公开(公告)号：US07851202B2

公开(公告)日：2010-12-14

申请号：US10588493

申请日：2005-01-27

申请人： Maximilian Fleischer ,  Corinna Haindl ,  Hans Meixner ,  Elfriede Simon

发明人： Maximilian Fleischer ,  Corinna Haindl ,  Hans Meixner ,  Elfriede Simon

IPC分类号： C12M1/34 ,  C12M1/00 ,  C12Q1/26 ,  C12Q1/70

CPC分类号： G01N33/5438

摘要： A biosensor for detecting an antigen using an antigen/antibody coupling includes: a silicon substrate, at least one interdigital electrode pair structure that is located on the silicon substrate, the electrode pair being interspaced at a maximum distance of 1.0 μm; a counter-electrode on the silicon substrate; a reference electrode; a first layer of protein, covering at least the interdigital electrode structure; a selective second protein layer applied to the first layer and containing a capture antibody selected specifically with respect to the antigen of interest and to which the antigen can be coupled. A sensor signal can be read on the interdigital electrode structure, if the antigen is coupled to the capture antibody by way of a sample to be analyzed that comes into contact with the biosensor and a redox reactive molecule is enzymatically released on the sensor surface by an enzyme-marked detection antibody likewise coupled to the antigen.

摘要翻译： 用于使用抗原/抗体偶联检测抗原的生物传感器包括：硅衬底，位于硅衬底上的至少一个叉指电极对结构，电极对间隔1.0μm的最大距离; 在硅衬底上的对电极; 参考电极; 蛋白质的第一层，至少覆盖指状电极结构; 选择性第二蛋白质层，其施加到第一层并且含有相对于感兴趣的抗原特异性选择的抗体可以偶联的捕获抗体。 如果抗原通过与生物传感器接触的待分析样品与捕获抗体偶联，并且氧化还原反应性分子在传感器表面上被酶促释放，则可以在叉指电极结构上读取传感器信号 同样与抗原偶联的酶标记检测抗体。

公开(公告)号：US07707869B2

公开(公告)日：2010-05-04

申请号：US11587172

申请日：2005-04-21

申请人： Maximilian Fleischer ,  Hans Meixner ,  Elfriede Simon ,  Uwe Lampe ,  Roland Pohle

发明人： Maximilian Fleischer ,  Hans Meixner ,  Elfriede Simon ,  Uwe Lampe ,  Roland Pohle

IPC分类号： G01N33/00 ,  B01L5/00

CPC分类号： G01N33/0013 ,  G01N27/4143

摘要： An operating method is disclosed for the selective detection of a target gas in a gas mixture to be measured by a field effect transistor with a gas-sensitive layer disposed on a carrier substrate, wherein the gas mixture to be measured is prepared by an electrochemical element such that the measured gas mixture includes minimal amounts of interfering gases that interfere with the measurement of the target gas, and/or at least one target gas is activated such that it is detected by the gas-sensitive layer.

摘要翻译： 公开了一种操作方法，用于选择性地检测待由气体敏感层设置在载体基底上的场效应晶体管测量的气体混合物中的目标气体，其中待测量的气体混合物由电化学元素 使得测量的气体混合物包括干扰目标气体测量的最小量的干扰气体，和/或至少一个目标气体被激活，使得其被气敏层检测到。

公开(公告)号：US20090127100A1

公开(公告)日：2009-05-21

申请号：US12330955

申请日：2008-12-09

申请人： Maximilian Fleischer ,  Gabor Kiss ,  Hans Meixner ,  Uwe Lampe

发明人： Maximilian Fleischer ,  Gabor Kiss ,  Hans Meixner ,  Uwe Lampe

IPC分类号： C23C14/16

CPC分类号： G08B17/117 ,  G01N27/4141

摘要： An FET-based gas sensor includes at least one field-effect transistor and at least one gas-sensitive layer and a reference layer. Any changes in work function occurring when materials of the layers are exposed to a gas are used to trigger the field-effect structures. The gas-sensitive layer includes a metal oxide having an oxidation catalyst on its surface and accessible to the measured gas.

摘要翻译： 基于FET的气体传感器包括至少一个场效应晶体管和至少一个气体敏感层和参考层。 用于暴露于气体的层的材料发生的作用函数的任何变化被用于触发场效应结构。 气敏层包括其表面上具有氧化催化剂的金属氧化物，并且可被测量的气体接近。

公开(公告)号：US07459732B2

公开(公告)日：2008-12-02

申请号：US11396243

申请日：2006-03-31

申请人： Maximilian Fleischer ,  Uwe Lampe ,  Hans Meixner ,  Roland Pohle ,  Ralf Schneider ,  Elfriede Simon

发明人： Maximilian Fleischer ,  Uwe Lampe ,  Hans Meixner ,  Roland Pohle ,  Ralf Schneider ,  Elfriede Simon

IPC分类号： H01L27/108

CPC分类号： G01N27/002 ,  G01N27/414

摘要： A gas-sensitive field-effect transistor may be formed from a substrate with a gas-sensitive layer and a transistor processed separately and then assembled. The substrate may be patterned to form spacers by which the height of an air gap between the transistor and the sensitive layer may be adjustable to a relatively precise degree. Formation of the spacers can be achieved by patterning the substrate using material-removal techniques. The height of the spacers may be adjusted in the layer thickness of the gas-sensitive layer and for the transistor fabricated using a CMOS process. Suitable techniques for producing recesses between the spacers include, for example, polishing, cutting, sandblasting, lithographic dry etching, or wet-chemical etching. Suitable materials for the substrate may include, for example, glass, ceramic, aluminum oxide, silicon, or a dimensionally stable polymer. Following preparation of the substrate and the transistor, the two elements of the transistor are joined, for example, using flip-chip methods or adhesive-bonding technology.

摘要翻译： 气体敏感场效应晶体管可以由具有气体敏感层的衬底和分开处理的晶体管形成，然后组装。 衬底可以被图案化以形成间隔物，通过该间隔物，晶体管和敏感层之间的气隙的高度可以相对精确地调节。 可以通过使用材料去除技术对衬底进行图案化来实现间隔物的形成。 间隔物的高度可以在气敏层的层厚度和使用CMOS工艺制造的晶体管中进行调整。 用于在间隔件之间产生凹槽的合适技术包括例如抛光，切割，喷砂，光刻干蚀刻或湿法化学蚀刻。 用于基材的合适材料可以包括例如玻璃，陶瓷，氧化铝，硅或尺寸稳定的聚合物。 在准备衬底和晶体管之后，晶体管的两个元件例如使用倒装芯片方法或粘接技术连接。

公开(公告)号：US20060260737A1

公开(公告)日：2006-11-23

申请号：US11396243

申请日：2006-03-31

申请人： Maximilian Fleischer ,  Uwe Lampe ,  Hans Meixner ,  Roland Pohle ,  Ralf Schneider ,  Elfriede Simon

发明人： Maximilian Fleischer ,  Uwe Lampe ,  Hans Meixner ,  Roland Pohle ,  Ralf Schneider ,  Elfriede Simon

IPC分类号： B32B37/00

CPC分类号： G01N27/002 ,  G01N27/414

摘要： A gas-sensitive field-effect transistor may be formed from a substrate with a gas-sensitive layer and a transistor processed separately and then assembled. The substrate may be patterned to form spacers by which the height of an air gap between the transistor and the sensitive layer may be adjustable to a relatively precise degree. Formation of the spacers can be achieved by patterning the substrate using material-removal techniques. The height of the spacers may be adjusted in the layer thickness of the gas-sensitive layer and for the transistor fabricated using a CMOS process. Suitable techniques for producing recesses between the spacers include, for example, polishing, cutting, sandblasting, lithographic dry etching, or wet-chemical etching. Suitable materials for the substrate may include, for example, glass, ceramic, aluminum oxide, silicon, or a dimensionally stable polymer. Following preparation of the substrate and the transistor, the two elements of the transistor are joined, for example, using flip-chip methods or adhesive-bonding technology.

摘要翻译： 气体敏感场效应晶体管可以由具有气体敏感层的衬底和分开处理的晶体管形成，然后组装。 衬底可以被图案化以形成间隔物，通过该间隔物，晶体管和敏感层之间的气隙的高度可以相对精确地调节。 可以通过使用材料去除技术对衬底进行图案化来实现间隔物的形成。 间隔物的高度可以在气敏层的层厚度和使用CMOS工艺制造的晶体管中进行调整。 用于在间隔件之间产生凹槽的合适技术包括例如抛光，切割，喷砂，光刻干蚀刻或湿法化学蚀刻。 用于基材的合适材料可以包括例如玻璃，陶瓷，氧化铝，硅或尺寸稳定的聚合物。 在准备衬底和晶体管之后，晶体管的两个元件例如使用倒装芯片方法或粘接技术连接。

公开(公告)号：US06235243B1

公开(公告)日：2001-05-22

申请号：US07928443

申请日：1992-08-12

申请人： Maximilian Fleischer ,  Hans Meixner

发明人： Maximilian Fleischer ,  Hans Meixner

IPC分类号： G01N3112

CPC分类号： G01N27/12 ,  G01N33/0031

摘要： A gas sensor array for detecting individual gas constituents in a gas sensor, said array being composed of a carrier member of a non-conductive substrate having a plurality of individual sensor elements formed by semiconductor oxides being applied thereon in a planar arrangement and the array is provided with contact electrode arrangements for measuring electrical conductivity, with a heating arrangement for heating a predetermined operating temperature and with protective sheaths for protecting the arrangement against external influences along with a fastening base so that the individual operating temperatures allocated to the various sensors and wherein the differences between respective sensor signals are formed for detecting the individual gas constituents, with these differences being supplied to a processing unit. In a preferred embodiment, at least one part of the individual sensor element is composed of a &bgr;-Ga2O3 thin film.

摘要翻译： 一种用于检测气体传感器中的各种气体成分的气体传感器阵列，所述阵列由非导电基底的载体构件组成，所述非导电基底具有以半导体氧化物形成的多个单独的传感器元件，所述多个传感器元件以平面布置施加在其上， 设置有用于测量导电性的接触电极装置，具有用于加热预定工作温度的加热装置和用于保护装置与保护基座一起保护装置免受外部影响的加热装置，使得分配给各种传感器的各个操作温度，并且其中 形成各个传感器信号之间的差异，用于检测各个气体成分，这些差异被提供给处理单元。 在优选实施例中，单个传感器元件的至少一部分由β-Ga 2 O 3薄膜构成。

公开(公告)号：US6012327A

公开(公告)日：2000-01-11

申请号：US854482

申请日：1997-05-12

申请人： Michael Seth ,  Maximilian Fleischer ,  Hans Meixner

发明人： Michael Seth ,  Maximilian Fleischer ,  Hans Meixner

IPC分类号： G01N27/12 ,  G01N33/00 ,  G01N7/00 ,  G01N27/04

CPC分类号： G01N33/005 ,  G01N27/125

摘要： A gas sensor and method for manufacturing a gas sensor is provided. In order to increase the selectivity and the sensitivity to a gas to be measured, a gas-sensitive gallium oxide layer of a gas sensor is coated with a filter layer that comprises silicon dioxide. In an alternative embodiment, the gallium oxide layer can be coated with a gas-sensitive metal oxide layer made of titanium oxide, aluminum vanadate, tungsten oxide or tantalum oxide.

摘要翻译： 提供一种用于制造气体传感器的气体传感器和方法。 为了提高对待测气体的选择性和灵敏度，气体传感器的气体敏感性氧化镓层被涂覆有包含二氧化硅的过滤层。 在替代实施例中，氧化镓层可以涂覆有由氧化钛，钒酸铝，氧化钨或氧化钽制成的气敏金属氧化物层。

公开(公告)号：US5767388A

公开(公告)日：1998-06-16

申请号：US734131

申请日：1996-10-21

申请人： Maximilian Fleischer ,  Hans Meixner

发明人： Maximilian Fleischer ,  Hans Meixner

IPC分类号： G01N27/12

CPC分类号： G01N27/12

摘要： A sensor has a temperature in a range from 700.degree. to 850.degree. C. for detecting methane, and an oxygen-sensitive semiconducting metal oxide. A method for operating a gas sensor having two electrodes, an oxygen-sensitive semiconducting metal oxide conductively connecting the electrodes to one another, and a heating element, includes heating the metal oxide to a constant temperature in a range from 700.degree. to 850.degree. C., and measuring the resistance, conductivity or relative permeability of the metal oxide.

摘要翻译： 传感器的温度范围为700〜850℃，用于检测甲烷，以及氧敏感半导体金属氧化物。 一种用于操作具有两个电极的气体传感器的方法，将电极彼此导电连接的氧敏感的半导体金属氧化物和加热元件，包括将金属氧化物加热到700℃至850℃的恒定温度 测量金属氧化物的电阻，电导率或相对磁导率。

公开(公告)号：US5635628A

公开(公告)日：1997-06-03

申请号：US635517

申请日：1996-04-22

申请人： Maximilian Fleischer ,  Hans Meixner

发明人： Maximilian Fleischer ,  Hans Meixner

IPC分类号： G01N27/12 ,  G01N27/72 ,  G01N33/00 ,  G01N27/00 ,  G01N31/12

CPC分类号： G01N33/0047 ,  G01N27/123 ,  G01N33/0016

摘要： A method and apparatus for detecting methane in a gas mixture that may contain commonly used solvents including alcohols and acetones is provided which measures a change in electrical resistivity, electrical conductivity or relative permeability caused by the presence of methane gas at a chemically active sensing structure. The apparatus includes two spaced-apart electrodes that are covered with a thin methane-sensitive semi-conductive metal oxide layer. The gas to be tested is heated to a temperature exceeding 740.degree. C. before it contacts the metal oxide layer. Alcohols, acetones and other solvents are oxidized to electrical carbon dioxide and water before they reach the metal oxide layer so that only the less reactive and reducing gas methane reaches the metal oxide layer where it is reduced and increases the conductivity of the metal oxide layer as measured between the two spaced-apart electrodes with an appropriate electrical meter instrument.

摘要翻译： 提供了一种用于检测气体混合物中甲烷的方法和装置，其可以包含常用的溶剂，包括醇和丙酮，其测量由化学活性感测结构处的甲烷气体存在引起的电阻率，导电性或相对渗透率的变化。 该装置包括被薄的甲烷敏感的半导体金属氧化物层覆盖的两个间隔开的电极。 将待测试的气体在与金属氧化物层接触之前被加热至超过740℃的温度。 醇，丙酮和其他溶剂在它们到达金属氧化物层之前被氧化成电二氧化碳和水，使得只有较少的反应性和还原性气体甲烷到达其中被还原的金属氧化物层，并且将金属氧化物层的导电性提高为 在两个间隔开的电极之间用适当的电表仪器测量。

公开(公告)号：US07085033B2

公开(公告)日：2006-08-01

申请号：US10497306

申请日：2002-09-05

申请人： Christoph Brabec ,  Hans Meixner

发明人： Christoph Brabec ,  Hans Meixner

IPC分类号： G02F1/153

CPC分类号： G02F1/163 ,  G02F1/153 ,  G02F2201/58

摘要： The invention relates to an intelligent color system that recognizes the ambient color and adapts its color accordingly according to the chameleon effect. The inventive system is obtained by combining an electrochromic color system with a semi-transparent array of photodetectors, for example combinations of individual pixels that are sensitive for the different colors (red, green blue), said array being superimposed on the electrochromic color system.

摘要翻译： 本发明涉及一种识别环境颜色并根据变色龙效应适应其颜色的智能彩色系统。 通过将电致变色系统与光电检测器的半透明阵列组合，例如对不同颜色（红色，绿色蓝色）敏感的各个像素的组合，将所述阵列叠加在电致变色系统上来获得本发明的系统。