公开(公告)号：US20240225519A9

公开(公告)日：2024-07-11

申请号：US18403768

申请日：2024-01-04

Applicant: Nervio Ltd.

Inventor： Einat KERMANY ,  Nir ZARCHI ,  Omer ZARCHI

IPC: A61B5/388 ,  A61B5/00

CPC classification number: A61B5/388 ,  A61B5/7264 ,  A61B5/7282

Abstract: Aspects of embodiments pertain to systems configured to perform neuromonitoring data analysis, by employing the following: receiving patient data comprising data that are descriptive of at least one physical stimulus applied to a mammalian subject for responsively generating at least one signal in a plurality of neural structures of the subject's nervous system; and sensor data descriptive of at least one neurophysiological response signal generated in response the applied physical stimulus. The systems are further configured to determine, based on the received patient data descriptive of the at least one physical stimulus and the generated response signal, at least one characteristic with respect to at least one of the plurality of neural structures of the patient.

公开(公告)号：US20240131327A1

公开(公告)日：2024-04-25

申请号：US18537151

申请日：2023-12-12

Applicant: Galvani Bioelectronics Limited

Inventor： Michael John Carr ,  Kevin K. Kwong ,  Gerald E. Hunsberger

IPC: A61N1/20 ,  A61B5/00 ,  A61B5/08 ,  A61B5/087 ,  A61B5/091 ,  A61B5/145 ,  A61B5/388 ,  A61N1/36

CPC classification number: A61N1/205 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/388 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/3611 ,  A61N1/36171 ,  A61B5/08

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which signals are delivered to the vagus nerve in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US20240082534A1

公开(公告)日：2024-03-14

申请号：US18482806

申请日：2023-10-06

Applicant: Massachusetts Institute of Technology

Inventor： James DICARLO ,  Pouya BASHIVAN ,  Kohitij KAR

IPC: A61M21/00 ,  A61B5/00 ,  A61B5/378 ,  A61B5/388

CPC classification number: A61M21/00 ,  A61B5/378 ,  A61B5/388 ,  A61B5/7264 ,  A61B5/24 ,  A61B2562/028 ,  A61M2021/005 ,  A61M2230/10 ,  A61M2250/00

Abstract: Techniques for non-invasively controlling targeted neural activity of a subject are provided herein. The techniques include applying a stimulus input to the subject, the stimulus input being formed by a deep artificial neural network (ANN) model and being configured to elicit targeted neural activity within a brain of the subject. The stimulus input may be a pattern of luminous power generated by the deep ANN model and applied to retinae of the subject. The stimulus input may be generated by the deep ANN model based on a mapping of the subject's neural responses to neurons of the deep ANN model.

公开(公告)号：US20240023872A1

公开(公告)日：2024-01-25

申请号：US18223785

申请日：2023-07-19

Applicant: VANDERBILT UNIVERSITY

Inventor： Graham Throckmorton ,  Eric Duco Jansen ,  Anita Mahadevan-Jansen

IPC: A61B5/388 ,  A61B5/395

CPC classification number: A61B5/388 ,  A61B5/395

Abstract: Aspects of this invention relate to a system and method of neural stimulation for intraoperative nerve monitoring for a living subject. The system includes an optical source configured to generate light; a delivering means coupled to the optical source to deliver the generated light to a target nerve of the living subject for stimulating the target nerve; and a detector coupled to the target nerve to record evoked signals responsive to the stimulation for intraoperatively monitoring of the target nerve.

公开(公告)号：US20240016437A1

公开(公告)日：2024-01-18

申请号：US18221374

申请日：2023-07-12

Applicant: Advaned Neuromodulation Systems, Inc.

Inventor： Mingming Zhang ,  Hyun-Joo Park ,  Erika Ross ,  Ameya Nanivadekar ,  Nishant Verma

IPC: A61B5/388 ,  A61N1/36

CPC classification number: A61B5/388 ,  A61N1/36139 ,  A61N1/36062 ,  A61N1/36071

Abstract: Systems and methods are disclosed for conducting spinal cord stimulation or other neurostimulation and sensing evoked compound action potential (ECAP) signals. The sensed signals may be processed to isolate ECAP features from noise and/or interfering signals. The isolated ECAP features may be used to control neurostimulation therapy for the patient, such as to quantify or measure lead migration and adjust a neurostimulation therapy for the patient to account for an impact of any detected lead migration, or other purposes (e.g., to guide an implant procedure).

公开(公告)号：US20230398349A1

公开(公告)日：2023-12-14

申请号：US18250340

申请日：2021-10-15

Applicant: Cochlear Limited

Inventor： Paul Michael Carter ,  Daniel Smyth ,  Wolfram Frederik Dueck ,  Stefan Jozef Mauger

IPC: A61N1/32 ,  A61N1/36 ,  A61N1/05 ,  A61B5/0536 ,  A61B5/388 ,  A61B5/00

CPC classification number: A61N1/327 ,  A61N1/36038 ,  A61N1/0541 ,  A61B5/0536 ,  A61B5/388 ,  A61B5/686 ,  A61B5/0071

Abstract: A method includes receiving information regarding a position and/or an orientation of an implantable device relative to a body portion of a recipient during and/or after implantation of at least a portion of the device on and/or into the body portion. The device includes a plurality of electrodes configured to apply electroporation to first cells of the body portion while not damaging second cells of the body portion. The method includes estimating, in response at least in part to the information, first interactions of the electrodes with respect to the first cells. The method further includes estimating, in response at least in part to the information, second interactions of the electrodes with respect to the second cells. The method further includes generating, in response at least in part to the estimated first interactions and the estimated second interactions, values of electrical parameters configured to be provided to the plurality of electrodes to electroporate to the first cells while not damaging the second cells.

公开(公告)号：US20230329948A1

公开(公告)日：2023-10-19

申请号：US18340753

申请日：2023-06-23

Applicant: SafeOp Surgical, Inc.

Inventor： Dan Stashuk ,  Richard A. O'Brien

IPC: A61G13/02 ,  A61B5/00 ,  A61M16/01 ,  A61B5/24 ,  A61B5/377 ,  A61N1/36 ,  A61B5/383 ,  A61B5/246 ,  A61B5/388

CPC classification number: A61G13/02 ,  A61B5/4041 ,  A61B5/4821 ,  A61M16/01 ,  A61B5/24 ,  A61B5/377 ,  A61N1/3605 ,  A61B5/383 ,  A61B5/246 ,  A61B5/388 ,  A61B5/021

Abstract: An automated EP analysis apparatus for monitoring, detecting and identifying changes (adverse or recovering) to a physiological system generating the analyzed EPs, wherein the apparatus is adapted to characterize and classify EPs and create alerts of changes (adverse or recovering) to the physiological systems generating the EPs if the acquired EP waveforms change significantly in latency, amplitude or morphology.

公开(公告)号：US11685884B2

公开(公告)日：2023-06-27

申请号：US16633511

申请日：2017-12-13

Applicant: Tamagawa Academy & University

Inventor： Yutaka Sakai ,  Yoshikazu Isomura

IPC: C12M1/34 ,  A61N5/06 ,  C12N5/0793 ,  A61B5/00 ,  A61B5/311 ,  A61B5/388

CPC classification number: C12M1/34 ,  A61B5/00 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/311 ,  A61B5/388 ,  A61B5/4041 ,  A61B5/4094 ,  A61N5/0622 ,  C12N5/0619

Abstract: The purpose of the present invention is to provide a technique whereby multiple projection targets are efficiently identified from multiple neurons in multiple brain areas with the use of multis-point light stimulation. An acquisition unit 52 acquires spike signals generated from multiple neurons existing in the vicinity of two or more recording sites. A stimulation control unit 51 selects one projection target candidate from two or more candidates in accordance with a definite system on the basis of the spike signals and then determines irradiation timing of light stimulation. Upon the light stimulation, a management unit 53 acquires the spike signals in all of the recording sites within a definite period of time before or after the light stimulation, while dividing the spike signals into anti responses and collision responses. An anti response management unit 81 acquires and manages information relating to the anti responses. A collision response management unit 82 acquires and manages information relating to the collision responses. A priority control section 54 corrects and determines priority depending on the anti response information and the collision response information.

公开(公告)号：US20230031100A1

公开(公告)日：2023-02-02

申请号：US17863480

申请日：2022-07-13

Applicant: Moshe OFER

Inventor： Moshe OFER

IPC: G06F3/01 ,  A61B5/388 ,  A61B5/369 ,  G06F3/16

Abstract: A processing device is configured to interface with a region of the brain of a subject that is responsible for forming concepts without sensory input. The processing device receives brain signals representative of at least one concept formed by the region of the brain without sensory input, and processes the received brain signals so as to convert the at least one concept to data that is representative of a tangible form of the at least one concept. In certain embodiments, the processing device processes data that is representative of at least one concept to be formed by the region so as to convert the data into one or more brain signals, and selectively providing the one or more brain signals to the region of the brain such that the at least one concept represented by the data is formed by the region of the brain without sensory input.

公开(公告)号：US20230026175A1

公开(公告)日：2023-01-26

申请号：US17813731

申请日：2022-07-20

Applicant: CIRCLE SAFE

Inventor： Frédéric FRANCESCHI ,  Bertrand THIERY

IPC: A61B5/388 ,  A61B5/366 ,  A61B5/00

Abstract: The disclosure relates to a computer-implemented method for monitoring diaphragmatic response to phrenic nerve stimulation. The method comprises receiving in real-time a diaphragmatic CMAP signal. The method comprises computing a baseline value of a characteristic of the CMAP signal. The characteristic represents a diaphragmatic response intensity to a phrenic nerve stimulation. The method comprises determining a threshold value of the characteristic, representing a boundary of values of the characteristic indicative of upcoming diaphragmatic palsy. The determining of the threshold value includes shifting the baseline value. The method comprises receiving in real-time a ECG signal. The method comprises repeating in real-time: detecting a QRS complex in the ECG signal, monitoring the CMAP signal, computing a real-time value of the characteristic, comparing the real-time value to the threshold value, and outputting an alert when the threshold is passed. The real-time value of the characteristic is asynchronous to the QRS complex.