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30 条记录 (耗时 0.047 秒)

    N.sup.G -monomethyl-L-arginine hydrochloride derivatives and their use in the treatment of septic shock
    22.
    发明授权
    N.sup.G -monomethyl-L-arginine hydrochloride derivatives and their use in the treatment of septic shock 失效
    NG-单甲基-L-精氨酸盐酸盐衍生物及其在治疗败血性休克中的应用

    公开(公告)号：US5767312A

    公开(公告)日：1998-06-16

    申请号：US862468

    申请日：1997-05-23

    申请人： Harold Francis Hodson

    发明人： Harold Francis Hodson

    IPC分类号： C07C279/14 ,  C07C241/00

    CPC分类号： C07C279/14

    摘要： Crystalline N.sup.G -monomethyl-L-arginine hydrochloride is disclosed. At least three distinguishable isomorphic forms are present. The solid salt can be made by dissolving N.sup.G -monomethyl-L-arginine in hydrochloric acid and crystallising out N.sup.G -monomethyl-L-arginine hydrochloride. The crystallising step requires several months at low temperature. However, the process can be facilitated by seeding with crystals of N.sup.G -monomethyl-L-arginine hydrochloride. Alternatively, crystalline N.sup.G -monomethyl-L-arginine hydrochloride can be prepared by dissolving a salt of N.sup.G -monomethyl-L-arginine other than the hydrochloride salt with hydrochloric acid and removing the original salt forming ion by crystallising out the hydrochloride salt.

    摘要翻译： 公开了结晶NG-单甲基-L-精氨酸盐酸盐。 存在至少三种可区别的同构形式。 固体盐可以通过将NG-单甲基-L-精氨酸溶解在盐酸中并结晶出NG-单甲基-L-精氨酸盐酸盐。 结晶步骤在低温下需要几个月。 然而，通过用NG-单甲基-L-精氨酸盐酸盐的晶体接种可以促进该方法。 或者，可以通过将除盐酸盐以外的NG-单甲基-L-精氨酸的盐与盐酸溶解并通过使盐酸盐结晶除去原来的形成盐的方法来制备结晶NG-单甲基-L-精氨酸盐酸盐。

    Cyclic sulphur compounds
    24.
    发明授权
    Cyclic sulphur compounds 失效
    环状硫化合物

    公开(公告)号：US4012499A

    公开(公告)日：1977-03-15

    申请号：US586426

    申请日：1975-06-12

    申请人： Harold Francis Hodson ,  John Frederick Batchelor

    发明人： Harold Francis Hodson ,  John Frederick Batchelor

    IPC分类号： C07C317/44 ,  C07C323/62 ,  A61K9/14 ,  A61K31/41

    CPC分类号： C07C317/44 ,  C07C323/62 ,  Y10S514/826

    摘要： Certain tricyclic thioxanthone-10,10-dioxide compounds each of which is substituted in the 1-,2-,3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-,6-,7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.

    摘要翻译： 某些三环噻吨酮-10,10-二氧化物化合物，其各自在1-，2-，3-或4-位被羧基或（5-四唑基）基团取代，并且其各自任选在5- ，6-或7-位，由第二个羧基或（5-四唑基）基团或选自氰基，卤素，硝基，烷基，烷氧基，酰基，氨基，酰氨基，硫代烷基，烷基亚磺酰基和烷基磺酰基的取代基 作为盐和任选取代的羧基取代的化合物的酯和酰胺和四唑基取代的化合物的烷基衍生物可用于缓解或预防过敏性疾病。

    Serotonin antagonists
    25.
    发明授权
    Serotonin antagonists 失效
    丝氨酸蛋白酶拮抗剂

    公开(公告)号：US3987158A

    公开(公告)日：1976-10-19

    申请号：US437738

    申请日：1974-01-29

    申请人： Harold Francis Hodson

    发明人： Harold Francis Hodson

    IPC分类号： C07D333/16 ,  A61K29/00 ,  A61K31/155 ,  A61K31/38

    CPC分类号： C07D333/16

    摘要： A compound of the formula ##EQU1## or an acid addition salt thereof wherein R.sup.1 and R.sup.2 are the same or different and each is a phenyl or thien-2-yl group optionally substituted in one or more positions by a substituent selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, phenyl, phenoxy, phenyl-(lower-alkyl) and phenyl-(lower-alkoxy), each of the said phenyl, phenoxy, phenyl-(lower-alkyl) and phenyl-(lower-alkoxy) substituent groups being optionally substituted in one or more positions by a member selected from the class consisting of halogen, lower alkyl, lower alkoxy, hydroxy, and lower alkylthio;A.sup.1 is a divalent straight or branched alkylene group containing from two to six carbon atoms and one or two divalent atoms which are each an oxygen or sulphur atom, provided that there are at least two carbon atoms between the divalent atom and the --NH-- group and between the two divalent atoms; andA.sup.2 is the methylene group --CH.sub.2 --.

    Ng-monomethyl-l-argine hydrochloride derivatives and their use in the treatment of septic shock
    27.
    发明授权
    Ng-monomethyl-l-argine hydrochloride derivatives and their use in the treatment of septic shock 失效
    Ng-单甲基-1-谷氨酸盐酸衍生物及其在治疗败血性休克中的应用

    公开(公告)号：US5856565A

    公开(公告)日：1999-01-05

    申请号：US459614

    申请日：1995-06-02

    申请人： Harold Francis Hodson

    发明人： Harold Francis Hodson

    IPC分类号： C07C279/14 ,  C07C241/00

    CPC分类号： C07C279/14

    摘要： A process for preparing crystalline N.sup.G -monomethyl-L-arginine hydrochloride is disclosed. The process comprises dissolving N.sup.G -monomethyl-L-arginine in hydrochloric acid and crystallising out N.sup.G -monomethyl-L-arginine hydrochloride. The crystallising step requires several months at low temperature. However, the process can be facilitated by seeding with crystals of N.sup.G -monomethyl-L-arginine hydrochloride. Alternatively, crystalline N.sup.G -monomethyl-L-arginine hydrochloride can be prepared by dissolving a salt of N.sup.G -monomethyl-L-arginine other than the hydrochloride salt with hydrochloric acid and removing the original salt forming ion by crystallising out the hydrochloride salt.

    摘要翻译： 公开了制备结晶NG-单甲基-L-精氨酸盐酸盐的方法。 该方法包括将NG-单甲基-L-精氨酸溶解在盐酸中并结晶出NG-单甲基-L-精氨酸盐酸盐。 结晶步骤在低温下需要几个月。 然而，通过用NG-单甲基-L-精氨酸盐酸盐的晶体接种可以促进该方法。 或者，可以通过将除盐酸盐以外的NG-单甲基-L-精氨酸的盐与盐酸溶解并通过使盐酸盐结晶除去原来的形成盐的方法来制备结晶NG-单甲基-L-精氨酸盐酸盐。

    Cyclic sulphur compounds
    29.
    发明授权
    Cyclic sulphur compounds 失效
    环状硫化合物

    公开(公告)号：US4025635A

    公开(公告)日：1977-05-24

    申请号：US394424

    申请日：1973-09-05

    申请人： Harold Francis Hodson ,  John Frederick Batchelor

    发明人： Harold Francis Hodson ,  John Frederick Batchelor

    IPC分类号： C07C317/44 ,  C07C323/62 ,  C07D257/04 ,  A61K31/41

    CPC分类号： C07C317/44 ,  C07C323/62

    摘要： Certain tricyclic sulphone compounds each of which is substituted in the 1-,2-,3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-,6-,7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.

    摘要翻译： 某些三环砜化合物各自通过羧基或（5-四唑基）基团在1-，2-，3-或4-位上被取代，并且它们各自在5-，6-，7- 或8-位，由第二个羧基或（5-四唑基）基团或选自氰基，卤素，硝基，烷基，烷氧基，酰基，氨基，酰氨基，硫代烷基，烷基亚磺酰基和烷基磺酰基的取代基取代， 羧基取代的化合物的酯和酰胺和四唑基取代的化合物的烷基衍生物可用于缓解或预防过敏性疾病。

    Cyclic carbonyl compounds
    30.
    发明授权
    Cyclic carbonyl compounds 失效
    环状羰基化合物

    公开(公告)号：US3939276A

    公开(公告)日：1976-02-17

    申请号：US338415

    申请日：1973-03-06

    申请人： Harold Francis Hodson ,  John Frederick Batchelor

    发明人： Harold Francis Hodson ,  John Frederick Batchelor

    IPC分类号： C07C51/41 ,  C07C65/36 ,  C07C65/40 ,  C07C66/02 ,  A61K31/19

    CPC分类号： C07C66/02 ,  C07C51/412 ,  C07C65/36 ,  C07C65/40 ,  Y10S514/826 ,  Y10S514/849

    摘要： Certain fluorenone and anthraquinone compounds, each of which is 2-substituted by a carboxyl group or a salt, ester or optionally substituted amide thereof and each of which is optionally substituted in the 5,6-,7- or 8- position, by a second carboxyl group, salt, ester or optionally substituted amide thereof, the substitutent in the 5,6-7- or 8- position of the fluorenone compounds, also being selected from cyano, halogen, nitro, alkyl, alkoxy and acyl, are useful for the relief or prophylaxis of allergic conditions.

    摘要翻译： 某些芴酮和蒽醌化合物，其各自被羧基或其盐，酯或任选取代的酰胺取代，并且其各自任选在5,6-，7-或8-位置被一个 第二个羧基，盐，酯或任选取代的酰胺，也可以选自氰基，卤素，硝基，烷基，烷氧基和酰基的芴酮化合物的5,6,7-或8-位的取代基是有用的 用于缓解或预防过敏症状。