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21.发明授权Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies 有权蛋白酪氨酸激酶7（PTK7）的人单克隆抗体和使用抗PTK7抗体的方法公开(公告)号：US08222375B2
公开(公告)日：2012-07-17
申请号：US12095986
申请日：2006-12-08
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译： 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。
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公开(公告)号：US08680247B2
公开(公告)日：2014-03-25
申请号：US12668965
申请日：2008-07-17
申请人： Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
发明人： Jonathan Alexander Terrett , Li-Sheng Lu , Haichun Huang , Dapeng Yao , Chin Pan , Heidi Leblanc , Timothy Sproul , Mark Yamanaka
IPC分类号： C07K16/30 , A61K39/395 , A61K39/44 , C07K16/46
CPC分类号： C07K16/28 , A61K39/00 , C07K16/303 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.
摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。
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23.发明授权Treating lung cancer using human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) 有权用蛋白酪氨酸激酶7（PTK7）的人单克隆抗体治疗肺癌公开(公告)号：US09505845B2
公开(公告)日：2016-11-29
申请号：US13442499
申请日：2012-04-09
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译： 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。
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公开(公告)号：US09102738B2
公开(公告)日：2015-08-11
申请号：US13468624
申请日：2012-05-10
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译： 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。
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25.发明申请HUMAN MONOCLONAL ANTIBODIES TO PROTEIN TYROSINE KINASE 7 (PTK7) AND METHODS FOR USING ANTI-PTK7 ANTIBODIES 有权人类单克隆抗体蛋白酪氨酸激酶7（PTK7）和使用抗PTK7抗体的方法公开(公告)号：US20100034826A1
公开(公告)日：2010-02-11
申请号：US12095986
申请日：2006-12-08
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/77
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.
摘要翻译： 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。
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