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21.发明申请公开(公告)号：US20080145934A1
公开(公告)日：2008-06-19
申请号：US10951357
申请日：2004-09-28
IPC分类号： C12N5/06
CPC分类号： C12N5/06 , A61L27/227 , A61L27/52 , A61L27/56 , C12N2533/40 , C12N2533/50
摘要： The present invention is directed to tissue-engineering scaffolds containing both a microporous scaffold made from a biocompatible material suitable for use in tissue-engineering scaffolds and a nanofiberous, nanoporous hydrogel formed from a self-assembling peptide, where at least a portion of the hydrogel is disposed within the pores of the microporous scaffold, thus providing tissue-engineering scaffolds having average pore diameters in the nanometer range and that provide both mechanical properties suitable for implantation into a body of a mammal and excellent tissue response once implanted in the body.
摘要翻译： 本发明涉及包含由适合用于组织工程支架的生物相容性材料制成的微孔支架和由自组装肽形成的纳米纤维，纳米多孔水凝胶的组织工程支架，其中至少一部分水凝胶 设置在微孔支架的孔内，从而提供具有纳米范围内的平均孔径的组织工程支架，并且提供适合于植入哺乳动物身体的机械性能并且一旦植入体内就具有优异的组织反应。
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22.发明授权Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation 有权人类脐带组织细胞用于在组织相容性错配移植中抑制不良免疫应答公开(公告)号：US09175261B2
公开(公告)日：2015-11-03
申请号：US11611602
申请日：2006-12-15
CPC分类号： C12N5/0605 , A61K35/51 , A61K2035/122
摘要： Cell-based compositions and methods of their use to inhibit an adverse immune response such as graft versus host disease or rejection of transplanted tissue in a transplant recipient that is histocompatibility mismatched to the transplant donor are disclosed. The compositions and methods utilize postpartum-derived cells, such as cells derived from the placenta or umbilicus.
摘要翻译： 公开了其基于细胞的组合物和它们用于抑制移植物抗宿主病或移植受体中的移植组织排斥反应的免疫应答的方法，所述组织相容性与移植供体不匹配。 组合物和方法利用产后来源的细胞，例如衍生自胎盘或脐带的细胞。
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公开(公告)号：US08574897B2
公开(公告)日：2013-11-05
申请号：US13492175
申请日：2012-06-08
IPC分类号： C12N1/06
CPC分类号： A61L2/0011 , A61L2/0035 , A61L27/38
摘要： Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.
摘要翻译： 提供了用于对包含生物活性剂的材料进行灭菌的方法，包括以约5kGy至约25kGy的剂量用电离辐射照射所述材料，同时将所述材料保持在包含至少95体积％惰性气体的气氛中， 温度约4℃或更低。 还提供了包含生物活性剂的灭菌材料，其中所述材料表现出与非灭菌对照基本上相同数量的生物活性。
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公开(公告)号：US07901461B2
公开(公告)日：2011-03-08
申请号：US10729046
申请日：2003-12-05
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/38 , A61L2430/06
摘要： Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
摘要翻译： 提供生物相容性组织植入物用于修复组织损伤或缺损。 组织植入物包括用作可进行组织再生和/或修复的活细胞来源的生物组织切片。 生物组织切片可以从健康组织收获，以具有适合于在损伤或缺损部位植入的几何形状。 将收获的组织切片的尺寸设定为允许包含在组织切片内的活细胞移出并增殖并与损伤或缺损部位周围的组织整合。 还提供了使用组织植入物修复组织损伤或缺陷的方法。
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公开(公告)号：US20070292401A1
公开(公告)日：2007-12-20
申请号：US11471215
申请日：2006-06-20
CPC分类号： A61K38/39 , A61K35/28 , A61K35/50 , A61K35/51 , C12N2509/00 , A61K2300/00
摘要： Stem cells products having the potential to support cells of a soft tissue lineage, and methods of preparation and use of those stem cell products are disclosed. The invention also relates to methods for the use of such stem cells products in the regeneration and repair of soft tissue, and in cell-based therapies for of soft tissue conditions.
摘要翻译： 公开了具有支持软组织谱系细胞的潜力的干细胞产品，以及这些干细胞产品的制备和使用方法。 本发明还涉及在软组织的再生和修复中以及用于软组织条件的基于细胞的疗法中使用这种干细胞产物的方法。
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公开(公告)号：US08741638B2
公开(公告)日：2014-06-03
申请号：US11612872
申请日：2006-12-19
申请人： Alexander M. Harmon
发明人： Alexander M. Harmon
CPC分类号： C12N5/0605
摘要： Methods for the maximizing parameter of the in vitro growth and expansion of mammalian cells, specifically postpartum-derived cells in containers such as roller bottles is described. Methods of optimizing growth rate and cell yield in such culture systems are provided. The methods are particularly adapted for human postpartum-derived cells, such as umbilicus-derived cells.
摘要翻译： 描述了最大化哺乳动物细胞的体外生长和扩增参数的方法，特别是产后来源的细胞在容器如滚瓶中的方法。 提供了在这种培养系统中优化生长速率和细胞产量的方法。 该方法特别适用于人产后衍生的细胞，例如脐带来源的细胞。
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公开(公告)号：US08641775B2
公开(公告)日：2014-02-04
申请号：US13018900
申请日：2011-02-01
IPC分类号： A61F2/02
CPC分类号： A61L27/3683 , A61L27/38 , A61L2430/06
摘要： Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
摘要翻译： 提供生物相容性组织植入物用于修复组织损伤或缺损。 组织植入物包括用作可进行组织再生和/或修复的活细胞来源的生物组织切片。 生物组织切片可以从健康组织收获，以具有适合于在损伤或缺损部位植入的几何形状。 将收获的组织切片的尺寸设定为允许包含在组织切片内的活细胞移出并增殖并与损伤或缺损部位周围的组织整合。 还提供了使用组织植入物修复组织损伤或缺陷的方法。
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公开(公告)号：US20120039983A1
公开(公告)日：2012-02-16
申请号：US12854856
申请日：2010-08-11
IPC分类号： A61K9/127 , A61P35/00 , A61K31/337
CPC分类号： A61K9/1271 , A61K31/337
摘要： The invention provides amphiphilic macromolecule (AM)-lipid complexes, methods of making the complexes, and methods of using the complexes.
摘要翻译： 本发明提供了两亲性高分子（AM） - 脂质复合物，制备复合物的方法和使用该配合物的方法。
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29.发明申请公开(公告)号：US20090166178A1
公开(公告)日：2009-07-02
申请号：US12337425
申请日：2008-12-17
IPC分类号： B01J19/08
CPC分类号： A61L2/0011 , A61L2/0035 , A61L27/38
摘要： Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.
摘要翻译： 提供了用于对包含生物活性剂的材料进行灭菌的方法，包括以约5kGy至约25kGy的剂量用电离辐射照射所述材料，同时将所述材料保持在包含至少95体积％惰性气体的气氛中， 温度约4℃或更低。 还提供了包含生物活性剂的灭菌材料，其中所述材料表现出与非灭菌对照基本上相同数量的生物活性。
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公开(公告)号：US10179900B2
公开(公告)日：2019-01-15
申请号：US12339872
申请日：2008-12-19
申请人： Alexander M. Harmon , Abel Ang
发明人： Alexander M. Harmon , Abel Ang
IPC分类号： C12N5/073 , C12N5/0775
摘要： A stable and scalable process is provided to manufacture reduced serum umbilical cord tissue-derived (UTC)-conditioned media. The method includes the culture of a UTC under reduced serum conditions. Subsequently, the UTC is washed and grown in serum-free basal media. After approximately 24 hours, the conditioned media is collected, filtered and concentrated by use of an approximately 5 kDa or similar cut-off membrane.
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