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    FAN
    4.
    发明申请
    FAN 有权
    风扇

    公开(公告)号：US20130017105A1

    公开(公告)日：2013-01-17

    申请号：US13547749

    申请日：2012-07-12

    申请人： Neil Andrew STEWART ,  Mark James ADKIN ,  David Andrew TIBBETTS

    发明人： Neil Andrew STEWART ,  Mark James ADKIN ,  David Andrew TIBBETTS

    IPC分类号： F04D13/06 ,  F04D29/54

    CPC分类号： F04D25/08 ,  F04D29/441 ,  F04F5/16 ,  F04F5/42 ,  F04F5/54

    摘要： A fan assembly for generating an air flow within a room includes an impeller and a motor for driving the impeller to draw an air flow into the fan assembly, and a casing having a continuous interior passage with a tangential air inlet through which the air flow enters the interior passage and at least one air outlet for emitting at least a portion of the air flow. The casing defines a bore about which the interior passage extends and through which air from outside the fan assembly is drawn by the air emitted from said at least one air outlet.

    摘要翻译： 用于在室内产生空气流的风扇组件包括叶轮和用于驱动叶轮以将空气流吸入风扇组件的马达，以及具有连续内部通道的壳体，该内部通道具有空气流进入的切向空气入口 所述内部通道和至少一个空气出口用于发射所述空气流的至少一部分。 壳体限定一个孔，内部通道围绕该孔延伸，并且来自风扇组件外部的空气通过从所述至少一个空气出口排出的空气被吸入。

    HANGER BEARING COUPLING
    5.
    发明申请
    HANGER BEARING COUPLING 有权
    挂钩联轴器

    公开(公告)号：US20120301064A1

    公开(公告)日：2012-11-29

    申请号：US13479367

    申请日：2012-05-24

    申请人： Andrew Stewart

    发明人： Andrew Stewart

    IPC分类号： F16C35/02

    CPC分类号： F16C35/02 ,  F16C33/76

    摘要： The present device is a hanger bearing coupling which includes a bearing for supporting a shaft, the bearing including an inner race mounted onto the shaft, the bearing mounted between at least two hub assemblies mounted one on either side of the bearing on the shaft; and a hanger including an opening for receiving the bearing there through for operably connecting the bearing to the hanger. Each hub assembly including an inner flex hub mounted to the shaft and an outer flex hub resiliently mounted to the inner flex hub wherein the outer flex hubs are adapted to connect to tubular shafts which may be longitudinally misaligned.

    摘要翻译： 本装置是一种衣架轴承联轴器，其包括用于支撑轴的轴承，所述轴承包括安装在所述轴上的内座圈，所述轴承安装在安装在所述轴上的所述轴承的任一侧上的至少两个轮毂组件之间; 以及衣架，其包括用于接收其中的轴承的开口，用于将轴承可操作地连接到衣架。 每个轮毂组件包括安装到轴的内部柔性轮毂和弹性地安装到内部柔性轮毂的外部柔性轮毂，其中外部柔性轮毂适于连接到可以纵向不对准的管状轴。

    SKATE BOOT WITH IMPROVED FLEXIBILITY
    6.
    发明申请
    SKATE BOOT WITH IMPROVED FLEXIBILITY 有权
    具有改进灵活性的滑雪靴

    公开(公告)号：US20100192412A1

    公开(公告)日：2010-08-05

    申请号：US12522718

    申请日：2008-01-11

    申请人： Andrew Stewart

    发明人： Andrew Stewart

    IPC分类号： A43B7/20 ,  A43D25/12

    CPC分类号： A43B5/16 ,  A43B5/1691 ,  A43B7/18 ,  A43B7/20 ,  A63C1/42

    摘要： A skate boot with a rear element that includes a tendon guard upwardly extending from an outsole of the boot is disclosed. The rear element covers at least a rear portion of an ankle received within the boot. The rear element has a base in connection with a heel portion of the outsole such that the rear element is displaceable relative a remainder of the boot in a forward and rearward direction about the connection. The rear element is an external element of the boot, and has a desired flexibility allowing the rear element to flex in the forward and rearward direction following a given forward and rearward flexion of the ankle.

    摘要翻译： 公开了一种具有后部元件的滑冰靴，其包括从靴子的外底向上延伸的腱护罩。 后部元件覆盖在靴子内部接收的踝部的至少后部。 后部元件具有与鞋外底的后跟部分相连的基部，使得后部元件相对于围绕连接件的向前和向后方向的保护罩的其余部分可移动。 后部元件是护罩的外部元件，并且具有期望的柔性，允许后部元件沿着脚踝的给定的向前和向后弯曲在向前和向后方向上弯曲。

    COMPUTER PROGRAM UPDATES FOR MOBILE COMPUTING DEVICE
    7.
    发明申请
    COMPUTER PROGRAM UPDATES FOR MOBILE COMPUTING DEVICE 审中-公开
    移动计算机设备的计算机程序更新

    公开(公告)号：US20090260004A1

    公开(公告)日：2009-10-15

    申请号：US12101004

    申请日：2008-04-10

    申请人： Mainak Datta ,  Andrew Stewart ,  James (Jianhua) Fan ,  Sateesh Krishna Shiradwade

    发明人： Mainak Datta ,  Andrew Stewart ,  James (Jianhua) Fan ,  Sateesh Krishna Shiradwade

    IPC分类号： G06F9/445

    CPC分类号： H04L67/06 ,  G06F8/65 ,  H04L67/34 ,  H04M1/72525

    摘要： A system and method for updating a computer program on a mobile computing device comprises uploading of packages to a repository, wherein each package comprises update data for a different portion of the computer program, a server identifying portions of the computer program to be updated on a device based on comparing information reported by the device and metadata about packages in the repository and a download server configured to wirelessly download the packages to the mobile computing device. The device may report back installation status to a server.

    摘要翻译： 一种用于在移动计算设备上更新计算机程序的系统和方法包括将包上传到存储库，其中每个包包括用于计算机程序的不同部分的更新数据，识别要更新的计算机程序的部分的服务器 设备，其基于所述设备报告的信息和所述存储库中的包的元数据以及被配置为将所述包无线地下载到所述移动计算设备的下载服务器。 设备可能会将安装状态报告给服务器。

    Human Niemann Pick C1-Like 1 Gene (NPC1L1) Polymorphisms and Methods of Use Thereof
    8.
    发明申请
    Human Niemann Pick C1-Like 1 Gene (NPC1L1) Polymorphisms and Methods of Use Thereof 审中-公开
    人类Niemann Pick C1-Like 1 Gene（NPC1L1）多态性及其使用方法

    公开(公告)号：US20090192135A1

    公开(公告)日：2009-07-30

    申请号：US11887346

    申请日：2006-03-28

    申请人： Jason Samuel Simon ,  Maha Chabhar Karnoub ,  Michael E. Severino ,  David James Devlin ,  Andrew Stewart Plump ,  Eric E. Schadt

    发明人： Jason Samuel Simon ,  Maha Chabhar Karnoub ,  Michael E. Severino ,  David James Devlin ,  Andrew Stewart Plump ,  Eric E. Schadt

    IPC分类号： A61K31/397 ,  C12Q1/60 ,  C12Q1/68 ,  C40B30/04 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention relates to the identification and use of single nucleotide polymorphisms and haplotypes in the Niemann Pick C1-Like 1 (NPC1L1) gene. In particular, methods are provided for correlating NPC1L1 polymorphisms and haplo-types with the responsiveness of a pharmaceutically active compound administered to a human subject. The invention further relates to a method for estimating the responsiveness of a pharmaceutically active compound administered to a human subject which method comprises determining at least one polymorphism in the NPC1L1 gene. The methods are based on determining polymorphisms in the NPC1L1 gene and correlating the responsiveness of a pharmaceutically active compound in the human by reference to one or more polymorphism in NPC1L1. The invention further relates to isolated nucleic acids comprising within their sequence the polymorphisms as defined herein, to nucleic acid primers and oligonucleotide probes capable of hybridizing to such nucleic acids and to a diagnostic kit comprising one or more of such primers and probes for detecting a polymorphism in the NPC1L1 gene.

    摘要翻译： 本发明涉及Niemann Pick C1-Like 1（NPC1L1）基因中单核苷酸多态性和单元型的鉴定和应用。 特别地，提供了将NPC1L1多态性和单体类型与施用于人类受试者的药学活性化合物的反应性相关联的方法。 本发明还涉及一种用于估计施用于人受试者的药学活性化合物的反应性的方法，所述方法包括确定NPC1L1基因中的至少一个多态性。 该方法基于确定NPC1L1基因中的多态性，并通过参照NPC1L1中的一个或多个多态性将药物活性化合物在人体中的反应性相关联。 本发明还涉及在其序列中包含本文所定义的多态性的分离的核酸与能够与此类核酸杂交的核酸引物和寡核苷酸探针以及包含一种或多种用于检测多态性的引物和探针的诊断试剂盒 在NPC1L1基因中。

    SECURE DATA STORAGE AND RETRIEVAL INCORPORATING HUMAN PARTICIPATION
    9.
    发明申请
    SECURE DATA STORAGE AND RETRIEVAL INCORPORATING HUMAN PARTICIPATION 有权
    安全数据存储和检索并入人参与

    公开(公告)号：US20080320554A1

    公开(公告)日：2008-12-25

    申请号：US11690685

    申请日：2007-03-23

    申请人： Arthur H. Baker ,  Brian J. Guarraci ,  Andrew Stewart Tucker ,  Gennady Medvinsky ,  Tanmoy Dutta

    发明人： Arthur H. Baker ,  Brian J. Guarraci ,  Andrew Stewart Tucker ,  Gennady Medvinsky ,  Tanmoy Dutta

    IPC分类号： G06F21/00 ,  H04L9/06

    CPC分类号： G06F21/31 ,  H04L9/32

    摘要： A computer related security mechanism requires that a human participate in an access verification sequence. Upon a request to access secure data, a puzzle is provided to the requester. Proper solution of the puzzle requires human participation. The puzzle is chosen such that its solution is within the capabilities of a human, but beyond the current state of the art for computer systems. The puzzled can be visually and/or audibly rendered to the user. In one configuration, the puzzle is obtained via a library of pluggable puzzle generators. Puzzle generators in the library can be replaced as the state of the art of computing technology improves.

    摘要翻译： 计算机相关的安全机制要求人们参与访问验证序列。 在请求访问安全数据时，向请求者提供了一个难题。 拼图的正确解决需要人类参与。 这个难题被选中，使得它的解决方案在人类的能力范围之内，但超出了现有的计算机系统的现状。 困惑的可以视觉和/或听觉地呈现给用户。 在一个配置中，拼图通过可插拔拼图发生器库获得。 随着计算技术的先进水平的提高，图书馆中的拼图发生器可以被替代。

    Method of peptide synthesis
    10.
    发明申请
    Method of peptide synthesis 失效
    肽合成方法

    公开(公告)号：US20060241282A1

    公开(公告)日：2006-10-26

    申请号：US10566601

    申请日：2004-07-30

    申请人： Andrew Stewart

    发明人： Andrew Stewart

    IPC分类号： C07K14/52 ,  C07K1/02

    CPC分类号： C07K1/042 ,  C07K14/521

    摘要： A method for synthesizing a given peptide or its derivative which contains a proline residue or a proline derivative, at proximity to, or at, the C-terminal end of said peptide is provided. The method comprises a) synthesizing on a first resin a C-terminal portion of said peptide, or its derivative, comprising at least three successive amino acid residues or their derivatives, by successive coupling of selected amino acids, small peptides or their derivatives; b) cleaving the C-terminal portion from said first resin; c) reattaching said C-terminal portion to a second resin which is generally suitable for the synthesis of peptides but is unsuitable for the formation of peptides having a proline residue positioned at the C-terminal end of said peptide; and d) coupling selected amino acids, small peptides or derivatives to the C-terminal portion.

    摘要翻译： 提供了在所述肽的C-末端合成给定肽或其衍生物的方法，所述肽或其衍生物含有脯氨酸残基或脯氨酸衍生物，在所述肽的C末端附近或位置。 该方法包括：a）通过连续偶联选择的氨基酸，小肽或其衍生物，在第一树脂上合成所述肽或其衍生物的C末端部分或其衍生物，其包含至少三个连续的氨基酸残基或其衍生物; b）从所述第一树脂切割C端部分; c）将所述C末端部分重新连接到通常适于合成肽的第二树脂，但不适于形成具有位于所述肽的C末端的脯氨酸残基的肽; 和d）将选择的氨基酸，小肽或衍生物偶联到C末端部分。