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    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
    6.
    发明授权
    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 失效
    用于预防呼肠孤病毒识别用于治疗细胞增殖性疾病的方法

    公开(公告)号：US07708987B2

    公开(公告)日：2010-05-04

    申请号：US11809195

    申请日：2007-05-30

    申请人： Matthew C. Coffey ,  Bradley G. Thompson

    发明人： Matthew C. Coffey ,  Bradley G. Thompson

    IPC分类号： A61K48/00 ,  A61K39/15 ,  A61K39/42 ,  C12N7/04

    CPC分类号： A61K35/765 ,  A61K38/13 ,  C07K16/081 ,  C07K16/10 ,  C07K16/4216 ,  C12N9/1205 ,  C12N2720/12232 ,  Y10S435/948 ,  Y10S435/975 ,  A61K2300/00

    摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.

    摘要翻译： 本发明涉及在哺乳动物中治疗细胞增殖性疾病，特别是ras介导的细胞增殖性疾病中预防呼肠孤病毒识别的方法。 哺乳动物可以选自狗，猫，绵羊，山羊，牛，马，猪，小鼠，人和非人灵长类动物。 该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，并且同时或随后在导致增殖细胞的实质性裂解的条件下向增殖细胞施用有效量的一种或多种呼吸道病毒。 特别地，该方法提供了呼肠孤病毒治疗免疫抑制或免疫缺陷型哺乳动物以治疗增殖性疾病。 在哺乳动物中的免疫抑制，免疫抑制或其他诱导免疫缺陷状态使呼肠孤病毒更有效。 所述方法可以包括选择性去除可能干扰病毒的全身递送的免疫组分; 预防宿主免疫系统的呼肠孤病毒识别; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不称职的宿主中除去病毒。 或者，呼肠孤病毒可以在导致增殖细胞的实质性裂解的条件下给予具有减少的免疫应答系统的哺乳动物。 免疫系统可能受到以下一种或多种感染：HIV感染; 作为化疗或放射治疗的副作用; 通过选择性去除B和/或T细胞群体; 通过除去抗体（抗 - 抗病毒抗体或全部抗体）等。

    Method of extracting virus from cell culture
    8.
    发明授权
    Method of extracting virus from cell culture 有权
    从细胞培养中提取病毒的方法

    公开(公告)号：US07186542B2

    公开(公告)日：2007-03-06

    申请号：US10916378

    申请日：2004-08-10

    申请人： Matthew C. Coffey ,  Bradley G. Thompson

    发明人： Matthew C. Coffey ,  Bradley G. Thompson

    IPC分类号： C12N7/00 ,  A61K39/15

    CPC分类号： C12N7/00 ,  A61K35/765 ,  C12N2720/12232 ,  C12N2720/12251

    摘要： The present invention is directed to a method of extracting virus, particularly reovirus, from a culture of cells. Infectious virus can be extracted from the culture with a detergent at a convenient temperature such as 25° C. or 37° C. to produce high virus titers. Both ionic and non-ionic detergents can be used in the present invention.

    摘要翻译： 本发明涉及从细胞培养物中提取病毒，特别是呼肠弧病毒的方法。 感染性病毒可以用诸如25℃或37℃的方便温度的洗涤剂从培养物中提取，以产生高病毒效价。 离子和非离子洗涤剂都可用于本发明。

    VIRUS CLEARANCE OF NEOPLASTIC CELLS FROM MIXED CELLULAR COMPOSITIONS
    10.
    发明申请
    VIRUS CLEARANCE OF NEOPLASTIC CELLS FROM MIXED CELLULAR COMPOSITIONS 有权
    来自混合细胞组成的神经细胞的病毒清除

    公开(公告)号：US20130273012A1

    公开(公告)日：2013-10-17

    申请号：US13903236

    申请日：2013-05-28

    申请人： Donald Morris ,  Bradley G. Thompson ,  Matthew C. Coffey

    发明人： Donald Morris ,  Bradley G. Thompson ,  Matthew C. Coffey

    IPC分类号： C12N5/078

    CPC分类号： C12N5/0634 ,  A61K35/28 ,  A61K35/761 ,  A61K35/768 ,  C12N2720/12032

    摘要： The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different purposes, for example, to purge hematopoietic stem cells prior to transplantation. Also provided are compositions prepared according to this method, and kits comprising a combination of viruses which are useful in this invention.

    摘要翻译： 本发明涉及通过使用选择性感染和杀死肿瘤细胞的病毒，从活体外部的混合细胞组合物中去除肿瘤细胞的方法。 在该方法中可以使用各种病毒以除去不同目的的肿瘤细胞，例如在移植前清除造血干细胞。 还提供了根据该方法制备的组合物，以及包含可用于本发明的病毒组合的试剂盒。