公开(公告)号：US20180252687A1

公开(公告)日：2018-09-06

申请号：US15971150

申请日：2018-05-04

申请人： Tecan SP, Inc.

发明人： Philip A. Dimson

IPC分类号： G01N30/60 ,  B01D15/22 ,  G01N33/487 ,  B01D15/20 ,  G01N1/10 ,  G01N1/40

CPC分类号： G01N30/6065 ,  B01D15/206 ,  B01D15/22 ,  G01N1/10 ,  G01N1/405 ,  G01N30/6039 ,  G01N30/6069 ,  G01N30/6095 ,  G01N33/487 ,  G01N2001/4061

摘要： An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom one or more of: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii), optionally including one or more air gap layers. At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region. The apparatus may have a plurality of containers arranged in an array and/or in series so as to provide multi-stage filtration or extraction.

公开(公告)号：US09921194B2

公开(公告)日：2018-03-20

申请号：US15164841

申请日：2016-05-25

申请人： University of Electronic Science and Technology of China

发明人： Xiaosong Du ,  Huan Yuan ,  Xulan Zhao ,  Penglin Wu ,  Yadong Jiang

IPC分类号： G01N30/60 ,  G01N30/02

CPC分类号： G01N30/6086 ,  G01N30/6095 ,  G01N2030/025 ,  G01N2030/6056

摘要： A wavy micro gas chromatography column includes a silicon substrate and a bonded glass cover. A micro channel having a rectangular cross section is etched on the silicon substrate and coated with a stationary phase film. A projection figure of the micro channel on the silicon substrate includes multiple regular wavy curves. Each wavy curve is formed through alternately connecting first upper arcs with first lower arcs. Because the groove has a curving structure, the carrier gas velocity is decreased as the increase of the arc angle, resulting in an improvement of the flow uniformity at the zones between two adjacent bends but also an enlarging nonsymmetric distribution at the bends. Thus, an optimal curving structure can make the overall flow more even, and in turn achieve a better separation performance compared to the straight channel columns. Meanwhile, a wavy channel realizes a longer column length on a given area.

公开(公告)号：US09921191B2

公开(公告)日：2018-03-20

申请号：US14721833

申请日：2015-05-26

申请人： Agilent Technologies, Inc.

发明人： Xiao-Sheng Guan ,  Qiang Xu

IPC分类号： G01N30/28 ,  G01N30/02 ,  G01N30/32 ,  G01N30/60 ,  G01N30/88

CPC分类号： G01N30/28 ,  G01N30/32 ,  G01N30/6039 ,  G01N30/606 ,  G01N30/6095 ,  G01N2030/025 ,  G01N2030/324 ,  G01N2030/8881

摘要： A gas chromatographic (GC) unit or module may include one or more microfluidic devices, a GC column, and a flow controller (FC) comprising an FC input port for controlling fluid flows and pressures. The GC unit may be reconfigurable to provide different functionalities. The GC unit may be fluidly coupled to various other fluidic devices, such as other GC units, sample inlets, GC detectors, and the like. Multiple GC units and other fluidic devices may be utilized to build GC devices and associated systems of flexible, reconfigurable, and scalable architecture, thereby enabling a variety of modes of operation useful for present and future GC method development.

公开(公告)号：US09903843B2

公开(公告)日：2018-02-27

申请号：US14433717

申请日：2012-10-19

申请人： SHIMADZU CORPORATION

发明人： Masaki Kanai ,  Satoshi Matsuoka ,  Masanori Nishino ,  Takahiro Nishimoto

IPC分类号： G01N30/02 ,  G01N33/00 ,  G01N33/18

CPC分类号： G01N30/02 ,  G01N30/6026 ,  G01N30/6095 ,  G01N33/0009 ,  G01N33/1893 ,  Y10T137/598

摘要： A flow channel module comprises a flow channel plate, a flow channel connection block, and a pressing mechanism. The flow channel plate is provided with a main body and a protrusion section protruding in the circumferential direction from the peripheral edge of the main body, the protrusion section having a port communicating with an inner flow channel. The flow channel connection block is provided with a concave section for being engaged with the protrusion section and having inside a port facing surface for facing the port, and an outer flow channel connection section that is connected to the port facing surface by a flow channel. The pressing mechanism is configured to press the protrusion section inserted in the concave section and the port facing surface against each other so that the flow channel and the port are connected while maintaining air tightness or liquid tightness.

公开(公告)号：US20180031528A1

公开(公告)日：2018-02-01

申请号：US15549656

申请日：2016-02-05

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

发明人： Nils KULAK ,  Matthias MANN

IPC分类号： G01N30/60 ,  B01D15/32 ,  G01N30/80 ,  B01D15/24 ,  G01N30/38 ,  G01N30/74

CPC分类号： G01N30/6004 ,  B01D15/247 ,  B01D15/325 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N30/80 ,  G01N2030/027 ,  G01N2030/6013

摘要： The present invention relates to a device for preventing band broadening and remixing of separated fractions, and associated method, comprising a chromatographic column coupled to a flow selector, such as a rotary valve, wherein said flow selector is connected to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL. Preferably, the column is directly plugged into the inlet port of the rotary valve and the sample is fractionated at the outlet port.

公开(公告)号：US09804135B2

公开(公告)日：2017-10-31

申请号：US14594644

申请日：2015-01-12

申请人： Waters Technologies Corporation

发明人： Joseph D. Michienzi ,  James P. Murphy ,  Dennis DellaRovere

IPC分类号： G01L1/04 ,  G01N30/60 ,  B01L3/00 ,  G01N30/46 ,  B01D15/22 ,  B01D15/42 ,  G01N30/72 ,  G01N30/88 ,  G01N30/08 ,  G01N30/02

CPC分类号： G01N30/6095 ,  B01D15/22 ,  B01D15/424 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N30/461 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8881 ,  Y10T29/49826

摘要： An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining a second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.

公开(公告)号：US09791080B2

公开(公告)日：2017-10-17

申请号：US13686260

申请日：2012-11-27

申请人： IDEX Health & Science LLC

发明人： Craig Graham

IPC分类号： F16L37/244 ,  B01L3/00 ,  F16L15/08 ,  F16L19/02 ,  F16L19/065 ,  F16L21/00 ,  G01N30/88 ,  G01N30/60

CPC分类号： F16L37/244 ,  B01L3/502715 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0631 ,  B01L2200/0689 ,  B01L2300/0832 ,  B01L2300/0851 ,  F16L15/08 ,  F16L19/0237 ,  F16L19/065 ,  F16L21/00 ,  G01N30/6026 ,  G01N30/6095 ,  G01N30/88 ,  Y10T29/49826

摘要： A microfluidic interconnect system and method for assembly thereof is described. The microfluidic interconnect has a port and a seal, with the port having a reverse taper. The port has a first port end, a second port end, and an inner port surface with a tapered portion. Each port end has an opening with a diameter, and in certain embodiments, the diameter of the first port end is smaller than the diameter of the second port end. The seal has a first end and a second end, and each seal end has a rim and an opening with an inner diameter and an outer diameter. The seal also has an inner surface and an outer surface, where in certain embodiments, each surface has a tapered portion. In certain embodiments, the inner diameter of the first seal end is equal to or larger than the inner diameter of the second seal end, the outer diameter of the first seal end is equal to or smaller than the outer diameter of the second seal end, and the outer diameter of the second seal end is larger than the outer diameter of each port end. In certain embodiments, a tube is slidably coupled to the inner surface of the seal, and the tube has an outer diameter that is equal to or larger than the inner diameter of the second seal end.

公开(公告)号：US09719971B2

公开(公告)日：2017-08-01

申请号：US14483389

申请日：2014-09-11

申请人： Waters Technologies Corporation

发明人： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff Gerhardt

IPC分类号： G01N30/68 ,  G01N30/60

CPC分类号： G01N30/68 ,  G01N30/6095

摘要： The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.

公开(公告)号：US09683974B2

公开(公告)日：2017-06-20

申请号：US14678380

申请日：2015-04-03

申请人： TricornTech Corporation

发明人： Li-Peng Wang ,  Chien-Lin Huang ,  Tsung-Kuan A. Chou

IPC分类号： G01N30/46 ,  G01N30/30 ,  B01D53/04 ,  G01N30/60 ,  G01N30/88 ,  G01N30/02

CPC分类号： G01N30/30 ,  B01D53/0438 ,  B01D2259/402 ,  G01N30/461 ,  G01N30/463 ,  G01N30/6095 ,  G01N2030/025 ,  G01N2030/8881

摘要： The disclosure describes a cascaded gas chromatograph including a first gas chromatograph having a first temperature control and a second gas chromatograph coupled to the first gas chromatograph. The first and second chromatographs have individual temperature controls that can be controlled independently of each other. Other embodiments are disclosed and claimed.

公开(公告)号：US09678046B2

公开(公告)日：2017-06-13

申请号：US14488013

申请日：2014-09-16

申请人： BRIGHAM YOUNG UNIVERSITY

发明人： H. Dennis Tolley ,  Anzi Wang ,  Samuel E. Tolley ,  Milton L. Lee ,  Aaron R. Hawkins

IPC分类号： G01N30/30 ,  G01N30/60

CPC分类号： G01N30/30 ,  G01N30/6095 ,  G01N2030/3015

摘要： A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile.