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公开(公告)号：US11052093B2
公开(公告)日：2021-07-06
申请号：US16660339
申请日：2019-10-22
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/4412 , A61K31/553 , A61K31/551 , C07D213/64 , C07D409/12 , C07D498/08 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20130123234A1
公开(公告)日：2013-05-16
申请号：US13722807
申请日：2012-12-20
Applicant: EPIZYME, INC. , EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D401/12 , C07D491/08 , C07D417/12 , C07D491/107 , C07D405/14 , C07D409/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US10155002B2
公开(公告)日：2018-12-18
申请号：US15346677
申请日：2016-11-08
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , C07D498/08 , C07D213/64 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US09855275B2
公开(公告)日：2018-01-02
申请号：US15598078
申请日：2017-05-17
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/4412 , A61K31/553 , A61K31/551 , C07D213/64 , C07D409/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14 , C07D498/08 , A61K31/496 , A61K31/4709 , A61K31/4545 , A61K31/4439 , A61K31/4436 , A61K31/4433 , A61K31/443 , C07D401/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20170119780A1
公开(公告)日：2017-05-04
申请号：US15346677
申请日：2016-11-08
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/444 , A61K31/4545 , A61K31/4439 , A61K31/4433 , A61K31/4436 , A61K31/551 , A61K31/553 , A61K31/506 , A61K31/443 , A61K31/4709 , A61K31/4412 , A61K31/496
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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Patent Agency Ranking
公开(公告)号：US12168015B2
公开(公告)日：2024-12-17
申请号：US18606925
申请日：2024-03-15
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20140288041A1
公开(公告)日：2014-09-25
申请号：US14275667
申请日：2014-05-12
Applicant: EPIZYME, INC.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D405/12 , C07D401/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US08765732B2
公开(公告)日：2014-07-01
申请号：US13722807
申请日：2012-12-20
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/00 , A61K31/55 , A61K31/535 , A61K31/445 , A61K31/44 , C07D281/02 , C07D243/08 , C07D419/00 , C07D401/00
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US11642348B2
公开(公告)日：2023-05-09
申请号：US16924962
申请日：2020-07-09
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , John Emmerson Campbell , Masashi Seki , Syuji Shirotori , Wataru Itano , Wanjun Zheng
IPC: C07D405/14 , C07D213/64 , C07D401/12 , C07D405/12 , A61K31/5377 , A61K31/5375 , A61K31/4412 , A61K31/4545
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61K31/5375 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US10420775B2
公开(公告)日：2019-09-24
申请号：US15816907
申请日：2017-11-17
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/4412 , A61K31/553 , A61K31/551 , C07D213/64 , C07D409/12 , C07D498/08 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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