公开(公告)号：US20180118680A1

公开(公告)日：2018-05-03

申请号：US15851322

申请日：2017-12-21

Applicant: Genentech, Inc.

Inventor： Huifen Chen ,  Yanyan Chu ,  Steven Do ,  Anthony Estrada ,  Baihua Hu ,  Aleksandr Kolesnikov ,  Xingyu Lin ,  Joseph P. Lyssikatos ,  Daniel Shore ,  Vishal Verma ,  Lan Wang ,  Guosheng Wu ,  Po-wai Yuen

IPC: C07D207/48 ,  C07D403/14 ,  C07D417/12 ,  C07D403/12 ,  C07D451/02 ,  C07D405/14 ,  C07D401/14 ,  C07D491/048 ,  C07D401/12

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20150165063A1

公开(公告)日：2015-06-18

申请号：US14305643

申请日：2014-06-16

Applicant: Genentech, Inc.

Inventor： John Flygare ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  William Denny ,  Anna Giddens ,  Ho Lee ,  Guo-Liang Lu ,  Christian Miller ,  Gordon Rewcastle ,  Moana Tercel ,  Muriel Bonnet

IPC: A61K47/48 ,  C07K16/18 ,  C07K16/32 ,  C07D401/14 ,  C07K5/062 ,  C07F9/6558 ,  C07D403/14 ,  C07H15/24 ,  C07K16/28 ,  C07D209/62

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

Abstract translation: 本发明提供包含通过接头与1-（氯甲基）-2,3-二氢-1H-苯并[e]吲哚（CBI）二烯体（CBI）二聚体药物部分缀合的抗体的抗体 - 药物偶联物，以及使用抗体药物 共轭物