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21.发明授权Ceramides, process for their preparation and their applications in the cosmetic and dermopharmaceutical fields 失效神经酰胺，其制备方法及其在化妆品和皮肤药物领域的应用
公开(公告)号：US5618523A
公开(公告)日：1997-04-08
申请号：US384434
申请日：1995-02-02
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/66 , A61K8/68 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/97 , A61K8/99 , A61K9/127 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , C07C231/00 , C07C231/02 , C07C233/18 , C07C233/20 , A61K7/00 , A61K7/07
CPC分类号： C07C233/20 , A61K8/14 , A61K8/68 , A61K9/1272 , A61Q19/00 , A61Q5/00 , B82Y5/00 , A61Q1/06 , A61Q1/10 , A61Q5/02 , A61Q5/06 , Y10S514/846 , Y10S514/847
摘要： The invention relates to ceramides of formula: ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical; R.sub.2 denotes a C.sub.11 -C.sub.19 hydrocarbon radical, which is linear and carries one or more ethylenic unsaturations, and in particular one or two, or a mixture of C.sub.11 -C.sub.19 hydrocarbon radicals, which are linear, saturated or carry one or more ethylenic unsaturations, and in particular one or two, in which the proportion of saturated radicals cannot exceed 35%, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers in the erythro:threo proportions of 85:15 to 60:40.The invention also relates to the process for preparing the compounds as well as their applications in the cosmetic and dermopharmaceutical fields.
摘要翻译： 本发明涉及下式的神经酰胺：其中R1表示C11至C21烷基或烯基; R2表示C11-C19烃基，其是线性的并带有一个或多个烯属不饱和基团，特别是线性，饱和或携带一个或多个烯属不饱和基团的一个或两个或C 11 -C 19烃基的混合物， 特别是一个或两个，其中饱和自由基的比例不能超过35％，这些化合物是赤式和苏非非对映异构体的外消旋混合物的形式，其红：苏比例为85:15至60:40。 本发明还涉及制备化合物的方法及其在化妆品和皮肤药物领域中的应用。
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22.发明授权Ceramides, process for their preparation and their applications in the cosmetic and dermopharmaceutical fields 失效神经酰胺，其制备方法及其在化妆品和皮肤药物领域的应用
公开(公告)号：US5773611A
公开(公告)日：1998-06-30
申请号：US811596
申请日：1997-02-26
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/66 , A61K8/68 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/97 , A61K8/99 , A61K9/127 , A61Q1/00 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , C07C231/00 , C07C231/02 , C07C233/18 , C07C233/20 , A61K7/00 , A61K7/48
CPC分类号： C07C233/20 , A61K8/14 , A61K8/68 , A61K9/1272 , A61Q19/00 , A61Q5/00 , B82Y5/00 , A61Q1/06 , A61Q1/10 , A61Q5/02 , A61Q5/06 , Y10S514/846 , Y10S514/847
摘要： The invention relates to ceramides of formula: ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical; R.sub.2 denotes a C.sub.11 -C.sub.19 hydrocarbon radical, which is linear and carries one or more ethylenic unsaturations, and in particular one or two, or a mixture of C.sub.11 -C.sub.19 hydrocarbon radicals, which are linear, saturated or carry one or more ethylenic unsaturations, and in particular one or two, in which the proportion of saturated radicals cannot exceed 35%, these compounds being in the form of a racemic mixture of the erythro and threo diastereoisomers in the erythro:threo proportions of 85:15 to 60:40. The invention also relates to the process for preparing the compounds as well as their applications in the cosmetic and dermopharmaceutical fields.
摘要翻译： 本发明涉及下式的神经酰胺：其中R1表示C11至C21烷基或烯基; R2表示C11-C19烃基，其是线性的并带有一个或多个烯属不饱和基团，特别是线性，饱和或携带一个或多个烯属不饱和基团的一个或两个或C 11 -C 19烃基的混合物， 特别是一个或两个，其中饱和自由基的比例不能超过35％，这些化合物是赤式和苏非非对映异构体的外消旋混合物的形式，其红：苏比例为85:15至60:40。 本发明还涉及制备化合物的方法及其在化妆品和皮肤药物领域中的应用。
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