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公开(公告)号：US20180346415A1
公开(公告)日：2018-12-06
申请号：US15779132
申请日：2016-11-30
Inventor： Laurence HURLEY , Vijay GOKHALE , HyunJin KANG , Kui WU
IPC: C07C275/54 , C07D401/12 , C07D239/52 , C07D239/34 , C07D403/04 , C07D241/18 , C07D295/088 , C07D219/08 , A61P35/00
CPC classification number: C07C275/54 , A61K31/17 , A61K31/4402 , A61K31/4995 , A61K31/505 , A61K31/5377 , A61P35/00 , C07D219/08 , C07D239/34 , C07D239/52 , C07D241/18 , C07D295/088 , C07D401/12 , C07D403/04
Abstract: The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
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公开(公告)号：US20180303807A1
公开(公告)日：2018-10-25
申请号：US15765140
申请日：2016-10-01
Applicant: John KATZENELLENBOGEN , Jatinder JOSAN , DUKE UNIVERSITY , BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY , VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY
Inventor： John A. Katzenellenbogen , Jatinder Josan , John Norris , Donald P. McDonnell
IPC: A61K31/4375 , A61P35/00 , A61K31/4365
CPC classification number: A61K31/4375 , A61K31/4365 , A61P35/00 , C07D219/08 , C07D221/02 , C07D311/78 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/10 , C07D471/04 , C07D471/14 , C07D495/14
Abstract: Described are compounds that inhibit androgen receptor action, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.
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公开(公告)号：US20180127456A1
公开(公告)日：2018-05-10
申请号：US15850028
申请日：2017-12-21
Inventor： Jack Coleman , Elazar Rabbani , Jannis Stavrianopoulos , Praveen Pande
IPC: C07H21/00 , G01N33/58 , C12Q1/6818 , C09B11/24 , G01N33/533 , C12Q1/68 , C09B57/02 , C07D219/08 , C07D405/14 , C09B11/08 , C07H21/04 , C07D491/22 , C09B11/00
CPC classification number: C07H21/00 , C07D219/08 , C07D405/14 , C07D491/22 , C07H21/04 , C09B11/00 , C09B11/08 , C09B11/24 , C09B57/02 , C12Q1/68 , C12Q1/6818 , G01N33/533 , G01N33/582
Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.
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公开(公告)号：US20180127455A1
公开(公告)日：2018-05-10
申请号：US15849997
申请日：2017-12-21
Inventor： Jack Coleman , Elazar Rabbani , Jannis Stavrianopoulos , Praveen Pande
IPC: C07H21/00 , G01N33/58 , C12Q1/6818 , C09B11/24 , G01N33/533 , C12Q1/68 , C09B57/02 , C07D219/08 , C07D405/14 , C09B11/08 , C07H21/04 , C07D491/22 , C09B11/00
CPC classification number: C07H21/00 , C07D219/08 , C07D405/14 , C07D491/22 , C07H21/04 , C09B11/00 , C09B11/08 , C09B11/24 , C09B57/02 , C12Q1/68 , C12Q1/6818 , G01N33/533 , G01N33/582
Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.
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公开(公告)号：US09893295B2
公开(公告)日：2018-02-13
申请号：US14645746
申请日：2015-03-12
Applicant: SAMSUNG DISPLAY CO., LTD.
Inventor： Jongwoo Kim , Youngkook Kim , Jino Lim , Hyungseok Jang , Seokhwan Hwang
IPC: H01L51/00 , C07D219/08 , C07D401/12 , C07D219/02 , H01L51/50
CPC classification number: H01L51/0067 , C07D219/02 , C07D219/08 , C07D401/12 , H01L51/0003 , H01L51/0052 , H01L51/0058 , H01L51/006 , H01L51/0061 , H01L51/0072 , H01L51/5056
Abstract: Provided are a compound represented by Formula 1 and an organic light-emitting device including the same: wherein substituents of Formula 1 are understood by referring to the description provided in the detailed description.
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Patent Agency Ranking
6.发明申请HINDERED PHENOL COMPOUND, PREPARATION THEREOF AND USE THEREOF AS AN ANTIOXIDANT 有权苯酚化合物，其制备方法及其作为抗氧化剂的用途公开(公告)号：US20150353858A1
公开(公告)日：2015-12-10
申请号：US14296763
申请日：2014-06-05
Applicant: CHINA PETROLEUM & CHEMICAL CORPORATION , RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPEC
Inventor： Shuo SU , Jun LONG , Qinghua DUAN , Han ZHOU , Zhiqiang WU , Xinhua LI , Yi ZHAO , Xiaoguang ZHAO
IPC: C10M135/36 , C07D513/04 , C07D279/20 , C07C319/14 , C07D219/08
CPC classification number: C10M135/36 , C07C313/04 , C07C319/14 , C07C323/20 , C07C323/25 , C07C323/32 , C07C323/52 , C07C323/60 , C07D219/08 , C07D279/20 , C07D513/04 , C10M129/10 , C10M135/12 , C10M135/28 , C10M2203/1025 , C10M2207/026 , C10M2207/289 , C10M2215/064 , C10M2215/065 , C10M2219/06 , C10M2219/086 , C10M2219/087 , C10M2219/104 , C10M2219/108 , C10N2230/02 , C10N2230/04 , C10N2230/10 , C10N2230/12
Abstract: This invention relates to a novel hindered phenol compound of Formula (I) (wherein the groups R and R′ are as defined in the specification), preparation thereof and use thereof as an antioxidant. By using the hindered phenol compound of this invention as an antioxidant, it is possible to produce a lubricant oil composition exhibiting excellent oxidation resistance at elevated temperatures.
Abstract translation: 本发明涉及式（I）的新型受阻酚化合物（其中基团R和R'如说明书中所定义），其制备及其作为抗氧化剂的用途。 通过使用本发明的受阻酚化合物作为抗氧化剂，可以制备在高温下表现出优异的耐氧化性的润滑油组合物。
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公开(公告)号：US09156986B2
公开(公告)日：2015-10-13
申请号：US13065101
申请日：2011-03-14
Applicant: Jack Coleman , Elazar Rabbani , Jannis Stavrianopoulos , Praveen Pande
Inventor： Jack Coleman , Elazar Rabbani , Jannis Stavrianopoulos , Praveen Pande
IPC: C07D221/18 , C09B11/24 , C07D219/08 , C07D491/22 , C07H21/00 , C07H21/04 , C09B11/08 , C07D405/14 , C09B11/00 , C09B57/02 , G01N33/533 , C12P19/34 , C07H19/04 , C12Q1/68
CPC classification number: C07H21/00 , C07D219/08 , C07D405/14 , C07D491/22 , C07H21/04 , C09B11/00 , C09B11/08 , C09B11/24 , C09B57/02 , C12Q1/68 , C12Q1/6818 , G01N33/533 , G01N33/582
Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.
Abstract translation: 提供了包含由连接基共价连接的两个DNA超分子结合分子的化合物。 还提供了多信号标记试剂，其包含（i）核苷酸或核苷酸类似物的寡聚物; （ii）非共价结合寡聚体的DNA超分子结合分子; 和（iii）与低聚物共价结合的第一结合对的第一反应性基团或第一配偶体。 另外提供了生产多信号标记试剂的方法。
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公开(公告)号：US20140148451A1
公开(公告)日：2014-05-29
申请号：US14116650
申请日：2012-05-09
Applicant: Jeffrey Paul MacKeigan , Katie Renee Martin , Megan Lynne Goodall , Stephen Gately , Tong Wang
Inventor： Jeffrey Paul MacKeigan , Katie Renee Martin , Megan Lynne Goodall , Stephen Gately , Tong Wang
IPC: C07D219/10 , C07D219/12 , C07D471/04 , C07D401/12
CPC classification number: C07D219/10 , C07D219/08 , C07D219/12 , C07D221/16 , C07D401/12 , C07D471/04
Abstract: The present invention relates to compounds of formulas III and V that are useful as pharmaceutical agents, particularly as autophagy inhibitors.
Abstract translation: 本发明涉及可用作药剂，特别是自噬抑制剂的式III和V化合物。
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公开(公告)号：US20100061928A1
公开(公告)日：2010-03-11
申请号：US12375044
申请日：2007-07-27
Applicant: Jean-Claude Madelmont , Jean-Michel Chezal , Nicole Moins , Jean-Claude Teulade , Olivier Chavignon
Inventor： Jean-Claude Madelmont , Jean-Michel Chezal , Nicole Moins , Jean-Claude Teulade , Olivier Chavignon
IPC: A61K51/04 , C07C233/77 , C07D213/56 , C07D471/04 , C07D215/48 , C07D217/26 , C07D241/44 , C07D219/06 , C07D219/04 , A61P35/00
CPC classification number: C07D471/04 , C07B2200/05 , C07C233/62 , C07D209/42 , C07D213/81 , C07D213/82 , C07D215/48 , C07D215/54 , C07D215/56 , C07D217/26 , C07D219/04 , C07D219/06 , C07D219/08 , C07D235/24 , C07D241/44 , C07D241/46 , C07D333/68
Abstract: The present invention relates to the use of a compound of formula (I): in which R1 represents a radionuclide, Ar represents an aromatic nucleus, m is an integer varying from 2 to 4, R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group, a (C1-C6)alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.
Abstract translation: 本发明涉及式（I）化合物的用途：其中R1表示放射性核素，Ar表示芳香核，m表示2至4的整数，R2和R3彼此独立地表示 氢原子，（C1-C6）烷基，（C1-C6）烯基或选自苯基，苄基，咪唑基，吡啶基，嘧啶基，吡嗪基，吲哚基，吲唑基，呋喃基和噻吩基的芳基， 与药学上可接受的酸的加成盐，用于制备用于诊断和/或治疗黑素瘤的放射性药物组合物。
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公开(公告)号：US07105531B2
公开(公告)日：2006-09-12
申请号：US10618044
申请日：2003-07-10
Applicant: Dan M. Berger , Minu D. Dutia , Frenel F. DeMorin , Diane H. Boschelli , Dennis W. Powell , Hwei-Ru Tsou , Allan Wissner , Nan Zhang , Fei Ye , Biqi Wu
Inventor： Dan M. Berger , Minu D. Dutia , Frenel F. DeMorin , Diane H. Boschelli , Dennis W. Powell , Hwei-Ru Tsou , Allan Wissner , Nan Zhang , Fei Ye , Biqi Wu
IPC: A61K31/44 , C07D471/04
CPC classification number: C07D401/12 , C07D215/48 , C07D215/54 , C07D215/56 , C07D219/04 , C07D219/06 , C07D219/08 , C07D221/08 , C07D333/66 , C07D333/70 , C07D401/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07F7/0812
Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
Abstract translation: 本发明提供式1化合物，其具有可用作蛋白酪氨酸激酶抑制剂的结构，并且是抗增殖剂。
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