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21.发明授权公开(公告)号：US10685906B2
公开(公告)日：2020-06-16
申请号：US16189787
申请日：2018-11-13
Applicant: International Business Machines Corporation
Inventor： Benjamin Wunsch , Joshua T. Smith , Stacey Gifford
IPC: H01L23/48 , H01L21/02 , H01L21/56 , H01L21/306 , H01L23/29 , H01L21/3213 , H01L21/48 , H01L21/033
Abstract: Devices and methods that can facilitate electrically conductive deterministic lateral displacement (DLD) pillar array components are provided. According to an embodiment, a device can comprise a substrate that can have a channel that can comprise electrically conductive pillar components that can be coupled to one or more electrodes. The device can further comprise a seal layer that can be coupled to the substrate that seals the one or more electrodes.
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公开(公告)号：US12011679B2
公开(公告)日：2024-06-18
申请号：US15815846
申请日：2017-11-17
Applicant: International Business Machines Corporation
Inventor： Stacey Gifford , Sung-Cheol Kim , Joshua Smith , Benjamin Wunsch
CPC classification number: B01D17/02 , B01D21/0087 , B01D21/2444 , B03B5/00 , G01N30/0005 , B82Y99/00 , G01N30/6095
Abstract: A fluidic processor device and a wafer including the same, the device including a nanofluidic separator chip including a nanoDLD array, a housing for housing the chip including a top plate disposed on a topside of the chip, a bottom plate disposed on a backside of the chip and fastened to the top plate, and a spacer disposed between the chip and the bottom plate to create a clearance between the chip and the bottom plate for forming a drain space on the backside of the chip.
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公开(公告)号：US11320387B2
公开(公告)日：2022-05-03
申请号：US16203195
申请日：2018-11-28
Applicant: International Business Machines Corporation
Inventor： Benjamin Wunsch , Sung-Cheol Kim , Stacey Gifford , Joshua T. Smith
Abstract: Techniques regarding one or more structures for checking the via formation are provided. For example, one or more embodiments described herein can comprise an apparatus, which can comprise a microfluidic channel positioned on a silicon substrate. The apparatus can also comprise a pattern of material comprised within the microfluidic channel and positioned on a surface of the silicon substrate. Further, the pattern of material can define a future location of a through-silicon via. An advantage of such an apparatus can be that the pattern of material can facilitate checking whether the through-silicon via is fully or partially formed.
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公开(公告)号：US20220033878A1
公开(公告)日：2022-02-03
申请号：US17501019
申请日：2021-10-14
Applicant: International Business Machines Corporation
Inventor： Stacey Gifford , Benjamin Wunsch , Joshua T. Smith , Sung-Cheol Kim
IPC: C12Q1/683 , C12Q1/6816
Abstract: Techniques regarding screening for mutations using nanoscale deterministic arrays are provided. For example, one or more embodiments described herein can comprise a method, which can comprise cleaving a deoxyribonucleic acid segment hybridized with a molecular probe to form a sample fluid. The cleaving can occur at a first end and a second end of the molecular probe. Also, the cleaving can comprise a cleaving agent that targets base pair mismatches. The method can also comprise supplying the sample fluid to a nanoscale deterministic lateral displacement array to screen for a single nucleotide polymorphism.
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公开(公告)号：US11173486B2
公开(公告)日：2021-11-16
申请号：US16274532
申请日：2019-02-13
Applicant: International Business Machines Corporation
Inventor： Evan Colgan , Joshua T. Smith , Benjamin Wunsch
Abstract: A method for fabricating a fluidic device includes depositing a sacrificial material on a pillar array arranged on a substrate. The method also includes removing a portion of the sacrificial material. The method further includes depositing a sealing layer on the pillar array to form a sealed fluidic cavity.
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Patent Agency Ranking
公开(公告)号：US11149298B2
公开(公告)日：2021-10-19
申请号：US16007347
申请日：2018-06-13
Applicant: International Business Machines Corporation
Inventor： Stacey Gifford , Sung-Cheol Kim , Joshua T. Smith , Benjamin Wunsch
IPC: G01N15/02 , C12Q1/6813 , C12Q1/6806 , C12Q1/6825 , G01N15/10
Abstract: Techniques regarding detecting one or more defined nucleic acid sequences are provided. For example, one or more embodiments described herein can comprise a method, which can comprise adding a molecular probe to a sample fluid comprising a first deoxyribonucleic acid segment and a second deoxyribonucleic acid segment. The molecular probe can have an affinity to bond to a defined nucleic acid sequence. The method can also comprise separating, via a nanoscale deterministic lateral displacement array, the first deoxyribonucleic acid segment from the second deoxyribonucleic acid segment based on a size of the first deoxyribonucleic acid segment.
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公开(公告)号：US20210260586A1
公开(公告)日：2021-08-26
申请号：US17314496
申请日：2021-05-07
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Benjamin Wunsch , Stacey Gifford , Sung-Cheol Kim
Abstract: Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.
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公开(公告)号：US20210146355A1
公开(公告)日：2021-05-20
申请号：US17162002
申请日：2021-01-29
Applicant: International Business Machines Corporation
Inventor： Evan Colgan , Joshua T. Smith , Benjamin Wunsch
Abstract: A method for fabricating a fluidic device includes depositing a sacrificial material on a pillar array arranged on a substrate. The method also includes removing a portion of the sacrificial material. The method further includes depositing a sealing layer on the pillar array to form a sealed fluidic cavity.
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公开(公告)号：US10967375B2
公开(公告)日：2021-04-06
申请号：US16168330
申请日：2018-10-23
Applicant: International Business Machines Corporation
Inventor： Joshua T. Smith , Benjamin Wunsch , Stacey Gifford
Abstract: Techniques regarding nanofluidic chips with a plurality of inlets and/or outlets in fluid communication with one or more nanoDLD arrays are provided. For example, one or more embodiments described herein can comprise a nanoscale deterministic lateral displacement array between and in fluid communication with a global inlet and a global outlet. The nanoscale deterministic lateral displacement array can further be between and in fluid communication with a local inlet and a local outlet. Also, the nanoscale deterministic lateral displacement array can laterally displace a particle comprised within a sample fluid supplied from the global inlet to a collection region that directs the particle to the local outlet. An advantage of such an apparatus can be the expanded versatility of the nanoscale deterministic lateral displacement array for sample preparation applications involving nanoparticles not accessible to other higher throughput microscale microfluidic technologies.
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公开(公告)号：US20200164367A1
公开(公告)日：2020-05-28
申请号：US16203171
申请日：2018-11-28
Applicant: International Business Machines Corporation
Inventor： Benjamin Wunsch , Joshua T. Smith , Stacey Gifford , Sung-Cheol Kim
IPC: B01L3/00
Abstract: Techniques regarding one or more structures that can facilitate automated, multi-stage processing of one or more nanofluidic chips are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a roller positioned adjacent to a microfluidic card comprising a plurality of fluid reservoirs in fluid communication with a plurality of nanofluidic chips. An arrangement of the plurality of nanofluidic chips on the microfluidic card can defines a processing sequence driven by a translocation of the roller across the microfluidic card.
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