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公开(公告)号：US07186542B2
公开(公告)日：2007-03-06
申请号：US10916378
申请日：2004-08-10
CPC分类号： C12N7/00 , A61K35/765 , C12N2720/12232 , C12N2720/12251
摘要： The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.
摘要翻译： 本发明涉及从细胞培养物中提取病毒，特别是呼肠弧病毒的方法。 感染性病毒可以用诸如25℃或37℃的方便温度的洗涤剂从培养物中提取，以产生高病毒效价。 离子和非离子洗涤剂都可用于本发明。
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公开(公告)号：US06528305B2
公开(公告)日：2003-03-04
申请号：US09920012
申请日：2001-08-02
IPC分类号： C12N506
CPC分类号： A61K35/765 , C12N7/00 , C12N2510/02 , C12N2720/12011 , C12N2720/12032 , C12N2720/12051
摘要： A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus.
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23.发明申请ABROGATING PROINFLAMMATORY CYTOKINE PRODUCTION DURING ONCOLYTIC REOVIRUS THERAPY 审中-公开肿瘤性溃疡治疗期间抗肿瘤细胞因子生产的研究公开(公告)号：US20130243732A1
公开(公告)日：2013-09-19
申请号：US13898771
申请日：2013-05-21
IPC分类号： A61K35/76 , A61K31/282 , A61K33/24
CPC分类号： A61K35/765 , A61K31/282 , A61K31/555 , A61K33/24 , C12N2720/12032 , A61K2300/00
摘要： Provided herein are methods for treating a proliferative disorder in a subject comprising administering to the subject one or more reoviruses and one or more agents that modulate expression or activity of pro-inflammatory cytokines. For example, the agents may inhibit expression or activity of pro-inflammatory cytokines.
摘要翻译： 本文提供了治疗受试者中增殖性病症的方法，包括向受试者施用一种或多种呼肠孤病毒和一种或多种调节促炎细胞因子的表达或活性的试剂。 例如，该试剂可抑制促炎细胞因子的表达或活性。
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24.发明申请Sensitization of Chemotherapeutic Agent Resistant Neoplastic Cells With a Virus 审中-公开具有病毒的耐化学药物抗肿瘤细胞的致敏作用公开(公告)号：US20110243890A1
公开(公告)日：2011-10-06
申请号：US13109631
申请日：2011-05-17
CPC分类号： A61K33/24 , A61K35/765 , A61K45/06 , C12N2720/12232 , A61K2300/00
摘要： The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus and chemotherapeutic agents, and a method for preventing a neoplasm from developing drug resistance to chemotherapeutic agents. The virus is preferably a reovirus.
摘要翻译： 本发明涉及通过使用病毒增加肿瘤细胞对化学治疗剂的敏感性的方法，使用病毒和化学治疗剂治疗增殖性病症的方法以及预防肿瘤对化疗药物的耐药性的方法。 病毒优选为呼肠孤病毒。
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公开(公告)号：US20080292594A1
公开(公告)日：2008-11-27
申请号：US12124522
申请日：2008-05-21
CPC分类号： C12N7/00 , A61K35/13 , A61K2035/11 , C07K14/005 , C12N2720/12021 , C12N2720/12022
摘要： Provided herein is a mutant reovirus (e.g., a genetically-engineered ISVP). Compositions including mutant reoviruses and methods of using such mutant reoviruses are also provided.
摘要翻译： 本文提供突变型呼肠孤病毒（例如，遗传工程ISVP）。 还提供了包括突变型呼肠病毒的组合物和使用这种突变型呼肠孤病毒的方法。
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26.发明授权Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 有权用于预防呼肠孤病毒识别用于治疗细胞增殖性疾病的方法公开(公告)号：US07452723B2
公开(公告)日：2008-11-18
申请号：US11255849
申请日：2005-10-21
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells.
摘要翻译： 本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。 该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。 所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。 或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。
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公开(公告)号：US06808916B2
公开(公告)日：2004-10-26
申请号：US10097183
申请日：2002-03-14
IPC分类号： C12N706
CPC分类号： C12N7/00 , A61K35/765 , C12N2720/12232 , C12N2720/12251
摘要： The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.
摘要翻译： 本发明涉及从细胞培养物中提取病毒，特别是呼肠弧病毒的方法。 感染性病毒可以用诸如25℃或37℃的方便温度的洗涤剂从培养物中提取，以产生高病毒效价。 离子和非离子洗涤剂都可用于本发明。
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公开(公告)号：US06596268B1
公开(公告)日：2003-07-22
申请号：US09708663
申请日：2000-11-09
IPC分类号： A61K4800
CPC分类号： A61K35/761 , A61K38/13 , A61K45/06 , C12N2710/10032 , C12N2710/24132 , A61K2300/00
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
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公开(公告)号：US20120156168A1
公开(公告)日：2012-06-21
申请号：US13297384
申请日：2011-11-16
CPC分类号： A61K35/76 , A61K35/13 , C12N2710/10032
摘要： Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
摘要翻译： 公开了通过向具有活化的Ras通路的增殖细胞施用病毒来治疗细胞增殖障碍的方法。 施用病毒使得其最终直接接触具有活化的Ras途径的增殖细胞。 增生性疾病包括但不限于赘生物。 病毒选自修饰的腺病毒，修饰的HSV，修饰的痘苗病毒和修饰的副痘病毒或病毒。 还公开了通过进一步施用免疫抑制剂来治疗细胞增殖性疾病的方法。
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公开(公告)号：US20100247622A1
公开(公告)日：2010-09-30
申请号：US12678851
申请日：2008-10-22
IPC分类号： A61K39/395 , A61K35/76 , A61K9/127 , A61P35/00
CPC分类号： A61K45/06 , A61K31/664 , A61K35/765 , A61K39/12 , A61K39/15 , A61K2039/585 , A61K2300/00 , C12N2720/12032 , C12N2720/12034
摘要： Provided herein are methods for treating or ameliorating a proliferative disorder in a subject. The method contains the steps of administering to the subject one dose of an immunosuppressive agent followed by administering to the subject one to five doses of a reovirus. The immunosuppressive agent is administered to the subject at least about 72 hours prior to administration of the reovirus. Also provided herein are methods for treating or ameliorating a proliferative disorder in a subject including the steps of administering to the subject an oncolytic virus and a B-cell modulating agent. Also provided are kits and pharmaceutical compositions containing an oncolytic virus and at least one B-cell modulating agent.
摘要翻译： 本文提供了治疗或改善受试者中增殖性疾病的方法。 该方法包括以下步骤：向受试者施用一剂量的免疫抑制剂，然后向受试者施用一至五剂呼肠弧病毒。 在施用呼肠孤病毒前至少约72小时向受试者施用免疫抑制剂。 本文还提供了治疗或改善受试者中增殖性疾病的方法，包括给患者施用溶瘤病毒和B细胞调节剂的步骤。 还提供了含有溶瘤病毒和至少一种B细胞调节剂的试剂盒和药物组合物。
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