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29 条记录 (耗时 0.026 秒)

    Method of treating calcium overload in brain cells of mammals
    23.
    发明授权
    Method of treating calcium overload in brain cells of mammals 失效
    治疗哺乳动物脑细胞钙超载的方法

    公开(公告)号：US4877799A

    公开(公告)日：1989-10-31

    申请号：US106154

    申请日：1987-10-08

    申请人： Jorgen Drejer ,  Palle Jakobsen

    发明人： Jorgen Drejer ,  Palle Jakobsen

    IPC分类号： A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P3/00 ,  C07D211/20 ,  C07D211/22 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D211/20 ,  C07D211/22

    摘要： Novel piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, C.sub.3-5 -alkylene or aralkoxy,R.sup.1 is straight or branched C.sub.1-8 -alkyl, C.sub.4-8 -alkoxy-C.sub.4-8 -alkyl, C.sub.4-7 -cycloalkyl, aryloxy-C.sub.3-8 -alkyl, C.sub.4-8 -alkenyl, or C.sub.4-8 -cycloalkylalkyl, or R.sup.1 may also be hydrogen or C.sub.1-3 -alkyl, when R.sup.3 is aryl, which is substituted with two or more of C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, aralkoxy, or with C.sub.3-5 -alkylene.X is hydrogen or halogen, and whereinY is O or S or a salt thereof with a pharmaceutically-acceptable acid, pharmaceutical compositions thereof, method-of-treating therewith.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

    摘要翻译： 具有式“IMAGE”的新型哌啶化合物，其中R 3是3,4-亚甲二氧基苯基，芳基或杂芳基，其任选被一个或多个C 1-6 - 烷基，C 1-6 - 烷氧基，C 3-8 - 环烷基，C 3-5 - 亚烷基或芳烷氧基，R 1是直链或支链C 1-8 - 烷基，C 4-8 - 烷氧基-C 4-8 - 烷基，C 4-7 - 环烷基，芳氧基-C 3-8 - 烷基，C 4-8烯基或C 4 -8-环烷基烷基或R 1也可以是氢或C 1-3 - 烷基，当R 3是被两个或多个C 1-6 - 烷基，C 1-6 - 烷氧基，C 3-8 - 环烷基，芳烷氧基 ，或与C 3-5 - 亚烷基。 X是氢或卤素，并且其中Y是O或S或其盐与药学上可接受的酸，其药物组合物，其处理方法。 新型化合物可用于治疗缺氧，偏头痛，局部缺血和癫痫。

    Piperidine compounds and their preparation and use
    25.
    发明授权
    Piperidine compounds and their preparation and use 失效
    哌啶化合物及其制备和用途

    公开(公告)号：US5227379A

    公开(公告)日：1993-07-13

    申请号：US803200

    申请日：1991-12-05

    申请人： Palle Jakobsen ,  Jorgen Drejer

    发明人： Palle Jakobsen ,  Jorgen Drejer

    IPC分类号： C07D211/20 ,  C07D211/22 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14

    CPC分类号： C07D405/12 ,  C07D211/20 ,  C07D211/22 ,  C07D405/14 ,  C07D417/14

    摘要： Piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, phenyl, or naphthyl which are optionally substituted with one or more halogen, C.sub.1-6 -alkoxy, or phenoxy, cyano, mono or poly halogenated C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl, C.sub.1-6 -alkyl, or C.sub.3-5 -alkylene, R.sup.1 is straight or branched C.sub.1-8 -alkyl substituted with piperidinyl morpholinyl thiomorpholinyl dioxolanyl or tetrahydrofuranyl, which heterocyclic radical is unsubstituted or C.sub.1-6 -alkyl substituted,X is hydrogen, halogen, trifluoromethyl, hydroxy, cyano, or C.sub.1-8 -alkoxy,Y is O or S; and pharmaceutically-acceptable acid addition salts thereof.The compounds are useful in the treatment of anoxia, migraine, ischemia, and epilepsy.

    摘要翻译： 具有式（1）的哌啶化合物，其中R 3是任选被一个或多个卤素，C 1-6 - 烷氧基或苯氧基，氰基，单或多卤代C1取代的3,4-亚甲二氧基苯基，苯基或萘基 C6-烷基，C2-6-烯基，C1-6 - 烷基或C3-5 - 亚烷基，R1是被哌啶基吗啉基硫代吗啉基二氧戊环基或四氢呋喃基取代的直链或支链C 1-8 - 烷基，该杂环基是未取代的或C1 6-烷基取代的，X是氢，卤素，三氟甲基，羟基，氰基或C 1-8 - 烷氧基，Y是O或S; 及其药学上可接受的酸加成盐。 该化合物可用于治疗缺氧，偏头痛，局部缺血和癫痫。