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公开(公告)号：US06512010B1
公开(公告)日：2003-01-28
申请号：US08892118
申请日：1997-07-14
申请人： Robert M. Gale , Melinda K. Nelson , Michel J. N. Cormier , Suneel K. Gupta , Patricia S. Campbell
发明人： Robert M. Gale , Melinda K. Nelson , Michel J. N. Cormier , Suneel K. Gupta , Patricia S. Campbell
IPC分类号： A61K3135
CPC分类号： A61K9/7084 , A61K31/135 , A61K31/138 , A61K31/57 , A61K2300/00
摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.
摘要翻译： 用于通过穿过身体表面或膜透过体外表面或膜施用氟西汀的物质的组成，所述组合物包含单独或与渗透促进剂或混合物组合的待施用氟西汀。 优选的实施方案涉及在减少的皮肤刺激水平下透皮给药氟西汀，其中氟西汀，优选以醋酸氟西汀提供，与皮质类固醇如氢化可的松共同施用。 还公开了含有氟西汀或氟西汀和增强剂组合物的药物递送装置和用于透皮给药氟西汀和氟西汀/增强剂组合物的方法。
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公开(公告)号：US5693010A
公开(公告)日：1997-12-02
申请号：US608582
申请日：1996-02-28
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/325 , A61N1/0436 , A61N1/0444
摘要： An electrotransport drug delivery device which delivers an anti-inflammatory agent in order to reduce skin irritation associated with electrotransport delivery of the drug is provided. The anti-inflammatory agent is selected from hydrocortisone, esters of hydrocortisone and salts thereof.
摘要翻译： 提供了一种电输送药物递送装置，其递送抗炎剂以减少与药物的电输送递送相关的皮肤刺激。 抗炎剂选自氢化可的松，氢化可的松的酯及其盐。
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公开(公告)号：US4867982A
公开(公告)日：1989-09-19
申请号：US148417
申请日：1988-01-26
CPC分类号： A61K9/7053 , A61K9/0034 , A61K9/0041 , A61K9/7069 , Y10S424/14
摘要： A medical device for the transdermal delivery of an active agent through sensitive intact skin is provided. The device comprises a matrix containing the drug having reinforcing means, preferably in the form of a fabric, embedded in the upper surface of the matrix. The matrix is formed of an agent permeable material which is tacky but does not adhesively bond to the skin. The device is sufficiently flexible and deformable that the combination of tackiness, flexibility, and deformation permits the device to be maintained in agent transmitting relationship upon skin at such sensitive areas as the scrotum, labia, breast, or penis, for example. In certain embodiments, the skin distal surface is provided with a layer of an agent impermeable material to reduce transfer of the agent from the patient to others.
摘要翻译： 提供了通过敏感的完整皮肤透皮递送活性剂的医疗装置。 该装置包括含有药物的基质，其具有嵌入基质的上表面中的优选为织物形式的增强装置。 该基质由粘合剂粘合到皮肤上的可渗透材料形成。 该装置具有足够的柔性和可变形性，使得粘合性，柔韧性和变形性的组合允许例如在阴囊，阴唇，乳房或阴茎等敏感区域将装置保持在皮肤上的药剂传播关系中。 在某些实施方案中，皮肤远端表面设置有不透液剂的层，以减少药剂从患者转移到其他物质。
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公开(公告)号：US4725439A
公开(公告)日：1988-02-16
申请号：US818561
申请日：1986-01-13
CPC分类号： A61K9/7053 , A61K9/0034 , A61K9/0041 , A61K9/7069 , Y10S424/14
摘要： A medical device for the transdermal delivery of an active agent through sensitive intact skin is provided. The device comprises a matrix containing the drug having reinforcing means, preferably in the form of a fabric, embedded in the upper surface of the matrix. The matrix is formed of an agent permeable material which is tacky but does not adhesively bond to the skin. The device is sufficiently flexible and deformable that the combination of tackiness, flexibility, and deformation permits the device to be maintained in agent transmitting relationship upon skin at such sensitive areas as the scrotum, labia, breast, or penis, for example. In certain embodiments, the skin distal surface is provided with a layer of an agent impermeable material to reduce transfer of the agent from the patient to others.
摘要翻译： 提供了通过敏感的完整皮肤透皮递送活性剂的医疗装置。 该装置包括含有药物的基质，其具有嵌入基质的上表面中的优选为织物形式的增强装置。 该基质由粘合剂粘合到皮肤上的可渗透材料形成。 该装置具有足够的柔性和可变形性，使得粘合性，柔韧性和变形性的组合允许例如在阴囊，阴唇，乳房或阴茎等敏感区域将装置保持在皮肤上的药剂传播关系中。 在某些实施方案中，皮肤远端表面设置有不透液剂的层，以减少药剂从患者转移到其他物质。
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