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公开(公告)号：US07872033B2
公开(公告)日：2011-01-18
申请号：US12100731
申请日：2008-04-10
申请人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Teodozyj Kolasa , Tongmei Li , Derek W. Nelson , Meena V. Patel , Sridhar Peddi , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： C07D417/12 , C07D417/06 , C07D275/03 , C07D275/04 , A61K31/5377 , A61K31/4725 , A61K31/4436 , A61K31/4178 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61K31/415
CPC分类号： A61K31/425 , A61K31/427 , A61K31/429 , A61K31/4436 , A61K31/4725 , A61K31/5377 , C07D275/02 , C07D275/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , Y02P20/582
摘要： The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本申请涉及含有异噻唑基的式（I）化合物，其中R 1，R 2，R 3，R 4和L如说明书中所定义，包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US08173687B2
公开(公告)日：2012-05-08
申请号：US12539120
申请日：2009-08-11
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/433 , C07D285/12
CPC分类号： C07D261/14 , C07D285/135 , C07D407/06 , C07D417/06
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中Y，X1，X2，X3，R1和R2如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20100041720A1
公开(公告)日：2010-02-18
申请号：US12539120
申请日：2009-08-11
申请人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Jennifer M. Frost , Teodozyj Kolasa , Steven P. Latshaw , Bo Liu , Meena V. Patel , Arturo Perez-Medrano , Xueqing Wang
IPC分类号： A61K31/41 , C07D285/135 , C07D231/10 , A61K31/415 , C07D263/30 , A61K31/421
CPC分类号： C07D261/14 , C07D285/135 , C07D407/06 , C07D417/06
摘要： Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本文公开了式（I）的大麻素受体配体，其中Y，X1，X2，X3，R1和R2如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20060009461A1
公开(公告)日：2006-01-12
申请号：US11223857
申请日：2005-09-09
申请人： Pramila Bhatia , Jerome Daanen , Ahmed Hakeem , Teodozyj Kolasa , Mark Matulenko , Kathleen Mortell , Meena Patel , Andrew Stewart , Xueqing Wang , Zhiren Xia , Henry Zhang
发明人： Pramila Bhatia , Jerome Daanen , Ahmed Hakeem , Teodozyj Kolasa , Mark Matulenko , Kathleen Mortell , Meena Patel , Andrew Stewart , Xueqing Wang , Zhiren Xia , Henry Zhang
IPC分类号： A61K31/506 , A61K31/501 , A61K31/496
CPC分类号： A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/427 , A61K31/4418 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/506
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
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25.发明申请公开(公告)号：US20100093814A1
公开(公告)日：2010-04-15
申请号：US12274105
申请日：2008-11-19
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , C07D277/28 , A61P25/00
CPC分类号： C07D277/46 , C07D277/28 , C07D277/48 , C07D277/60 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/04 , C07D513/08
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specfication, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a, Rx, and n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在具体实施方案中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a，R x和n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号：US09006275B2
公开(公告)日：2015-04-14
申请号：US12970480
申请日：2010-12-16
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/429 , C07D513/04 , C07D277/46 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US08546583B2
公开(公告)日：2013-10-01
申请号：US11755434
申请日：2007-05-30
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , A61K31/427 , C07D417/06 , C07D417/14 , C07D277/44
CPC分类号： C07D277/82 , C07D277/46 , C07D277/48 , C07D277/60 , C07D417/06 , C07D417/12 , C07D477/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药物盐，前体药物，前体药物或其组合的盐，其中R1，R2，R3，R4和L1在说明书中定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。 本发明还涉及式（II）化合物或其药物盐，前药，前体药物或其组合的盐，其中R 1a，R 2a和（R x）n如说明书中所定义，包含这些化合物的组合物和方法 使用这些化合物和组合物治疗病症和病症。
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公开(公告)号：US07875639B2
公开(公告)日：2011-01-25
申请号：US11755884
申请日：2007-05-31
申请人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
发明人： Alan S. Florjancic , Michael J. Dart , Keith B. Ryther , Arturo Perez-Medrano , William A. Carroll , Meena V. Patel , Karin Rosemarie Tietje , Tongmei Li , Teodozyj Kolasa , Megan E. Gallagher , Sridhar Peddi , Jennifer M. Frost , Derek W. Nelson
IPC分类号： A61K31/426 , A61K31/427 , A61K31/428 , A61K31/429 , C07D498/04 , C07D493/04 , C07D417/06 , C07D277/46 , C07D277/60 , C07D277/82
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前药，前体药物或其组合的盐，其中R1，R2，R3，R4和L2在说明书中定义，包含这些化合物的组合物， 以及使用这些化合物和组合物治疗病症和病症的方法。
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公开(公告)号：US08865753B2
公开(公告)日：2014-10-21
申请号：US12970435
申请日：2010-12-16
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： A61K31/426 , C07D277/08 , C07D417/12 , C07D513/04 , C07D277/46 , C07D417/06
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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公开(公告)号：US20110086832A1
公开(公告)日：2011-04-14
申请号：US12970435
申请日：2010-12-16
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez-Medrano , Xueqing Wang , Sridhar Peddi , William A. Carroll , Michael J. Dart
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/429 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P37/00 , A61P9/00 , A61P35/00 , A61P11/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D513/04 , Y02P20/582
摘要： The present application relates to thiazolylidene containing compounds of formula (I) wherein R1, R2, R3, R4, L2 and A are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 本申请涉及含有噻唑类的式（I）化合物，其中R 1，R 2，R 3，R 4，L 2和A如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。
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