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公开(公告)号：US20180080578A1
公开(公告)日：2018-03-22
申请号：US15805501
申请日：2017-11-07
申请人： Yu-Chong Tai , Po-Ying Li , Fukang Jiang , Changlin Pang , Natasha Yvette Bouey , Man Ting Chou , Atoosa Lotfi
发明人： Yu-Chong Tai , Po-Ying Li , Fukang Jiang , Changlin Pang , Natasha Yvette Bouey , Man Ting Chou , Atoosa Lotfi
CPC分类号： F16K99/0057 , A61M39/24 , A61M2039/2426 , B29C39/10 , B29C41/20 , B29C45/14598 , B29C70/766 , B29L2031/753 , B29L2031/756 , F16K15/145 , F16K15/147 , F16K99/0015 , F16K2099/0073 , F16K2099/0078 , F16K2099/0086 , Y10T137/0497 , Y10T137/7895
摘要： Microscale valves for use in, e.g., micropump devices, may be formed of a slitted diaphragm bonded o the interior of a valve tube. A bump in the diaphragm and/or a backward-leakage stopper may increase the breakdown pressure of the valve. A push-rod may be used to pre-load the valve membrane to thereby increase the cracking pressure.
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公开(公告)号：US09901687B2
公开(公告)日：2018-02-27
申请号：US13868649
申请日：2013-04-23
CPC分类号： A61M5/427 , A61F9/0017 , A61M5/14276 , A61M5/158 , A61M5/46 , A61M39/0208 , A61M2005/14284 , A61M2039/0238 , A61M2205/3523 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/6054 , A61M2205/6063 , A61M2209/045 , A61M2210/0612
摘要： In various embodiments, a needle is employed in refilling drug-delivery devices.
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公开(公告)号：US20140088554A1
公开(公告)日：2014-03-27
申请号：US14035552
申请日：2013-09-24
申请人： Po-Ying Li , Shengtao Li , Jonathan K. Lee , Patrick Ryan , Alice Lai , Sean Caffey , Mark S. Humayun
发明人： Po-Ying Li , Shengtao Li , Jonathan K. Lee , Patrick Ryan , Alice Lai , Sean Caffey , Mark S. Humayun
IPC分类号： A61M5/172
CPC分类号： A61M5/172 , A61M5/14248 , A61M5/14526 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/3334 , A61M2205/3341 , G06F19/3468
摘要： Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. Depending on the mode of operation, fluid may be dispensed continuously or in discrete pulses, and the manner of adjustment or calibration may be tailored to the operational mode in use.
摘要翻译： 本发明的实施例利用闭环反馈控制系统来确保准确的药物递送。 该控制系统可以例如利用流量传感器来测量输送量，以及智能控制算法来预测和补偿过量和过量。 根据本文的反馈控制系统可以应用于使用直接或间接测量流量的传感器的任何活塞或柱塞驱动的泵系统。 取决于操作模式，流体可以连续分配或以离散脉冲分配，并且调整或校准的方式可以针对使用中的操作模式进行调整。
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公开(公告)号：US20110144619A1
公开(公告)日：2011-06-16
申请号：US13026121
申请日：2011-02-11
申请人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included.
摘要翻译： 用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。 可以包括不依赖于施加到装置的压力来保持通过套管的恒定流速的阀。
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公开(公告)号：US20110060280A1
公开(公告)日：2011-03-10
申请号：US12875266
申请日：2010-09-03
申请人： Sean Caffey , Po-Ying Li , Yu-Chong Tai
发明人： Sean Caffey , Po-Ying Li , Yu-Chong Tai
CPC分类号： A61M37/00 , A61M5/14248 , A61M5/14593 , A61M5/16886 , A61M25/02 , A61M2005/14252 , A61M2205/3334 , A61M2205/3355 , A61M2205/3569 , A61M2205/3592
摘要： In various embodiments, a drug-delivery device includes a skin patch with an integral delivery vehicle adherable to a patient's skin. An exterior surface of the patch defines an envelope within which is disposed a programmable drug pump including a reservoir, a cannula for conducting liquid from the reservoir to the delivery vehicle, and a mechanism for forcing liquid from the reservoir through the cannula and into the delivery vehicle.
摘要翻译： 在各种实施方案中，药物递送装置包括具有可贴合患者皮肤的整体递送载体的皮肤贴片。 贴片的外表面限定了一个封套，其中设置有可编程药物泵，其包括储存器，用于将液体从储存器传送到输送车辆的插管，以及用于迫使来自储存器的液体通过套管并进入输送器的机构 车辆。
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公开(公告)号：US07887508B2
公开(公告)日：2011-02-15
申请号：US11686310
申请日：2007-03-14
申请人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61F7/12
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient includes a reservoir configured to contain a liquid comprising the therapeutic agent and a cannula in fluid communication with the reservoir. The device and related methods may provide such features as constant-flow operation, an electrolytic mode of pumping, and/or wireless communication.
摘要翻译： 用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体和与储存器流体连通的插管的储存器。 该装置和相关方法可以提供诸如恒流操作，电解抽吸模式和/或无线通信之类的特征。
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公开(公告)号：US08920376B2
公开(公告)日：2014-12-30
申请号：US13091031
申请日：2011-04-20
申请人： Sean Caffey , Po-Ying Li , Yu-Chong Tai , Jeffrey Brennan
发明人： Sean Caffey , Po-Ying Li , Yu-Chong Tai , Jeffrey Brennan
CPC分类号： A61M5/14526 , A61M5/14248 , A61M5/14276 , A61M5/14593 , A61M5/1684 , A61M5/16886 , A61M2005/14204 , A61M2205/3523 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2210/0612
摘要： The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.
摘要翻译： 可以使用与储存器边界相关联的机械和/或磁性位置传感器来确定药物泵装置中药物储存器的填充状态。
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公开(公告)号：US20140094771A1
公开(公告)日：2014-04-03
申请号：US14035835
申请日：2013-09-24
申请人： Po-Ying Li , Shengtao Li , Jonathan K. Lee , Patrick Ryan , Alice Lai , Sean Caffey , Mark S. Humayun
发明人： Po-Ying Li , Shengtao Li , Jonathan K. Lee , Patrick Ryan , Alice Lai , Sean Caffey , Mark S. Humayun
IPC分类号： A61M5/172
CPC分类号： A61M5/172 , A61M5/14244 , A61M5/14248 , A61M5/14276 , A61M5/14526 , A61M5/14586 , A61M5/14593 , A61M5/148 , A61M5/155 , A61M5/16804 , A61M5/16809 , A61M5/16854 , A61M5/3146 , A61M31/002 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/0222 , A61M2205/0238 , A61M2205/3331 , A61M2205/3334 , A61M2205/3341 , A61M2205/3368 , A61M2205/50 , A61M2205/8206 , A61M2205/8231 , A61M2205/8293 , A61M2210/0612 , A61M2210/0693 , G06F19/00 , G06F19/3468
摘要： Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made based on the flow “tail” that occurs in a piston- or plunger-type pump as relaxation of the plunger material continues to push fluid out of the drug reservoir; this residual flow eventually ceases after the plunger returns to its natural state.
摘要翻译： 本发明的实施例利用闭环反馈控制系统来确保准确的药物递送。 该控制系统可以例如利用流量传感器来测量输送量，以及智能控制算法来预测和补偿过量和过量。 根据本文的反馈控制系统可以应用于使用直接或间接测量流量的传感器的任何活塞或柱塞驱动的泵系统。 在一些实施例中，基于在活塞或柱塞式泵中发生的流动“尾”进行调整，因为柱塞材料的松弛继续将流体推出药物储存器; 在柱塞恢复到其自然状态之后，该剩余流最终停止。
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公开(公告)号：US20110144617A1
公开(公告)日：2011-06-16
申请号：US13026136
申请日：2011-02-11
申请人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo Monterey Park , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo Monterey Park , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, a cannula in fluid communication with the reservoir, and means for forcing fluid from the reservoir into the cannula. Circuitry for controlling the means for forcing fluid from the reservoir into the cannula may be included.
摘要翻译： 用于将治疗剂递送到患者的可植入装置的实施例包括：储存器，其构造成容纳包含治疗剂的液体，与储存器流体连通的套管，以及用于迫使流体从储存器进入套管的装置。 可以包括用于控制用于将流体从储存器迫使进入套管的装置的电路。
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公开(公告)号：US20100305550A1
公开(公告)日：2010-12-02
申请号：US12790240
申请日：2010-05-28
申请人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M35/00
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
摘要翻译： 用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。 套管被成形为便于将其插入患者眼球。
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