专利检索 ap:("Craig Rosen" OR "George Komatsoulis" OR "Kevin Baker" OR "Michele Fiscella" OR "Paul Moore" OR "Ping Wei" OR "D. Duan" OR "Yanggu Shi" OR "Ram Gupta") AND inv:"Ping Wei" 第 3 页

21.

发明授权
Screening systems and methods for identifying modulators of xenobiotic metabolism 有权
标题翻译：用于鉴定异种生物代谢调节剂的筛选系统和方法

公开(公告)号：US07186879B2

公开(公告)日：2007-03-06

申请号：US10268822

申请日：2002-10-10

申请人： David D. Moore , Ping Wei , Steven S. Chua

发明人： David D. Moore , Ping Wei , Steven S. Chua

IPC分类号： A01K67/00

CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0362 , A61K49/0006 , C07K14/72

摘要： The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify CAR ligands, including compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.

摘要翻译： 本发明提供具有降低的CAR受体活性的小鼠和表达人CAR受体的小鼠。这些小鼠可用于鉴定CAR配体的筛选方法，包括调节CAR受体活性的化合物，可能具有CAR-介导的毒性的化合物，以及具有较低潜在毒性的这些化合物的类似物。

22.

发明申请
SCREENING SYSTEMS AND METHODS FOR IDENTIFYING MODULATORS OF XENOBIOTICMETABOLISM 审中-公开
标题翻译：筛选系统和识别XIBOBOTICMETABOLISM调节剂的方法

公开(公告)号：US20060288436A1

公开(公告)日：2006-12-21

申请号：US11464479

申请日：2006-08-14

申请人： David Moore , Ping Wei , Steven Chua

发明人： David Moore , Ping Wei , Steven Chua

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/70567 , C12N15/8509 , C12N2830/008

摘要： The present invention provides mice having reduced CAR receptor activity and mice expressing a human CAR receptor. These mice are useful in screening methods to identify compounds that modulate CAR receptor activity, compounds likely to have CAR-mediated toxicity, and analogs of these compounds with less potential toxicity.

摘要翻译： 本发明提供具有降低的CAR受体活性的小鼠和表达人CAR受体的小鼠。这些小鼠在筛选方法中可用于鉴定调节CAR受体活性的化合物，可能具有CAR介导的毒性的化合物以及具有较低潜在毒性的这些化合物的类似物。