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公开(公告)号：US08324222B2
公开(公告)日：2012-12-04
申请号：US12086784
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： C07D491/04 , A61K31/519 , A61P9/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新的循环取代的呋喃嘧啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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公开(公告)号：US08183246B2
公开(公告)日：2012-05-22
申请号：US12086783
申请日：2006-12-08
申请人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
发明人： Thomas Lampe , Eva-Maria Becker , Raimund Kast , Hartmut Beck , Mario Jeske , Joachim Schuhmacher , Friederike Stoll , Martina Klein , Metin Akbaba , Andreas Knorr , Johannes-Peter Stasch , Lars Bärfacker , Alexander Hillisch , Gunter Karig , Mark Meininghaus , Karl-Heinz Schlemmer , Rudolf Schohe-Loop
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00
CPC分类号： C07D491/04
摘要： The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
摘要翻译： 本申请涉及新颖的非循环取代的呋喃嘧啶衍生物，其生产方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于 治疗和/或预防心血管疾病。
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公开(公告)号：US06462068B1
公开(公告)日：2002-10-08
申请号：US09644305
申请日：2000-08-23
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K31416
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的杂环基甲基取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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公开(公告)号：US06410740B1
公开(公告)日：2002-06-25
申请号：US09645834
申请日：2000-08-25
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： C07D41304
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的杂环基甲基取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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25.发明授权Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems 失效使用缩合（杂芳基取代的）1-苄基-3-吡唑衍生物治疗心血管和中枢神经系统的特殊疾病公开(公告)号：US06180656B2
公开(公告)日：2001-01-30
申请号：US09284032
申请日：1999-04-06
申请人： Chantal F{umlaut over (u)}rstner , Alexander Straub , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim H{umlaut over (u)}tter , Klaus Dembowsky
发明人： Chantal F{umlaut over (u)}rstner , Alexander Straub , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim H{umlaut over (u)}tter , Klaus Dembowsky
IPC分类号： A61K31415
CPC分类号： C07D405/04 , A61K31/416
摘要： The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) in which R1 to R4 have the meaning indicated in the description, as medicaments, and to new active compounds, in particular to their use as vasodilators, if appropriate in combination with organic nitrates and NO donors and if appropriate in combination with compounds which inhibit the degradation of cGMP.
摘要翻译： 本发明涉及1-苄基-3-（取代的杂芳基） - 引入的吡唑衍生物的新用途，其中一些是已知的通式（I），其中R 1至R 4具有说明书中指出的含义， 作为药物，以及新的活性化合物，特别是它们用作血管舒张剂，如果适合与有机硝酸盐和NO供体结合使用，并且适当时与抑制cGMP降解的化合物组合使用。
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26.发明授权Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases 失效杂环甲基取代的吡唑衍生物及其用于治疗心血管疾病的用途
公开(公告)号：US6166027A
公开(公告)日：2000-12-26
申请号：US284172
申请日：1999-04-09
申请人： Alexander Straub , Chantal Furstner , Ulrich Niewohner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hutter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Furstner , Ulrich Niewohner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hutter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K31/416 , A61K31/422 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/501 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/28 , C07D20060101 , C07D263/32 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , A61K31/506
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译： PCT No.PCT / EP97 / 05432 Sec。 371日期1999年4月9日第 102（e）日期1999年4月9日PCT 1997年10月2日PCT公布。 第WO98 / 16507号公报 日期：1998年4月23日本发明涉及新的杂环基甲基取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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27.发明授权Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases 失效用于治疗心脏循环疾病的取代的吡唑衍生物公开(公告)号：US06451805B1
公开(公告)日：2002-09-17
申请号：US09297121
申请日：1999-04-23
申请人： Alexander Straub , Chantal Fürstner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky
发明人： Alexander Straub , Chantal Fürstner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky
IPC分类号： A61K31506
CPC分类号： C07D405/04 , C07D471/04 , C07D487/04
摘要： The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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公开(公告)号：US06387940B1
公开(公告)日：2002-05-14
申请号：US09644179
申请日：2000-08-23
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K314155
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
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公开(公告)号：US07173037B2
公开(公告)日：2007-02-06
申请号：US10513869
申请日：2003-04-25
申请人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
发明人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
IPC分类号： C07D471/04 , A61K31/506 , C07D231/38
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
摘要翻译： 本发明涉及刺激可溶性鸟苷酸环化酶，其制备及其作为药物的用途，特别是作为用于治疗心血管疾病和/或性功能障碍的药物的化合物。
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30.发明授权Derivatives of 2-(1-benzyl-1H-pyrazolo(3,4-B)pyridine-3-yl)-5(-4-pyridinyl)l-4-pyrimidinamines and the use thereof as quanylate cyclase stimulators 有权2-（1-苄基-1H-吡唑并（3,4-B）吡啶-3-基）-5（-4-吡啶基）-1- [4-嘧啶胺]的衍生物及其作为苯甲酸酯环化酶刺激剂的用途公开(公告)号：US07135474B2
公开(公告)日：2006-11-14
申请号：US10514909
申请日：2003-05-05
IPC分类号： C07D471/04 , A61K31/505 , C07D231/38
CPC分类号： C07D471/04
摘要： This application relates to compounds of the formula (I) in which R1 is chlorine, cyano, trifluoromethyl or methoxy and R2 is hydrogen or flurorine; or R1 and R2 are both fluorine; and to pharmaceutically acceptable salts of these materials. Pharmaceutical compositions containing these materials, and methods of using them in treatment of hypertension and sexual dysfunction are also disclosed and claimed.
摘要翻译： 本申请涉及式（I）化合物，其中R 1是氯，氰基，三氟甲基或甲氧基，R 2是氢或氟磺酰; 或R 1和R 2均为氟; 以及这些材料的药学上可接受的盐。 还公开并要求保护含有这些材料的药物组合物和使用它们治疗高血压和性功能障碍的方法。
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