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公开(公告)号：US20090181902A1
公开(公告)日：2009-07-16
申请号：US12217496
申请日：2008-07-03
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
IPC分类号： A61K38/05 , C07D417/12 , A61K31/427 , C07D417/14 , A61K31/5377 , A61K31/496 , A61P31/12
CPC分类号： C07D277/28 , C07D417/14
摘要： The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US08088770B2
公开(公告)日：2012-01-03
申请号：US12217496
申请日：2008-07-03
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Jianyu Sun , Lianhong Xu
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/437 , A61K31/4402 , A61K31/426 , C07D417/04 , C07D487/04 , C07D277/24
CPC分类号： C07D277/28 , C07D417/14
摘要： The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20120237478A1
公开(公告)日：2012-09-20
申请号：US13301642
申请日：2011-11-21
申请人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/5377 , A61P31/14 , A61K38/57 , A61K39/395 , A61K38/21 , A61K31/7056
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US08486942B2
公开(公告)日：2013-07-16
申请号：US13301642
申请日：2011-11-21
申请人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/5355
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US08759379B2
公开(公告)日：2014-06-24
申请号：US12340419
申请日：2008-12-19
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
IPC分类号： A61K31/341 , A61K31/34 , A61K31/5377 , A61K31/427 , C07D417/12 , C07D417/14 , C07D493/04 , C07D307/20
CPC分类号： A61K31/427 , A61K31/34 , A61K31/341 , A61K31/5377 , C07D277/28 , C07D307/20 , C07D417/12 , C07D417/14 , C07D493/04
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20090175820A1
公开(公告)日：2009-07-09
申请号：US12340419
申请日：2008-12-19
申请人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
发明人： Manoj C. Desai , Hon C. Hui , Hongtao Liu , Lianhong Xu
IPC分类号： A61K38/21 , C07D415/00 , A61K31/5377 , A61K31/427
CPC分类号： A61K31/427 , A61K31/34 , A61K31/341 , A61K31/5377 , C07D277/28 , C07D307/20 , C07D417/12 , C07D417/14 , C07D493/04
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20080207620A1
公开(公告)日：2008-08-28
申请号：US12036124
申请日：2008-02-22
申请人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
发明人： Manoj C. Desai , Allen Y. Hong , Hon C. Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC分类号： A61K31/5375 , C07D277/22 , A61P31/00 , C07D247/00 , A61K31/44 , A61K31/497 , C07D417/02 , A61K31/426
CPC分类号： G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
摘要： The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
摘要翻译： 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20080255214A1
公开(公告)日：2008-10-16
申请号：US11940260
申请日：2007-11-14
申请人： Erik J. Verner , Hon C. Hui
发明人： Erik J. Verner , Hon C. Hui
IPC分类号： A61K31/428 , C07D277/68 , C07D263/58 , A61K31/4184 , A61P35/00 , C07D235/24 , A61K31/423
CPC分类号： A61K31/343 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , A61N5/10 , C07C259/10 , C07C2601/02 , C07D207/12 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , A61K2300/00
摘要： The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译： 本发明涉及可用于治疗丙型肝炎的某些异羟肟酸衍生物。这些化合物也是组蛋白脱乙酰酶的抑制剂，因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。 还公开了制备这些化合物的药物组合物和方法。
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公开(公告)号：US07482466B2
公开(公告)日：2009-01-27
申请号：US11940260
申请日：2007-11-14
申请人： Erik J. Verner , Hon C. Hui
发明人： Erik J. Verner , Hon C. Hui
IPC分类号： C07D277/62 , C07D263/54 , C07D235/04 , A61K31/425
CPC分类号： A61K31/343 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , A61N5/10 , C07C259/10 , C07C2601/02 , C07D207/12 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , A61K2300/00
摘要： The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
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公开(公告)号：US20080255221A1
公开(公告)日：2008-10-16
申请号：US11940273
申请日：2007-11-14
申请人： Erik J. Verner , Hon C. Hui
发明人： Erik J. Verner , Hon C. Hui
IPC分类号： A61K31/4025 , C07C233/81 , A61K31/164 , A61K31/343 , A61P35/00 , C07D307/85 , C07D405/12
CPC分类号： A61K31/343 , A61K31/18 , A61K31/33 , A61K31/34 , A61K31/4015 , A61K31/4415 , A61K41/00 , A61K45/06 , A61N5/10 , C07C259/10 , C07C2601/02 , C07D207/12 , C07D207/327 , C07D207/34 , C07D209/08 , C07D209/18 , C07D209/42 , C07D209/44 , C07D211/46 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/08 , C07D215/18 , C07D215/48 , C07D215/54 , C07D217/04 , C07D217/06 , C07D217/26 , C07D231/56 , C07D235/06 , C07D235/24 , C07D241/52 , C07D249/18 , C07D261/18 , C07D263/58 , C07D277/30 , C07D277/42 , C07D277/56 , C07D277/68 , C07D307/54 , C07D307/68 , C07D307/79 , C07D307/81 , C07D307/85 , C07D307/86 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38 , C07D333/70 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/04 , C07D417/12 , A61K2300/00
摘要： The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
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