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45 条记录 (耗时 0.035 秒)

    Alpha-1-antitrypsin compositions
    22.
    发明申请
    Alpha-1-antitrypsin compositions 有权
    α-1-抗胰蛋白酶组合物

    公开(公告)号：US20120165261A1

    公开(公告)日：2012-06-28

    申请号：US13385642

    申请日：2012-02-28

    申请人： Scott M. Kee ,  Paul I. Cook ,  James R. Smith ,  Robert Kling ,  Scott A. Fowler ,  David Weber

    发明人： Scott M. Kee ,  Paul I. Cook ,  James R. Smith ,  Robert Kling ,  Scott A. Fowler ,  David Weber

    IPC分类号： A61K38/17 ,  A61P11/00

    CPC分类号： A61K38/57 ,  A61K9/19 ,  B01D15/327 ,  B01D15/363 ,  C07K14/8125 ,  G01N30/461

    摘要： A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.

    摘要翻译： 提供了从含有AAT的蛋白质混合物如Cohn馏分IV沉淀物中纯化α-1-抗胰蛋白酶（AAT）的流线型方法。 在本发明的方法中，污染蛋白质通过用不影响AAT的还原剂如二硫醇裂解二硫键而不稳定。 然后将不稳定的蛋白质优先吸附在固体蛋白质吸附材料上，而不加入作为沉淀剂的盐。 固体吸附剂与溶液的分离留下直接适用于色谱纯化的纯化AAT溶液，而不需像现有技术方法那样进行广泛的脱盐。 还描述了一种以商业规模提供高产量的药物级AAT的方法。

    Method And Apparatus For Signal Power Loss Reduction In RF Communication Systems
    24.
    发明申请
    Method And Apparatus For Signal Power Loss Reduction In RF Communication Systems 有权

    公开(公告)号：US20070117523A1

    公开(公告)日：2007-05-24

    申请号：US11624669

    申请日：2007-01-18

    申请人： David Weber ,  Manolis Terrovitis ,  David Su

    发明人： David Weber ,  Manolis Terrovitis ,  David Su

    IPC分类号： H04B1/46 ,  H04B1/10 ,  H04B1/18

    CPC分类号： H04B7/04 ,  Y02D70/444

    摘要： Multiple power amplifiers in an RF front end are coupled to multiple antennas without diversity switching between the PAs and antennas. Diversity switches direct signals to broadcast by a selected antenna to a PA coupled to the selected antenna. Multiple LNAs are similarly coupled to the diverse antennas. Having one PA and LNA set for each antenna removes the need for diversity switching between the PA/LNAs and each antenna improving signal reception. In one embodiment, a single external PA performs broadcast functions and plural on-chip LNAs are used for reception. In another embodiment, phase shifters are coupled to each PA and LNA, which provide beam forming capability for broadcasts, and in phase signal combinations for received signals.

    Method and apparatus for signal power loss reduction in RF communication systems
    25.
    发明授权
    Method and apparatus for signal power loss reduction in RF communication systems 有权
    RF通信系统信号功率损耗降低的方法和装置

    公开(公告)号：US07212788B2

    公开(公告)日：2007-05-01

    申请号：US10217699

    申请日：2002-08-13

    申请人： David Weber ,  Manolis Terrovitis ,  David Su

    发明人： David Weber ,  Manolis Terrovitis ,  David Su

    IPC分类号： H04B1/44

    CPC分类号： H04B7/04 ,  Y02D70/444

    摘要： Multiple power amplifiers in an RF front end are coupled to multiple antennas without diversity switching between the PAs and antennas. Diversity switches direct signals to broadcast by a selected antenna to a PA coupled to the selected antenna. Multiple LNAs are similarly coupled to the diverse antennas. Having one PA and LNA set for each antenna removes the need for diversity switching between the PA/LNAs and each antenna improving signal reception. In one embodiment, a single external PA performs broadcast functions and plural on-chip LNAs are used for reception. In another embodiment, phase shifters are coupled to each PA and LNA, which provide beam forming capability for broadcasts, and in phase signal combinations for received signals.

    摘要翻译： RF前端中的多个功率放大器耦合到多个天线，而无需在PA和天线之间进行分集切换。 分集将直接信号通过所选天线广播到耦合到所选天线的PA。 多个LNA类似地耦合到多个天线。 为每个天线设置一个PA和LNA消除了PA / LNA之间的分集切换和每个天线改善信号接收的需要。 在一个实施例中，单个外部PA执行广播功能，并且多个片上LNA被用于接收。 在另一个实施例中，移相器耦合到每个PA和LNA，其提供用于广播的波束形成能力，以及用于接收信号的相位信号组合。

    Threaded fastener
    27.
    发明授权
    Threaded fastener 失效
    螺纹紧固件

    公开(公告)号：US4820235A

    公开(公告)日：1989-04-11

    申请号：US78875

    申请日：1987-07-28

    申请人： David Weber ,  Stanley Marchewka

    发明人： David Weber ,  Stanley Marchewka

    IPC分类号： F16B39/282

    CPC分类号： F16B39/282 ,  Y10S411/959

    摘要： An improved threaded fastener is provided with a shank, a head connected to the shank, and a thread form on the shank terminating below the head. A plurality of lugs are provided above at least a portion of the thread form and are circumferentially disposed under the fastener head around the shank seriatim from a first lug to a last lug. Each lug defines an exposed engaging margin extending from the fastener shank at an acute angle relative to the longitudinal axis of the fastener. The maximum radial dimension of each lug progressively increases from the first lug to the last lug while a corresponding maximum axial dimension of each lug progressively decreases whereby the acute angle becomes progressively greater.

    摘要翻译： 改进的螺纹紧固件设置有柄，连接到柄的头部，以及在头部终止的柄上的螺纹形式。 多个凸耳设置在螺纹形式的至少一部分上方，并且周向地设置在紧固件头部周围，该连接头围绕从第一凸耳到最后一个凸耳的连杆。 每个凸耳限定了从紧固件柄以相对于紧固件的纵向轴线成锐角延伸的暴露的接合边缘。 每个凸耳的最大径向尺寸从第一凸耳逐渐增加到最后的凸耳，而每个凸耳的对应的最大轴向尺寸逐渐减小，由此锐角逐渐变大。

    System for generation of useful electrical power from isotopic emissions
    28.
    发明授权
    System for generation of useful electrical power from isotopic emissions 有权

    公开(公告)号：US10109384B2

    公开(公告)日：2018-10-23

    申请号：US13961125

    申请日：2013-08-07

    申请人： David Weber

    发明人： David Weber

    IPC分类号： H02N11/00 ,  G21H1/00 ,  G21H1/04 ,  H01J23/05

    摘要： Particles emitted by radio-isotopic by-products of nuclear fission are used as a power source at the cathode of a magnetron system. Particles include high energy electrons having a large associated EMF. In the system a radial electrical vector E, between the cathode and anode, interacts with an axial magnetic vector B vector to produce an E×B force that rotates the particles about the system axis. These emissions are within a set range of velocities. The angular velocity and geometry of a rotating field, known as a space charge wheel (SCW), may be modulated by an external RF inputs to cavities of an anode block and the use of concentric biasing grids between the cathode and anode block. The SCW induces LC values into cavities of the anode, exciting them and producing electrons resonance which may be used to generate power.

    Method And Apparatus For Signal Power Loss Reduction In RF Communication Systems
    29.
    发明申请
    Method And Apparatus For Signal Power Loss Reduction In RF Communication Systems 有权
    RF通信系统中信号功率降低的方法和装置

    公开(公告)号：US20070072561A1

    公开(公告)日：2007-03-29

    申请号：US11559382

    申请日：2006-11-13

    申请人： David Weber ,  Manolis Terrovitis ,  David Su

    发明人： David Weber ,  Manolis Terrovitis ,  David Su

    IPC分类号： H04B1/44 ,  H04B1/02 ,  H04M1/00

    CPC分类号： H04B7/04 ,  Y02D70/444

    摘要： Multiple power amplifiers in an RF front end are coupled to multiple antennas without diversity switching between the PAs and antennas. Diversity switches direct signals to broadcast by a selected antenna to a PA coupled to the selected antenna. Multiple LNAs are similarly coupled to the diverse antennas. Having one PA and LNA set for each antenna removes the need for diversity switching between the PA/LNAs and each antenna improving signal reception. In one embodiment, a single external PA performs broadcast functions and plural on-chip LNAs are used for reception. In another embodiment, phase shifters are coupled to each PA and LNA, which provide beam forming capability for broadcasts, and in phase signal combinations for received signals.

    摘要翻译： RF前端中的多个功率放大器耦合到多个天线，而无需在PA和天线之间进行分集切换。 分集将直接信号通过所选天线广播到耦合到所选天线的PA。 多个LNA类似地耦合到多个天线。 为每个天线设置一个PA和LNA消除了PA / LNA之间的分集切换和每个天线改善信号接收的需要。 在一个实施例中，单个外部PA执行广播功能，并且多个片上LNA被用于接收。 在另一个实施例中，移相器耦合到每个PA和LNA，其提供用于广播的波束形成能力，以及用于接收信号的相位信号组合。