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32 条记录 (耗时 0.039 秒)

    Method of separating alpha-L-aspartyl-L-phenylalanine methyl ester through crystallization
    21.
    发明授权
    Method of separating alpha-L-aspartyl-L-phenylalanine methyl ester through crystallization 失效
    通过结晶分离α-L-天冬氨酰-L-苯丙氨酸甲酯的方法

    公开(公告)号：US4994605A

    公开(公告)日：1991-02-19

    申请号：US342894

    申请日：1989-04-25

    申请人： Shinichi Kishimoto ,  Katsumi Sugiyama

    发明人： Shinichi Kishimoto ,  Katsumi Sugiyama

    IPC分类号： C07C231/00 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075

    CPC分类号： C07K5/0613

    摘要： A method for crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester (APM) is disclosed. The APM is crystallized from a C.sub.1 -C.sub.3 -alcohol/water solution (30-80:70-20 (v/v)). The ester crystallized by (i) concentrating the solution, (ii) cooling the solution, (iii) adjusting the water:alcohol ratio, or (iv) a combination thereof.

    摘要翻译： 公开了一种结晶α-L-天冬氨酰-L-苯丙氨酸甲酯（APM）的方法。 APM从C1-C3-醇/水溶液（30-80:70-20（v / v））中结晶。 所述酯通过（i）浓缩溶液，（ii）冷却溶液，（iii）调节水：醇比例，或（iv）其组合来结晶。

    Method for reductive elimination of protecting groups
    24.
    发明授权
    Method for reductive elimination of protecting groups 失效
    还原消除保护基团的方法

    公开(公告)号：US4564471A

    公开(公告)日：1986-01-14

    申请号：US188107

    申请日：1980-09-17

    申请人： Katsumi Sugiyama ,  Hideo Takeda ,  Hiroko Sato ,  Yuji Nonaka ,  Kiyotaka Oyama ,  Masashige Kubo

    发明人： Katsumi Sugiyama ,  Hideo Takeda ,  Hiroko Sato ,  Yuji Nonaka ,  Kiyotaka Oyama ,  Masashige Kubo

    IPC分类号： C07B31/00 ,  C07B51/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/16 ,  C07C227/18 ,  C07C227/20 ,  C07C231/00 ,  C07K1/06 ,  C07K1/12 ,  C07K5/075 ,  C07C101/02

    CPC分类号： C07K1/12 ,  C07K5/0613 ,  Y02P20/55

    摘要： The invention provides a novel and efficient method for the elimination of protecting groups, e.g. benzyloxycarbonyl group, from a protected amino acid, peptide or derivative thereof having at least one functional group protected by a protecting group, e.g. a lower alkyl ester of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine by catalytic hydrogen reduction to produce free amino acid, peptide or derivative thereof. In contrast to the conventional procedures in which the reaction is carried out in a solvent dissolving both the starting compound and the product compound or a solvent dissolving the starting compound but not dissolving the product compound, the inventive method utilizes a binary two-phase reaction medium composed of water and an organic solvent not freely miscible with water such as toluene. The reaction takes place in the organic phase containing the starting compound dissolved and the catalyst dispersed therein whereas the reaction product which is water-soluble is smoothly and successively transferred into the aqueous phase so that advantages are obtained in the unexpectedly high yield of the product as well as in the easiness of handling the reaction mixture after completion of the reaction.

    摘要翻译： 本发明提供了一种用于消除保护基团的新型和有效的方法，例如， 苄氧羰基，被保护的氨基酸，具有至少一个被保护基保护的官能团的肽或衍生物。 N-苄氧羰基-α-L-天冬氨酰基-L-苯丙氨酸的低级烷基酯通过催化氢还原反应产生游离氨基酸，肽或其衍生物。 与在溶解起始化合物和产物化合物的溶剂或溶解起始化合物但不溶解产物化合物的溶剂中进行反应的常规方法相反，本发明的方法利用二元二相反应介质 由水和不能与水如甲苯自由混溶的有机溶剂组成。 反应发生在含有溶解的起始化合物和分散在其中的催化剂的有机相中，而水溶性的反应产物顺利地依次转移到水相中，从而获得了产品出乎意料的高产率的优点， 以及在反应完成后容易处理反应混合物。

    Chalcone compound
    26.
    发明授权
    Chalcone compound 失效
    查耳酮化合物

    公开(公告)号：US07361774B2

    公开(公告)日：2008-04-22

    申请号：US10529859

    申请日：2003-09-29

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： C07D311/82 ,  C07D311/00 ,  A01N43/16

    CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/10 ,  C07D311/58

    摘要： The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.

    摘要翻译： 本发明涉及由下列通式表示的查尔酮化合物：其中R 1和R 2分别与它们所连接的碳原子一起取代， 形成羟基二甲基己烷环，或其中R 1是羟基，R 2是异己烯基，其衍生物或其盐。 此外，本发明涉及需要神经元保护，抑制一氧化氮（NO）产生，抑制醛糖还原酶或抑制白介素产生的疾病的治疗剂或预防剂，以及用于治疗或预防的食品，饮料或饲料 的上述疾病，其特征在于，每种都包含上述化合物作为有效成分。

    Remedy
    29.
    发明申请
    Remedy 审中-公开
    补救

    公开(公告)号：US20060051316A1

    公开(公告)日：2006-03-09

    申请号：US10537333

    申请日：2003-12-05

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K31/74 ,  A61K31/737 ,  A61K31/727 ,  A61K31/715

    CPC分类号： A61K36/02 ,  A23L33/10 ,  A61K31/216 ,  A61K31/737 ,  A61K31/78

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of bone morphogenetic protein production or promotion of osteogenesis; an agent for enhancement of bone morphogenetic protein production or an agent for promotion of osteogenesis, a food, beverage or feed for enhancement of bone mornhogenetic protein production or promotion of osteogenesis, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of (a) an acidic saccharide, (b) a polyacrylic acid, (c) chlorogenic acid and (d) an oxidation processed product of chlorogenic acid, or an extract derived from algae.

    摘要翻译： 本发明涉及需要增强骨形态发生蛋白产生或促进成骨的疾病的治疗剂或预防剂; 用于增强骨形态发生蛋白质产生的药物或用于促进成骨的药剂，用于增强骨发生蛋白质产生或促进成骨的食品，饮料或饲料，其特征在于，每种药物包含作为有效成分的至少一种选自 由（a）酸性糖，（b）聚丙烯酸，（c）绿原酸和（d）绿原酸的氧化加工产物或源自藻类的提取物组成的组。

    Remedy
    30.
    发明申请
    Remedy 审中-公开
    补救

    公开(公告)号：US20060034949A1

    公开(公告)日：2006-02-16

    申请号：US10524015

    申请日：2003-08-06

    申请人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K36/232

    CPC分类号： A61K36/232 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed for treating or preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancement of glucose uptake into a cell, and an agent for induction of an adipocyte differentiation, each comprising as an effective ingredient a processed product derived from a plant belonging to Umbelliferae.

    摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，用于治疗或预防伴随异常的疾病的胰岛素模拟作用剂，食品，饮料或饲料 一定量的胰岛素或胰岛素反应，用于增强葡萄糖摄入细胞的药剂和用于诱导脂肪细胞分化的药剂，其各自包含衍生自属于伞形属植物的植物的加工产品作为有效成分。