Antimicrobially active 4-methyl-4-aryl-2-pentanols, their preparation and use
    25.
    发明授权
    Antimicrobially active 4-methyl-4-aryl-2-pentanols, their preparation and use 有权
    抗微生物活性的4-甲基-4-芳基-2-戊醇,其制备和应用

    公开(公告)号:US07119123B2

    公开(公告)日:2006-10-10

    申请号:US10790770

    申请日:2004-03-03

    IPC分类号: A61K31/045

    摘要: Antimicrobially active 4-methyl-4-aryl-2-pentanols of the Formula 1 below, methods for the preparation of these compounds and their use as antimicrobial active compounds are described. Surprisingly, compounds of the Formula 1 for which: R=hydrogen, hydroxyl, alkoxy group with up to 10 C atoms, straight-chain or branched, saturated or unsaturated alkyl with up to 10 C atoms, alkylthioether group with up to 10 C atoms, the alkylthioether group being bonded to the aromatic ring via a thioether bridge, fluorine, chlorine, bromine, iodine, or alkyl with up to 10 C atoms that is interrupted by one or more oxygen and/or sulphur atoms, have proved to be antimicrobially active.

    摘要翻译: 描述了下式1的抗微生物活性的4-甲基-4-芳基-2-戊醇,这些化合物的制备方法及其作为抗微生物活性化合物的用途。 令人惊奇的是,其中:R =氢,羟基,至多10个碳原子的烷氧基,具有至多10个C原子的直链或支链,饱和或不饱和的烷基,具有高达10 C原子的烷硫醚基的式1化合物 通过硫醚桥,氟,氯,溴,碘或具有多达10个C原子的被一个或多个氧和/或硫原子间隔的烷基,烷基硫醚基团与芳环结合,已被证明是抗微生物 活性。