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公开(公告)号：US11672800B2
公开(公告)日：2023-06-13
申请号：US16606833
申请日：2018-04-20
Applicant: Epizyme, Inc.
Inventor： John Emmerson Campbell , Kenneth William Duncan , Maria Alejandra Raimondi , Christine Klaus , Elayne Penebre
IPC: A61K31/505 , A61K31/506 , A61P35/00 , A61K31/203 , A61K31/4375 , A61K31/44 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/706
CPC classification number: A61K31/506 , A61K31/203 , A61K31/4375 , A61K31/44 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/706 , A61P35/00
Abstract: The present disclosure relates to a method of preventing or treating a cancer via administering an EHMT2 inhibitor or a combination comprising an EHMT2 inhibitor compound and one or more additional therapeutic agent disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds or combinations for research or other non-therapeutic purposes.
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公开(公告)号：US11642346B2
公开(公告)日：2023-05-09
申请号：US16499476
申请日：2018-03-30
Applicant: Epizyme, Inc.
Inventor： Christine Klaus , Maria Alejandra Raimondi
IPC: A61K31/5377 , A61K31/282 , A61K31/4184 , A61K31/436 , A61K31/4406 , A61K31/4745 , A61K31/475 , A61K31/506 , A61K31/519 , A61K31/55 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/445 , A61K31/496 , A61K31/4412 , A61K38/15 , A61N5/10 , A61P35/00
CPC classification number: A61K31/5377 , A61K31/282 , A61K31/4184 , A61K31/436 , A61K31/4406 , A61K31/475 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K31/55 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K38/15 , A61N5/10 , A61P35/00
Abstract: The present disclosure relates to methods of a malignant rhabdoid tumor (MRT), a rhabdoid tumor of the kidney (RTK), an atypical teratoid/rhabdoid tumor (AT/RT), an epithelioid malignant peripheral nerve sheath tumor, a myoepithelial carcinoma, and/or a renal medullary carcinoma by using an EZH2 inhibitor in combination with one or more additional treatment modalities.
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Patent Agency Ranking
公开(公告)号：US20170232030A1
公开(公告)日：2017-08-17
申请号：US15503542
申请日：2015-08-12
Applicant: Epizyme, Inc. , Celgene Corporation
Inventor： Christine Klaus , Maria Alejandra Raimondi , Scott Richard Daigle , Roy MacFarlane Pollock , Vivek Chopra
IPC: A61K31/7064 , A61K31/7068 , A61K31/519 , A61K45/06 , A61K31/706
CPC classification number: A61K31/7064 , A61K31/135 , A61K31/136 , A61K31/4045 , A61K31/4745 , A61K31/519 , A61K31/5377 , A61K31/704 , A61K31/706 , A61K31/7068 , A61K31/7076 , A61K45/06 , A61P35/00 , A61K2300/00
Abstract: The disclosure relates to combinations comprising inhibitors of human histone methyltransferase DOT1L and one or more therapeutic agents, particularly anticancer agents, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20170080010A1
公开(公告)日：2017-03-23
申请号：US15248080
申请日：2016-08-26
Applicant: Epizyme, Inc.
Inventor： Christine Klaus , Maria Alejandra Raimondi , Scott R. Daigle , Roy MacFarlane Pollock
IPC: A61K31/7076 , A61K31/706 , A61K31/635 , A61K31/4745 , A61K31/7068 , A61K31/135 , A61K31/704 , A61K31/136
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase DOT1L and one or more therapeutic agents, particularly anticancer agents, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20160332969A1
公开(公告)日：2016-11-17
申请号：US15162453
申请日：2016-05-23
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki
IPC: C07D213/64 , C07D405/12 , C07D491/113 , C07D491/048 , C07D405/14 , C07D409/12 , C07D491/08 , C07D401/12 , C07D401/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20140288041A1
公开(公告)日：2014-09-25
申请号：US14275667
申请日：2014-05-12
Applicant: EPIZYME, INC.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D405/12 , C07D401/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US08765732B2
公开(公告)日：2014-07-01
申请号：US13722807
申请日：2012-12-20
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/00 , A61K31/55 , A61K31/535 , A61K31/445 , A61K31/44 , C07D281/02 , C07D243/08 , C07D419/00 , C07D401/00
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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