公开(公告)号：US20190083643A1

公开(公告)日：2019-03-21

申请号：US16150623

申请日：2018-10-03

Applicant: Genentech, Inc.

Inventor： Ho Huat Lee ,  Moana Tercel ,  John A. Flygare ,  Janet Gunzner-Toste ,  Thomas H. Pillow ,  Brian Safina ,  Leanna Staben ,  Vishal Verma ,  BinQing Wei ,  Guiling Zhao

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

公开(公告)号：US20150165063A1

公开(公告)日：2015-06-18

申请号：US14305643

申请日：2014-06-16

Applicant: Genentech, Inc.

Inventor： John Flygare ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  William Denny ,  Anna Giddens ,  Ho Lee ,  Guo-Liang Lu ,  Christian Miller ,  Gordon Rewcastle ,  Moana Tercel ,  Muriel Bonnet

IPC: A61K47/48 ,  C07K16/18 ,  C07K16/32 ,  C07D401/14 ,  C07K5/062 ,  C07F9/6558 ,  C07D403/14 ,  C07H15/24 ,  C07K16/28 ,  C07D209/62

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

Abstract translation: 本发明提供包含通过接头与1-（氯甲基）-2,3-二氢-1H-苯并[e]吲哚（CBI）二烯体（CBI）二聚体药物部分缀合的抗体的抗体 - 药物偶联物，以及使用抗体药物 共轭物

公开(公告)号：US10442836B2

公开(公告)日：2019-10-15

申请号：US14305643

申请日：2014-06-16

Applicant: Genentech, Inc.

Inventor： John Flygare ,  Thomas Pillow ,  Brian Safina ,  Vishal Verma ,  Binqing Wei ,  William Denny ,  Anna Giddens ,  Ho Lee ,  Guo-Liang Lu ,  Christian Miller ,  Gordon Rewcastle ,  Moana Tercel ,  Muriel Bonnet

IPC: A61K47/68 ,  C07K16/28 ,  C07D207/40 ,  C07D209/60 ,  C07K5/062 ,  C07D487/04 ,  C07D209/62 ,  C07D401/14 ,  C07D403/14 ,  C07F9/6558 ,  C07H15/24 ,  C07K16/32 ,  C07D401/12 ,  C07D471/04 ,  C07K16/00 ,  C07K16/30 ,  A61K47/55 ,  C07F9/572 ,  C07F9/6561

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

公开(公告)号：US10544215B2

公开(公告)日：2020-01-28

申请号：US15182444

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： John A. Flygare ,  Thomas H. Pillow ,  Brian Safina ,  Vishal Verma ,  BinQing Wei ,  William Denny ,  Anna Giddens ,  Ho Lee ,  Guo-Liang Lu ,  Christian Miller ,  Gordon Rewcastle ,  Moana Tercel ,  Muriel Bonnet

IPC: A61K47/68 ,  C07K16/28

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

公开(公告)号：US20160354485A1

公开(公告)日：2016-12-08

申请号：US15182444

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： John A. Flygare ,  Thomas H. Pillow ,  Brian Safina ,  Vishal Verma ,  BinQing Wei ,  William Denny ,  Anna Giddens ,  Ho Lee ,  Guo-Liang Lu ,  Christian Miller ,  Gordon Rewcastle ,  Moana Tercel ,  Muriel Bonnet

IPC: A61K47/48 ,  C07K16/28

CPC classification number: C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6869 ,  C07D209/60 ,  C07D403/14 ,  C07D487/04 ,  C07F9/65583 ,  C07F9/6561 ,  C07K2317/56

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

公开(公告)号：US20160279261A1

公开(公告)日：2016-09-29

申请号：US15182429

申请日：2016-06-14

Applicant: Ho Huat Lee ,  Moana Tercel ,  Genentech, Inc.

Inventor： Ho Huat Lee ,  Moana Tercel ,  John A. Flygare ,  Janet Gunzner-Toste ,  Thomas H. Pillow ,  Brian Safina ,  Leanna Staben ,  Vishal Verma ,  BinQing Wei ,  Guiling Zhao

IPC: A61K47/48 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2851 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

公开(公告)号：US10124069B2

公开(公告)日：2018-11-13

申请号：US15182429

申请日：2016-06-14

Applicant: Genentech, Inc.

Inventor： Ho Huat Lee ,  Moana Tercel ,  John A. Flygare ,  Janet Gunzner-Toste ,  Thomas H. Pillow ,  Brian Safina ,  Leanna Staben ,  Vishal Verma ,  BinQing Wei ,  Guiling Zhao

IPC: A61K47/00 ,  A61K47/48 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  A61K39/00

Abstract: This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.