope mixtures such as mixtures of UF.sub.6, in which differential sedimentation velocities of the components to be separated are established in a laminar boundary layer of the gas adjacent a hydraulically smooth, porous blade surface, and in which a predetermined amount of the boundary layer flow is conducted through the porous surface to stabilize the boundary layer and to provide a higher density gas fraction. The velocity of the gas conducted through the porous blade surface should not exceed the sedimentation velocity of the gas species to be separated.
Abstract translation: 用于分离具有不同分子量的气态材料的混合物的涡轮分离方法和装置，特别是气态同位素混合物，例如UF6的混合物，其中待分离的组分的不同沉降速度建立在相邻气体的层流边界层中 液压平滑多孔叶片表面，并且其中预定量的边界层流通过多孔表面传导以稳定边界层并提供更高密度的气体部分。 通过多孔叶片表面传播的气体的速度不应超过要分离的气体种类的沉降速度。
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