公开(公告)号：US20220233856A1

公开(公告)日：2022-07-28

申请号：US17619221

申请日：2020-06-17

Applicant: Galvani Bioelectronics Limited

Inventor： Isha Gupta ,  Matteo Donega

IPC: A61N1/36 ,  A61N1/05

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging, shock, acute respiratory distress syndrome (ARDS), severe respiratory distress syndrome (SARS), and coronavirus disease 19 (COVID-19).

公开(公告)号：US20250128064A1

公开(公告)日：2025-04-24

申请号：US18930609

申请日：2024-10-29

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Eric Irwin ,  Daniel John Chew ,  Matteo Donega ,  Cindy Cleypool ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/08

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro-and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

公开(公告)号：US20240390678A1

公开(公告)日：2024-11-28

申请号：US18790835

申请日：2024-07-31

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.

公开(公告)号：US20240350809A1

公开(公告)日：2024-10-24

申请号：US18742863

申请日：2024-06-13

Applicant: Galvani Bioelectronics Limited

Inventor： David Karl Lee Peterson ,  Daniel John Chew ,  Matteo Donega ,  Xu Meng

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36167 ,  A61N1/0551

Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period.

公开(公告)号：US20230285752A1

公开(公告)日：2023-09-14

申请号：US18141045

申请日：2023-04-28

Applicant: Galvani Bioelectronics Limited

Inventor： Daniel John Chew ,  Matteo Donega ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/20

CPC classification number: A61N1/36071 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/205 ,  A61N1/36135 ,  A61N1/3616 ,  A61N1/36171

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.

公开(公告)号：US11745010B2

公开(公告)日：2023-09-05

申请号：US15733277

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited ,  UCL Business LTD

Inventor： Matteo Donega ,  Daniel Chew ,  David Holder ,  Kirill Aristovich

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0556 ,  A61N1/36053 ,  A61N1/36135 ,  A61N1/36167 ,  A61N1/3611 ,  A61N1/36114

Abstract: A nerve stimulation system including at least one nerve interface device is disclosed. The device includes a cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the cuff portion, each ring of electrodes including a plurality of electrodes, and wherein each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The system includes a stimulation device in communication with the pairs of electrodes to generate different electrical signals for the pairs of electrodes and a control system that causes the different signals to causes different physiological responses.

公开(公告)号：US11738196B2

公开(公告)日：2023-08-29

申请号：US17872432

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Eric Irwin ,  Daniel John Chew ,  Matteo Donega ,  Cindy Cleypool ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/08

CPC classification number: A61N1/3606 ,  A61N1/0556 ,  A61N1/3614 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/36178 ,  A61N2001/083

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

公开(公告)号：US11589827B2

公开(公告)日：2023-02-28

申请号：US16622675

申请日：2018-06-22

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UCL BUSINESS LTD

Inventor： Kirill Aristovich ,  David Holder ,  Daniel Chew ,  Matteo Donega

IPC: A61B5/00 ,  G16H20/30 ,  G16H40/67 ,  G16H50/20 ,  A61B5/11 ,  A61N1/36 ,  A61B5/388 ,  A61N1/05

Abstract: There is provided a nerve activity monitoring method that includes receiving an input signal indicative of activity in a nerve of a subject; receiving physiological data indicative of physiological activity in the subject; establishing a relationship between the physiological data and the input signal; identifying a plurality of periodic portions in the input signal based on the relationship between the physiological data and the input signal; and outputting the periodic portions identified.

公开(公告)号：US20220409890A1

公开(公告)日：2022-12-29

申请号：US17872829

申请日：2022-07-25

Applicant: Galvani Bioelectronics Limited

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/378

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.

公开(公告)号：US11452867B2

公开(公告)日：2022-09-27

申请号：US16955331

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Matteo Donega ,  Daniel John Chew ,  Margarita J. Vervoordeldonk ,  Isha Gupta

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36 ,  A61N1/378

Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.