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公开(公告)号:US09884126B2
公开(公告)日:2018-02-06
申请号:US14284619
申请日:2014-05-22
申请人: Genentech, Inc.
发明人: Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号: A61K47/48 , C07K16/12 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12
CPC分类号: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号:US09999681B2
公开(公告)日:2018-06-19
申请号:US15181825
申请日:2016-06-14
申请人: Genentech, Inc.
发明人: John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben
CPC分类号: A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6889 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/56 , C07K2317/76
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.
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公开(公告)号:US20180016325A1
公开(公告)日:2018-01-18
申请号:US15718876
申请日:2017-09-28
申请人: Genentech, Inc.
发明人: Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号: C07K16/12 , A61K45/06 , A61K39/40 , A61K31/4025 , A61K31/5386
CPC分类号: C07K16/1271 , A61K31/4025 , A61K31/5386 , A61K39/40 , A61K45/06 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号:US20160074529A1
公开(公告)日:2016-03-17
申请号:US14945716
申请日:2015-11-19
申请人: GENENTECH, INC.
发明人: Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号: A61K47/48 , A61K31/7048 , A61K31/4709 , A61K38/12 , A61K31/4375 , A61K31/4436 , A61K31/7056 , A61K31/439
CPC分类号: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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5.1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT 审中-公开
标题翻译: 1-(氯代乙基)-2,3-二氢-1H-苯并[E]吲哚类抗生素联合化合物,以及使用和治疗方法公开(公告)号:US20150165063A1
公开(公告)日:2015-06-18
申请号:US14305643
申请日:2014-06-16
申请人: Genentech, Inc.
发明人: John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
IPC分类号: A61K47/48 , C07K16/18 , C07K16/32 , C07D401/14 , C07K5/062 , C07F9/6558 , C07D403/14 , C07H15/24 , C07K16/28 , C07D209/62
摘要: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
摘要翻译: 本发明提供包含通过接头与1-(氯甲基)-2,3-二氢-1H-苯并[e]吲哚(CBI)二烯体(CBI)二聚体药物部分缀合的抗体的抗体 - 药物偶联物,以及使用抗体药物 共轭物
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公开(公告)号:US10570192B2
公开(公告)日:2020-02-25
申请号:US15718876
申请日:2017-09-28
申请人: Genentech, Inc.
发明人: Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号: C07K16/12 , A61K39/40 , A61K31/5386 , A61K45/06 , A61K31/4025 , A61K47/68
摘要: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
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公开(公告)号:US10533058B2
公开(公告)日:2020-01-14
申请号:US15104388
申请日:2014-12-16
申请人: GENENTECH INC. , MEDIMMUNE LIMITED
发明人: John Flygare , Janet Gunzner-Toste , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , Guiling Zhao , Leanna Staben , Philip Wilson Howard , Luke Masterson
IPC分类号: A61K47/68 , A61K31/5517 , C07K16/30 , C07K16/28
摘要: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, pharmaceutical compositions containing them, and to their use in therapy for the prevention treatment of cancer.
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公开(公告)号:US20150366985A1
公开(公告)日:2015-12-24
申请号:US14284619
申请日:2014-05-22
申请人: GENENTECH, INC.
发明人: Eric J. Brown , John Flygare , Wouter Hazenbos , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号: A61K47/48 , A61K31/395
CPC分类号: A61K47/6849 , A61K31/395 , A61K31/4375 , A61K31/439 , A61K31/4436 , A61K31/4709 , A61K31/7048 , A61K31/7056 , A61K38/12 , A61K47/6801 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K47/6851 , C07K16/1271 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
摘要翻译: 本发明提供了抗壁磷壁酸抗体及其抗生素缀合物及其使用方法。
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公开(公告)号:US20140356375A1
公开(公告)日:2014-12-04
申请号:US14284609
申请日:2014-05-22
申请人: GENENTECH, INC.
发明人: Eric J. Brown , Martine Darwish , John Flygare , Wouter Hazenbos , Byoung Chul Lee , Sophie M. Lehar , Sanjeev Mariathasan , John Hiroshi Morisaki , Thomas H. Pillow , Leanna Staben , Richard Vandlen , Klaus Koefoed , Magnus Strandh , Peter S. Andersen
IPC分类号: C07K16/12 , A61K39/40 , A61K31/5383 , A61K47/48
CPC分类号: C07K16/1271 , A61K31/5383 , A61K47/6809 , A61K47/6835 , C07K2317/21 , C07K2317/522 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/624 , C07K2317/92
摘要: The invention provides anti-wall teichoic acid antibodies and antibiotic conjugates thereof, and methods of using the same.
摘要翻译: 本发明提供了抗壁磷壁酸抗体及其抗生素缀合物及其使用方法。
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公开(公告)号:US10442836B2
公开(公告)日:2019-10-15
申请号:US14305643
申请日:2014-06-16
申请人: Genentech, Inc.
发明人: John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
IPC分类号: A61K47/68 , C07K16/28 , C07D207/40 , C07D209/60 , C07K5/062 , C07D487/04 , C07D209/62 , C07D401/14 , C07D403/14 , C07F9/6558 , C07H15/24 , C07K16/32 , C07D401/12 , C07D471/04 , C07K16/00 , C07K16/30 , A61K47/55 , C07F9/572 , C07F9/6561
摘要: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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