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公开(公告)号：US20170119741A1
公开(公告)日：2017-05-04
申请号：US15181284
申请日：2016-06-13
Applicant: Elixir Medical Corporation
Inventor： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC: A61K31/436 , A61K45/06 , A61K9/00
CPC classification number: A61K31/436 , A61K9/0004 , A61K31/439 , A61K31/4525 , A61K45/06
Abstract: The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.
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公开(公告)号：US20160045342A1
公开(公告)日：2016-02-18
申请号：US14682014
申请日：2015-04-08
Applicant: Elixir Medical Corporation
Inventor： John Yan , Vinayak Bhat
IPC: A61F2/89
CPC classification number: A61F2/89 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2210/0004 , A61F2230/001 , A61F2230/0069 , A61L31/022 , A61L31/06 , A61L31/14 , A61L31/148 , A61L31/16 , A61L31/18 , C08L67/04
Abstract: A biodegradable stent prosthesis formed from a degradable polymeric material, having a plurality of luminal, abluminal, and side surfaces, where at least some of the abluminal surfaces are concave and optionally the side surfaces are convex.
Abstract translation: 由可降解的聚合物材料形成的可生物降解的支架假体，其具有多个管腔，外侧和侧面，其中至少一些所述外侧表面是凹形的，并且可选地所述侧表面是凸形的。
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公开(公告)号：US20150320577A1
公开(公告)日：2015-11-12
申请号：US14804415
申请日：2015-07-21
Applicant: Elixir Medical Corporation
Inventor： Xiaoxia Zheng , John Yan , Vinayak Bhat
IPC: A61F2/82
CPC classification number: A61F2/915 , A61F2/82 , A61F2/90 , A61F2/91 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2230/0013 , A61F2230/0069 , A61F2240/001 , A61F2250/0073 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , B33Y80/00 , C08L67/04
Abstract: The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.
Abstract translation: 本公开提供了可生物降解的可植入装置，例如包括可生物降解聚合物的支架，其中处理聚合物材料以控制结晶度和/或Tg。 支架能够在体腔中的体温从卷曲构型扩展到展开的直径，并且具有足够的强度来支撑体腔。
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公开(公告)号：US20140188243A1
公开(公告)日：2014-07-03
申请号：US14097087
申请日：2013-12-04
Applicant: Elixir Medical Corporation
Inventor： Xiaoxia Zheng , John Yan , Vinayak Bhat
IPC: A61L27/58
CPC classification number: A61L27/58 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2210/0004 , A61F2250/0036 , A61L31/041 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2400/16 , B33Y80/00 , C08L67/04
Abstract: The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.
Abstract translation: 本公开提供了可生物降解的可植入装置，例如包括可生物降解聚合物的支架，其中处理聚合物材料以控制结晶度和/或Tg。 支架能够在体温下从卷曲构型扩展到展开直径，并具有足够的强度来支撑体腔。
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公开(公告)号：US20240260984A1
公开(公告)日：2024-08-08
申请号：US18636086
申请日：2024-04-15
Applicant: Elixir Medical Corporation
Inventor： Motasim Sirhan , Vinayak Bhat , Benjamyn Serna , Samit Mustafa , Brett Cryer , Kim Nguyen , John Yan
IPC: A61B17/221 , A61B17/00 , A61B17/22
CPC classification number: A61B17/221 , A61B2017/00358 , A61B2017/0084 , A61B2017/22079 , A61B2017/2212
Abstract: An aspiration catheter for removing clot from a blood vessel includes a catheter body having a scaffold extending distally from a distal end of the body. An aspiration lumen runs from the distal end to a proximal end of the body, and a central clot-receiving passage in the scaffold is contiguous with the aspiration lumen of the catheter body. A vacuum-resistant membrane covers the scaffold and establishes a clot aspiration path from a distal end of the scaffold to a proximal end of the aspiration lumen, in the catheter body so that applying a vacuum to the proximal end of the aspiration lumen can draw clot into the central clot-receiving passage. The scaffold may have a comical configuration, a cylindrical configuration, or a combination thereof, and at least a distal portion of the scaffold is radially expandable from a delivery configuration to an extraction configuration.
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Patent Agency Ranking
公开(公告)号：US12011184B2
公开(公告)日：2024-06-18
申请号：US17863265
申请日：2022-07-12
Applicant: Elixir Medical Corporation
Inventor： Motasim Sirhan , Benjamyn Serna , Bozena Treadwell , John Yan
CPC classification number: A61B17/22 , A61F2/2418 , A61F2/2436 , A61B2017/00783 , A61B2017/22001 , A61B2017/22051 , A61B2017/22098 , A61F2250/006
Abstract: Balloon catheters, sleeves, cages, and endoluminal prostheses are provided with stress-applying and spacing features coupled to expandable surfaces thereof. The stress-applying features may have blunt and/or rounded contact regions which contact tissue or calcified regions in the vasculature. The contact regions dent or fracture occlusive material on the wall of a vascular lumen and/or patient valve leaflets when expanded. The spacing features permit blood, drug, and contrast perfusion past structures expanded in the vasculature, particularly balloon catheters.
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公开(公告)号：US11654036B2
公开(公告)日：2023-05-23
申请号：US17402357
申请日：2021-08-13
Applicant: Elixir Medical Corporation
Inventor： Motasim Sirhan , Xiaoxia Zheng , Vinayak D. Bhat , John Yan
IPC: A61K31/5377 , A61F2/82 , A61L27/50 , A61L27/54 , A61L31/16 , A61L33/00 , A61L27/20 , A61L27/34 , A61L31/04 , A61L31/10 , A61L33/08 , A61K31/4545 , A61L27/58 , A61F2/844 , A61K31/727 , A61F2/848 , A61K31/4709
CPC classification number: A61F2/844 , A61F2/82 , A61F2/848 , A61K31/4545 , A61K31/4709 , A61K31/5377 , A61K31/727 , A61L27/20 , A61L27/34 , A61L27/507 , A61L27/54 , A61L31/04 , A61L31/042 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L33/08 , A61F2210/0004 , A61F2220/0008 , A61F2250/0035 , A61F2250/0068 , A61L27/58
Abstract: Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.
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公开(公告)号：US20210186722A1
公开(公告)日：2021-06-24
申请号：US17195478
申请日：2021-03-08
Applicant: Elixir Medical Corporation
Inventor： Motasim Sirhan , Vinayak Bhat , Joseph Paraschac , Benjamyn Serna , John Yan
Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.
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公开(公告)号：US20210038411A1
公开(公告)日：2021-02-11
申请号：US17073052
申请日：2020-10-16
Applicant: Elixir Medical Corporation
Inventor： Motasim Sirhan , Vinayak Bhat , Joseph Paraschac , Benjamyn Serna , John Yan
Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.
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公开(公告)号：US10786374B2
公开(公告)日：2020-09-29
申请号：US16518657
申请日：2019-07-22
Applicant: Elixir Medical Corporation
Inventor： Motasim Sirhan , John Yan , Vinayak Bhat , Joseph Paraschac , Brett Cryer , Benjamyn Serna
Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.
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