公开(公告)号：US11021467B2

公开(公告)日：2021-06-01

申请号：US14735244

申请日：2015-06-10

申请人： Gilead Sciences, Inc.

发明人： Shaopei Cai ,  Zhimin Du ,  Musong Kim ,  Jennifer A. Loyer-Drew ,  Devan Naduthambi ,  Leena Patel ,  Barton W. Phillips ,  Gary Phillips ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Joshua Van Veldhuizen ,  William J. Watkins ,  Suet Chung Yeung

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D473/34 ,  C07D487/04 ,  C07D513/04 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, W, A′, B′, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

公开(公告)号：US20150361068A1

公开(公告)日：2015-12-17

申请号：US14735244

申请日：2015-06-10

申请人： Gilead Sciences, Inc.

发明人： Shaopei Cai ,  Zhimin Du ,  Musong Kim ,  Jennifer A. Loyer-Drew ,  Devan Naduthambi ,  Leena Patel ,  Barton W. Phillips ,  Gary Phillips ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Joshua Van Veldhuizen ,  William J. Watkins ,  Suet Chung Yeung

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D487/04 ,  C07D413/14 ,  C07D405/14 ,  C07D473/34 ,  C07D401/14 ,  C07D513/04 ,  C07D471/04

CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D513/04

摘要： The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, W, A′, B′, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

摘要翻译： 本申请提供式（J）化合物或其药学上可接受的盐，异构体，互变异构体或其混合物，其中本文描述了n，W，A'，B'，R 1，R 2和R 3。 这些化合物是磷脂酰肌醇3-激酶（PI3K）活性的抑制剂，可用于治疗由一种或多种PI3K同种型介导的病症。 本申请还提供包含式（I）化合物或其药学上可接受的盐，异构体，互变异构体或其混合物的药物组合物，以及使用这些化合物和组合物治疗由一种或多种PI3K同种型介导的病症的方法。