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![1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/abs-image/US/2020/01/28/US10544215B2/abs.jpg.150x150.jpg)
公开(公告)号：US10544215B2
公开(公告)日：2020-01-28
申请号：US15182444
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： John A. Flygare , Thomas H. Pillow , Brian Safina , Vishal Verma , BinQing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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![1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT](/abs-image/US/2016/12/08/US20160354485A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20160354485A1
公开(公告)日：2016-12-08
申请号：US15182444
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： John A. Flygare , Thomas H. Pillow , Brian Safina , Vishal Verma , BinQing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6849 , A61K47/6869 , C07D209/60 , C07D403/14 , C07D487/04 , C07F9/65583 , C07F9/6561 , C07K2317/56
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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![1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT](/abs-image/US/2015/06/18/US20150165063A1/abs.jpg.150x150.jpg)
3.发明申请1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT 审中-公开1-（氯代乙基）-2,3-二氢-1H-苯并[E]吲哚类抗生素联合化合物，以及使用和治疗方法公开(公告)号：US20150165063A1
公开(公告)日：2015-06-18
申请号：US14305643
申请日：2014-06-16
Applicant: Genentech, Inc.
Inventor： John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
IPC: A61K47/48 , C07K16/18 , C07K16/32 , C07D401/14 , C07K5/062 , C07F9/6558 , C07D403/14 , C07H15/24 , C07K16/28 , C07D209/62
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
Abstract translation: 本发明提供包含通过接头与1-（氯甲基）-2,3-二氢-1H-苯并[e]吲哚（CBI）二烯体（CBI）二聚体药物部分缀合的抗体的抗体 - 药物偶联物，以及使用抗体药物 共轭物
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![1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/abs-image/US/2019/10/15/US10442836B2/abs.jpg.150x150.jpg)
公开(公告)号：US10442836B2
公开(公告)日：2019-10-15
申请号：US14305643
申请日：2014-06-16
Applicant: Genentech, Inc.
Inventor： John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
IPC: A61K47/68 , C07K16/28 , C07D207/40 , C07D209/60 , C07K5/062 , C07D487/04 , C07D209/62 , C07D401/14 , C07D403/14 , C07F9/6558 , C07H15/24 , C07K16/32 , C07D401/12 , C07D471/04 , C07K16/00 , C07K16/30 , A61K47/55 , C07F9/572 , C07F9/6561
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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