PROCESS FOR PREPARING 2,2-DIFLUOROETHANOL
    28.
    发明申请
    PROCESS FOR PREPARING 2,2-DIFLUOROETHANOL 有权
    制备2,2-二氟乙醇的方法

    公开(公告)号:US20140243561A1

    公开(公告)日:2014-08-28

    申请号:US14232170

    申请日:2012-07-16

    IPC分类号: C07C29/147

    摘要: Process for preparing 2,2-difluoroethanol, comprising the following steps: reacting 1-chloro-2,2-difluoroethane with an alkali metal salt of formic acid or acetic acid in a suitable solvent to give the corresponding 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate, and transesterifying the 2,2-difluoroethyl formate or 2,2-difluoroethyl acetate from step (i) in the presence of an alcohol and optionally of a base.

    摘要翻译: 制备2,2-二氟乙醇的方法,包括以下步骤:使1-氯-2,2-二氟乙烷与甲酸或乙酸的碱金属盐在合适的溶剂中反应,得到相应的2,2-二氟乙酸甲酯或 并且在醇和任选的碱的存在下,从步骤(i)中酯交换甲酸2,2-二氟乙酯或乙酸2,2-二氟乙酯。