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公开(公告)号：US08486942B2
公开(公告)日：2013-07-16
申请号：US13301642
申请日：2011-11-21
申请人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/5355
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US08383655B2
公开(公告)日：2013-02-26
申请号：US13103970
申请日：2011-05-09
申请人： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/426
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
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公开(公告)号：US20100189687A1
公开(公告)日：2010-07-29
申请号：US12528185
申请日：2008-02-22
申请人： Manoj C. Desai , Allen Y. Hong , Hon Chung Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hon Chung Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/427 , C07D417/12 , C07D417/14 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/541 , A61K31/5377 , A61P31/18 , A61K31/7072 , A61K31/708 , A61K31/7068 , A61K38/21 , A61K39/395
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20090291952A1
公开(公告)日：2009-11-26
申请号：US12306198
申请日：2007-07-06
申请人： Manoj C. Desai , Allen Y. Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/427 , C07D417/12 , C07D413/14 , A61K31/5377 , A61K31/4436 , A61P31/18 , A61P7/00
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US07939553B2
公开(公告)日：2011-05-10
申请号：US11825605
申请日：2007-07-06
申请人： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/426 , C07D277/20
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US08334295B2
公开(公告)日：2012-12-18
申请号：US12215450
申请日：2008-06-26
申请人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
发明人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
IPC分类号： A61K31/505
CPC分类号： A61K31/513 , A61K31/496 , A61K31/536 , A61K31/551 , A61K31/66 , A61K31/7048 , A61K31/7072 , A61K31/708 , A61K39/39558 , A61K45/06 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D401/04 , C07D403/04
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20090181902A1
公开(公告)日：2009-07-16
申请号：US12217496
申请日：2008-07-03
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
IPC分类号： A61K38/05 , C07D417/12 , A61K31/427 , C07D417/14 , A61K31/5377 , A61K31/496 , A61P31/12
CPC分类号： C07D277/28 , C07D417/14
摘要： The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20110076276A1
公开(公告)日：2011-03-31
申请号：US12215450
申请日：2008-06-26
申请人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
发明人： Hongyan Guo , Choung U. Kim , Ill Y. Lee , Michael L. Mitchell , Gerry Rhodes , Jong C. Son , Lianhong Xu
IPC分类号： A61K39/395 , C07D239/24 , A61K31/505 , A61K31/496 , A61K31/536 , A61K31/551 , A61P31/18 , A61K31/7072 , A61K31/7064 , A61K31/7076 , A61K31/66 , A61K38/16
CPC分类号： A61K31/513 , A61K31/496 , A61K31/536 , A61K31/551 , A61K31/66 , A61K31/7048 , A61K31/7072 , A61K31/708 , A61K39/39558 , A61K45/06 , C07D239/54 , C07D239/545 , C07D239/553 , C07D239/60 , C07D401/04 , C07D403/04
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US08987313B2
公开(公告)日：2015-03-24
申请号：US13996188
申请日：2011-12-20
申请人： Manoj C. Desai , Hon Chung Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
发明人： Manoj C. Desai , Hon Chung Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
IPC分类号： A61K31/426 , A61K31/497 , A61K31/445 , A61K31/535 , C07D417/14 , A61K31/427 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04
CPC分类号： C07D417/14 , A61K31/427 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04
摘要： The present application provides for a compound of formula I, or a salt thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供了式I化合物或其盐，含有这些化合物的组合物，包括施用这些化合物的治疗方法以及包括将这些化合物与至少一种另外的治疗剂一起施用的治疗方法。
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公开(公告)号：US20130309197A1
公开(公告)日：2013-11-21
申请号：US13996188
申请日：2011-12-20
申请人： Manoj C. Desai , Hon Chung Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
发明人： Manoj C. Desai , Hon Chung Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
IPC分类号： C07D417/14 , A61K45/06 , A61K31/437 , A61K31/496 , A61K31/5377 , C07D471/04 , A61K31/427 , A61K31/454
CPC分类号： C07D417/14 , A61K31/427 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D471/04
摘要： The present application provides for a compound of formula I, or a salt thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供了式I化合物或其盐，含有这些化合物的组合物，包括施用这些化合物的治疗方法以及包括将这些化合物与至少一种另外的治疗剂一起施用的治疗方法。
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