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公开(公告)号：US09162024B2
公开(公告)日：2015-10-20
申请号：US12463255
申请日：2009-05-08
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai , Jeffrey Brennan , Raymond Peck
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai , Jeffrey Brennan , Raymond Peck
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include a drug reservoir, a cannula fluidly coupled to the reservoir, a pumping mechanism for forcing liquid from the reservoir through the cannula, control circuitry for operating the pumping mechanism, and a power source comprising primary and auxiliary batteries in a stacked configuration, only the main battery being operatively coupled to the control circuitry during normal operation, the control circuitry operatively coupling the back-up battery upon detection of an electrical fault. The pump may further include a hermetic enclosure containing the control circuitry and the power source.
摘要翻译： 可植入电解泵的实施例包括药物储存器，流体地联接到储存器的套管，用于迫使来自储存器的液体通过套管的泵送机构，用于操作泵送机构的控制电路，以及包括主电池和辅助电池的电源 堆叠配置，在正常操作期间只有主电池可操作地耦合到控制电路，所述控制电路在检测到电气故障时可操作地耦合备用电池。 泵还可以包括包含控制电路和电源的密封外壳。
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公开(公告)号：US09107995B2
公开(公告)日：2015-08-18
申请号：US13912562
申请日：2013-06-07
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.
摘要翻译： 制造可植入泵的方法的实施例，包括提供包括用于容纳药物室的圆顶结构的上层和与药物腔流体连通的套管，提供与药物室相邻的中间偏转层，提供包含电解的底层 电极，并结合上层，中间偏转层和底层，形成泵。
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公开(公告)号：US08684997B2
公开(公告)日：2014-04-01
申请号：US13541012
申请日：2012-07-03
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon.
摘要翻译： 可植入电解泵的实施例包括电解室，药物室和渗透室，渗透室具有与药物室接触的第一部分和暴露于便于与周围流体接触的第二部分。 泵还包括用于从药物腔室导出液体的插管和电解室内的电解电极，用于在其中产生气体，电解和药物室接触，使得电解室内的气体电解迫使来自药物室的流体进入 插管，药物室和渗透室之间的接触，允许从周围流体进入渗透室的流体以抵消药物室的体积损失并防止其上的真空压力的累积。
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公开(公告)号：US08486278B2
公开(公告)日：2013-07-16
申请号：US12463258
申请日：2009-05-08
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
IPC分类号： B81C3/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.
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公开(公告)号：US20090311133A1
公开(公告)日：2009-12-17
申请号：US12463258
申请日：2009-05-08
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.
摘要翻译： 制造可植入泵的方法的实施例，包括提供包括用于容纳药物室的圆顶结构的上层和与药物腔流体连通的套管，提供与药物室相邻的中间偏转层，提供包含电解的底层 电极，并结合上层，中间偏转层和底层，形成泵。
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公开(公告)号：US09861525B2
公开(公告)日：2018-01-09
申请号：US14802503
申请日：2015-07-17
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
IPC分类号： A61M5/00 , A61F9/007 , B44C1/22 , A61M5/142 , A61M5/145 , A61F9/00 , A61M5/14 , A61M5/168 , A61M39/24
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.
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公开(公告)号：US20140196798A1
公开(公告)日：2014-07-17
申请号：US14153662
申请日：2014-01-13
申请人： Yu-Chong Tai , Po-Ying Li , Fukang Jiang , Changlin Pang , Natasha Yvette Bouey , Man Ting Chou , Atoosa Lotfi
发明人： Yu-Chong Tai , Po-Ying Li , Fukang Jiang , Changlin Pang , Natasha Yvette Bouey , Man Ting Chou , Atoosa Lotfi
IPC分类号： F16K15/14
CPC分类号： F16K15/147 , B29C39/10 , B29C41/20 , B29C45/14598 , B29C70/766 , B29L2031/753 , B29L2031/756 , F16K15/145 , F16K99/0057 , F16K2099/0078 , Y10T137/0497 , Y10T137/7895
摘要： Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded to the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.
摘要翻译： 用于例如微型泵装置的微型阀可以由结合到阀管内部的狭缝隔膜形成。 隔膜中的凸起和/或反向泄漏塞子可能增加阀的击穿压力。 推杆可以用于预加载阀膜，从而增加开启压力。
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公开(公告)号：US20130276974A1
公开(公告)日：2013-10-24
申请号：US13912562
申请日：2013-06-07
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark S. Humayun , Yu-Chong Tai
IPC分类号： A61M5/142
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump.
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公开(公告)号：US20120323218A1
公开(公告)日：2012-12-20
申请号：US13541012
申请日：2012-07-03
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon.
摘要翻译： 可植入电解泵的实施例包括电解室，药物室和渗透室，渗透室具有与药物室接触的第一部分和暴露于便于与周围流体接触的第二部分。 泵还包括用于从药物腔室导出液体的插管和电解室内的电解电极，用于在其中产生气体，电解和药物室接触，使得电解室内的气体电解迫使来自药物室的流体进入 插管，药物室和渗透室之间的接触，允许从周围流体进入渗透室的流体以抵消药物室的体积损失并防止其上的真空压力的累积。
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公开(公告)号：US20120277733A1
公开(公告)日：2012-11-01
申请号：US13541005
申请日：2012-07-03
申请人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
发明人： Changlin Pang , Fukang Jiang , Jason Shih , Sean Caffey , Mark Humayun , Yu-Chong Tai
CPC分类号： A61F9/00781 , A61F9/0017 , A61M5/1408 , A61M5/142 , A61M5/14276 , A61M5/14593 , A61M5/16886 , A61M39/24 , A61M2005/14204 , A61M2005/14264 , A61M2205/0244 , A61M2210/0612 , B44C1/227 , Y10T156/1092 , Y10T156/1093 , Y10T307/625
摘要： Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
摘要翻译： 可植入电解泵的实施例包括第一可膨胀隔膜和第二柔性隔膜，以及每个用于容纳流体的第一和第二室，其中第一可膨胀隔膜分隔第一和第二室并在其间提供流体阻挡物，第二室 形成在第一可膨胀膜片和第二柔性膜片之间。 泵还可以包括在第一室内的电解电极，用于在其中产生气体，从而使可膨胀隔膜膨胀，使得流体被迫从第二室进入套管。
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