公开(公告)号：US5540665A

公开(公告)日：1996-07-30

申请号：US189473

申请日：1994-01-31

申请人： Stanley A. Mercado ,  Mark M. McPhee ,  Avtar S. Nat ,  Su I. Yum ,  Scott A. Bura

发明人： Stanley A. Mercado ,  Mark M. McPhee ,  Avtar S. Nat ,  Su I. Yum ,  Scott A. Bura

IPC分类号： A61M5/145 ,  C06D5/00 ,  C06D5/10 ,  A61M1/00

CPC分类号： C06D5/10 ,  A61M5/14526 ,  C06D5/00

摘要： The present invention provides a gas generating engine for driving a beneficial agent dispensing device. The engine comprising (a) a solid composition comprising an acidic compound or a basic compound, or a combination thereof, and (b) a means for maintaining substantially constant the surface area of the solid composition exposed to a reservoir fluid comprising water, or water and an acidic compound, or water and a basic compound, wherein in operation, the solid composition is exposed to the reservoir fluid which dissolves the solid composition and causes it to generate a gas, the gas being a driving fluid to dispense a beneficial agent. The present invention further provides a fluid driven dispensing device for delivering an agent into an environment of use, the device be driven by the gas generating engine.

摘要翻译： 本发明提供一种用于驱动有益剂分配装置的气体发生发动机。 所述发动机包括（a）包含酸性化合物或碱性化合物或其组合的固体组合物，和（b）用于使暴露于包含水或水的储液器的固体组合物的表面积基本上恒定的装置 和酸性化合物，或水和碱性化合物，其中在操作中，固体组合物暴露于溶解固体组合物并使其产生气体的储层流体，气体是用于分配有益剂的驱动流体。 本发明还提供一种用于将试剂输送到使用环境中的流体驱动分配装置，该装置由气体发生引擎驱动。

公开(公告)号：US5508039A

公开(公告)日：1996-04-16

申请号：US211786

申请日：1994-06-13

申请人： F. Eugene Yates ,  Lina T. Taskovich ,  Su I. Yum ,  Nieves M. Crisologo

发明人： F. Eugene Yates ,  Lina T. Taskovich ,  Su I. Yum ,  Nieves M. Crisologo

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/40 ,  A61K47/14 ,  A61F13/00

CPC分类号： A61K9/7084 ,  A61K31/40 ,  A61K47/14 ,  A61K9/0014

摘要： The present invention is directed to the transdermal administration of melatonin together with a suitable permeation enhancer. The invention includes a transdermal drug delivery device (10) comprising a matrix (12) adapted to be placed in melatonin- and permeation enhancer-transmitting relation with the skin site (18). The matrix (12) contains sufficient amounts of a permeation enhancer and of melatonin, in combination, to continuously administer to the skin (18) for a predetermined period of time the melatonin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a therapeutically effective amount of melatonin together with a skin permeation-enhancing amount of a suitable permeation enhancer. The invention further includes methods for time- and rate-patterned transdermal delivery of melatonin to simulate the natural circadian rhythmic profile of melatonin in mammals.

摘要翻译： PCT No.PCT / US92 / 08919 Sec。 371日期1994年6月13日 102（e）日期1994年6月13日PCT提交于1992年10月16日PCT出版社 出版物WO93 / 07870 日期：1993年04月29日。本发明涉及褪黑激素与合适的渗透促进剂的透皮给药。 本发明包括透皮药物递送装置（10），其包括适于与皮肤部位（18）放置在与褪黑激素和渗透增强剂 - 传递关系中的基质（12）。 基质（12）含有足够量的渗透促进剂和褪黑激素组合，以连续给予皮肤（18）一段预定的时间，以提供有效的治疗结果。 本发明还涉及一种用于透皮施用治疗有效量的褪黑激素以及皮肤渗透增强量的合适的渗透增强剂的方法。 本发明还包括用于对褪黑激素进行时间和速率图案化的透皮递送以模拟哺乳动物中褪黑激素的天然昼夜节律谱的方法。

公开(公告)号：US5045059A

公开(公告)日：1991-09-03

申请号：US568457

申请日：1990-08-15

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。 在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。 透皮型药物输送装置粘附在窗户的外表面上。 药物由输送装置通过窗口输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。 多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

公开(公告)号：US4929233A

公开(公告)日：1990-05-29

申请号：US236974

申请日：1988-08-26

申请人： Nathan Roth ,  Su I. Yum

发明人： Nathan Roth ,  Su I. Yum

IPC分类号： A61K9/00 ,  A61M5/148

CPC分类号： A61K9/0004 ,  A61M5/1483

摘要： An improved imbibing agent dispenser having a snap-on closure which is highly reliable, is simple to assemble on one end of the agent dispenser, and can be made at minimum expense without requiring heat or an adhesive to bond the closure to the dispenser. The closure is held in place on the dispenser by a locking feature formed by a shoulder on the end of the dispenser and a ledge on an outer, annular wall of the closure, the ledge being removably hooked beneath and biased toward the shoulder to releasably lock the closure to the dispenser. An important aspect of this closure is that the design provides for the complete containment of a solute component within the dispenser.

摘要翻译： 具有高可靠性的卡扣式闭合器的改进的吸液剂分配器易于组装在药剂分配器的一端，并且可以以最小的成本制成，而不需要热或粘合剂将封闭物结合到分配器。 封闭件通过由分配器的端部上的肩部形成的锁定特征保持在分配器上的位置以及在封闭件的外部环形壁上的凸缘，该凸缘可拆卸地钩在下面并朝向肩部偏压以可释放地锁定 关闭到分配器。 该封闭件的一个重要方面是设计提供了在分配器内完全容纳溶质成分。

公开(公告)号：US5250028A

公开(公告)日：1993-10-05

申请号：US741477

申请日：1991-08-09

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M5/14 ,  A61M37/00

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion using permeation enhancers and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过使用渗透促进剂的壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

公开(公告)号：US5234424A

公开(公告)日：1993-08-10

申请号：US691040

申请日：1991-06-25

申请人： Su I. Yum ,  Felix A. Landrau ,  James Z. Huang

发明人： Su I. Yum ,  Felix A. Landrau ,  James Z. Huang

IPC分类号： A61K9/00 ,  A61K9/22

CPC分类号： A61K9/0004

摘要： An improved osmotic engine is disclosed. The osmotic engine is adapted to be used with an osmotically driven syringe which can be used to deliver a beneficial agent, such as a drug, at a pre-determined rate over an extended period of time. The osmotic engine has an exterior wall defining a compartment which contains an osmotic solute. The wall comprises a thin permeable and/or microporous material which is permeable to an external fluid such as water but is impermeable to the solute. The wall also has a delivery orifice drilled therethrough. A rigid non-dissolving ring-shaped wall support is provided for maintaining the shape of the engine during use. The wall support also provides an open fluid flow path extending from the semipermeable wall portion toward the delivery orifice. The open fluid flow path minimizes the time required for the engine to begin pumping.

摘要翻译： PCT No.PCT / US89 / 05669 Sec。 371日期1991年6月25日 102（e）日期1991年6月25日PCT 1989年12月18日提交。公开了改进的渗透引擎。 渗透引擎适于与渗透驱动的注射器一起使用，所述注射器可以在延长的时间段内以预定的速率用于递送诸如药物的有益药剂。 渗透引擎具有限定包含渗透性溶质的隔室的外墙。 该壁包括薄的可渗透和/或微孔材料，其可渗透外部流体例如水，但对溶质是不可渗透的。 墙壁上还有一个穿过其中的输送孔。 提供了一种刚性不溶解环形壁支撑件，用于在使用过程中保持发动机的形状。 壁支撑件还提供从半透壁部分朝向输送孔延伸的开放流体流动路径。 开放的流体流路使发动机开始泵送所需的时间最小化。

公开(公告)号：US4985016A

公开(公告)日：1991-01-15

申请号：US311905

申请日：1989-02-15

申请人： Felix Theeuwes ,  Su I. Yum

发明人： Felix Theeuwes ,  Su I. Yum

IPC分类号： A61M39/00 ,  A61M5/14

CPC分类号： A61M5/1407

摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.

摘要翻译： 提供了用于静脉内给药组的药物制剂室。 静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。 药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。 室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。 透皮型药物输送装置粘附在半透膜/微孔壁部分上。 药物由输送装置通过壁部分输送到流动的IV流体中。 该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。 从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。 多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

公开(公告)号：US5160320A

公开(公告)日：1992-11-03

申请号：US741413

申请日：1991-08-12

申请人： Su I. Yum ,  Felix Theeuwes

发明人： Su I. Yum ,  Felix Theeuwes

IPC分类号： A61M5/14

CPC分类号： A61M5/1407

摘要： An agent formulator (30, 60) for an intravenous administration set (14) is provided. The intravenous administration set (14) includes a container (12) of an IV fluid (13), a drip chamber (22), an agent formulator (30, 60) and an adapter-needle assembly (28). The agent formulator (30, 60) has a fluid inlet (23) and a fluid outlet (25) for maintaining a flow of IV fluid (13 ) therethrough. A portion (36) of the formulator wall (32) is comprised of a window material which allows the agent to diffuse therethrough but which prevents convective loss of the IV fluid (13). A flow distributor (38, 68) is provided within the chamber for distributing the flow of IV fluid (13) along the interior surface of the window (36). A transdermal-type drug delivery device (40) is adhered to the exterior surface of the window (36). Drug is delivered by the delivery device (40) through the window (36) and into the flowing IV fluid (13). The device (40) delivers drug into the IV fluid (13) at a rate that is independent of the flow rate of IV fluid (13) through the formulator (30, 60). The rate of drug delivery from the device (40) into the IV fluid (13) is controlled by either the window (36) itself or by a membrance layer (46) in the drug delivery device (40). A plurality of drug delivery devices (40) may be adhered to the window (36) to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window (11) may be placed in a IV bag to deliver a drug into the IV fluid therein.

摘要翻译： PCT No.PCT / US90 / 00880 Sec。 371日期1991年8月12日 102（e）日期1991年8月12日PCT提交1990年02月14日PCT公布。 出版物WO90 / 09201 日期为1990年8月23日。提供了一种用于静脉内给药组（14）的药剂配方（30,60）。 静脉内给药装置（14）包括IV流体（13），滴注室（22），药剂配制器（30,60）和适配器 - 针组件（28）的容器（12）。 药剂配制器（30,60）具有流体入口（23）和流体出口（25），用于维持IV流体（13）流过其中。 配方设计师壁（32）的一部分（36）由窗口材料构成，该窗材料允许试剂在其中扩散，但防止IV流体（13）的对流损失。 流体分配器（38,68）设置在腔室内，用于沿着窗口（36）的内表面分配IV流体（13）的流动。 透皮型药物输送装置（40）粘附到窗（36）的外表面。 药物通过输送装置（40）通过窗口（36）输送到流动的IV流体（13）中。 装置（40）以与通过配制器（30,60）的IV流体（13）的流速无关的速率将药物递送到IV流体（13）中。 从装置（40）进入IV流体（13）的药物递送速率由窗口（36）本身或药物递送装置（40）中的膜层（46）控制。 多个药物递送装置（40）可以粘附到窗口（36）以递送多种药物或以更高的剂量率递送单一药物。 类似的窗口（11）可以放置在IV袋中以将药物递送到其中的IV流体中。

公开(公告)号：US5104390A

公开(公告)日：1992-04-14

申请号：US503017

申请日：1990-04-02

申请人： Su I. Yum ,  Felix Theeuwes

发明人： Su I. Yum ,  Felix Theeuwes

IPC分类号： A61F5/441

CPC分类号： A61F5/441

摘要： A patient-care apparatus comprising a container for receiving a biological fluid, and a delivery device on the outside of the container, which device comprises a biocide that is released to the container for preventing the multiplication of and/or eliminating the presence of unwanted pathogens in the container.

摘要翻译： 包括用于接收生物流体的容器和在容器外部的输送装置的患者保养装置，该装置包括释放到容器中的杀生物剂，用于防止不希望的病原体的增殖和/或消除不需要的病原体的存在 在容器中

公开(公告)号：US4816258A

公开(公告)日：1989-03-28

申请号：US19163

申请日：1987-02-26

申请人： Diane E. Nedberge ,  Patricia S. Campbell ,  Robert M. Gale ,  Su I. Yum

发明人： Diane E. Nedberge ,  Patricia S. Campbell ,  Robert M. Gale ,  Su I. Yum

IPC分类号： A61K9/70 ,  A61K31/565

CPC分类号： A61K9/7053 ,  A61K31/565 ,  A61K31/567 ,  A61K9/7076 ,  A61K9/7084 ,  Y10S424/14 ,  Y10S514/841 ,  Y10S514/874

摘要： A transdermal delivery system for the administering of ethinyl estradiol and levonorgestrel, in combination, utilizing a polymer matrix having the drug formulation along with a permeation enhancer dispersed throughout.