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公开(公告)号：US11911762B2
公开(公告)日：2024-02-27
申请号：US17314496
申请日：2021-05-07
CPC分类号： B01L3/502753 , G06T7/0012 , B01L2300/0654
摘要： Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.
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公开(公告)号：US11186480B2
公开(公告)日：2021-11-30
申请号：US16276342
申请日：2019-02-14
摘要： An exemplary method includes forming a sacrificial layer along sidewalls of an array of trenches that are indented into a substrate, depositing a fill layer over the sacrificial layer, and then creating an array of gaps between the fill layer and the substrate by removing the sacrificial layer along the sidewalls of the trenches, while maintaining a structural connection between the substrate and the fill layer at the floors of the trenches. The method further includes covering the substrate, the fill layer, and the gaps with a cap layer that seal fluid-tight against the substrate and the fill layer. The method further includes indenting a first reservoir and a second reservoir through the cap layer, and into the substrate and the fill layer, across the lengths of the array of gaps, so that the array of gaps connects the first reservoir in fluid communication with the second reservoir.
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公开(公告)号：US20200166468A1
公开(公告)日：2020-05-28
申请号：US16203195
申请日：2018-11-28
摘要： Techniques regarding one or more structures for checking the via formation are provided. For example, one or more embodiments described herein can comprise an apparatus, which can comprise a microfluidic channel positioned on a silicon substrate. The apparatus can also comprise a pattern of material comprised within the microfluidic channel and positioned on a surface of the silicon substrate. Further, the pattern of material can define a future location of a through-silicon via. An advantage of such an apparatus can be that the pattern of material can facilitate checking whether the through-silicon via is fully or partially formed.
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公开(公告)号：US20190381505A1
公开(公告)日：2019-12-19
申请号：US16007107
申请日：2018-06-13
摘要： Multistage deterministic lateral displacement devices, methods of forming the devices, and methods of separating a fluid mixture including particles having three or more particle sizes generally include a first module and at least one additional module. Each module includes a condenser portion and a separate portion. The condenser portion is generally configured to focus a streamline of all particles to a center of a channel whereas the separator separates the streamline of all particles into two different streamlines. One of the streamlines focuses the largest particles in the fluid mixture along a sidewall of the channel and the other streamline of smaller particles is between opposing sidewalls that define the channel. Each additional module can be used to further separate the largest particles remaining in the fluid mixture from the smaller particles.
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公开(公告)号：US12129515B2
公开(公告)日：2024-10-29
申请号：US17501019
申请日：2021-10-14
IPC分类号： C12Q1/683 , C12Q1/6816
CPC分类号： C12Q1/683 , C12Q1/6816 , C12Q2600/156
摘要： Techniques regarding screening for mutations using nanoscale deterministic arrays are provided. For example, one or more embodiments described herein can comprise a method, which can comprise cleaving a deoxyribonucleic acid segment hybridized with a molecular probe to form a sample fluid. The cleaving can occur at a first end and a second end of the molecular probe. Also, the cleaving can comprise a cleaving agent that targets base pair mismatches. The method can also comprise supplying the sample fluid to a nanoscale deterministic lateral displacement array to screen for a single nucleotide polymorphism.
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公开(公告)号：US20230191398A1
公开(公告)日：2023-06-22
申请号：US18165434
申请日：2023-02-07
发明人： Evan Colgan , Joshua T. Smith , Benjamin Wunsch
CPC分类号： B01L3/502707 , B81C1/00309 , B81C1/00111 , B81B7/0061 , G01N15/0255 , B01L3/502715 , B01L3/502761 , B01L2300/12 , B81B2203/0361 , B81B2201/058 , G01N2015/0288 , B01L2200/0689 , B01L2200/0652 , B01L3/502753 , B01L3/502723
摘要： A method for fabricating a fluidic device includes depositing a sacrificial material on a pillar array arranged on a substrate. The method also includes removing a portion of the sacrificial material. The method further includes depositing a sealing layer on the pillar array to form a sealed fluidic cavity.
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公开(公告)号：US11548000B2
公开(公告)日：2023-01-10
申请号：US16203171
申请日：2018-11-28
IPC分类号： B01L3/00
摘要： Techniques regarding one or more structures that can facilitate automated, multi-stage processing of one or more nanofluidic chips are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a roller positioned adjacent to a microfluidic card comprising a plurality of fluid reservoirs in fluid communication with a plurality of nanofluidic chips. An arrangement of the plurality of nanofluidic chips on the microfluidic card can defines a processing sequence driven by a translocation of the roller across the microfluidic card.
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公开(公告)号：US11185861B2
公开(公告)日：2021-11-30
申请号：US16007107
申请日：2018-06-13
摘要： Multistage deterministic lateral displacement devices, methods of forming the devices, and methods of separating a fluid mixture including particles having three or more particle sizes generally include a first module and at least one additional module. Each module includes a condenser portion and a separate portion. The condenser portion is generally configured to focus a streamline of all particles to a center of a channel whereas the separator separates the streamline of all particles into two different streamlines. One of the streamlines focuses the largest particles in the fluid mixture along a sidewall of the channel and the other streamline of smaller particles is between opposing sidewalls that define the channel. Each additional module can be used to further separate the largest particles remaining in the fluid mixture from the smaller particles.
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公开(公告)号：US11094683B2
公开(公告)日：2021-08-17
申请号：US16364649
申请日：2019-03-26
IPC分类号： H01L25/00 , H01L23/00 , H01L25/065 , H01L25/04 , G01N33/487 , G01N33/50
摘要： A method of producing a bonded chip stack is described. A first nanofluidic device chip having a first through-wafer via is formed. A second nanofluidic device chip having a second through-wafer via is formed. The first nanofluidic device chip and the second nanofluidic device chip are washed with a detergent solution. A first surface of the first nanofluidic device chip and a second surface of the second nanofluidic device chip are activated by treating the first surface and the second surface with an activation solution. The first nanofluidic device chip and the second nanofluidic device chip are arranged in a stack. The first through-wafer via is aligned with the second through-wafer via in a substantially straight line. The stack of first and second nanofluidic device chips is subjected to annealing conditions.
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公开(公告)号：US11033901B2
公开(公告)日：2021-06-15
申请号：US16168228
申请日：2018-10-23
摘要： Techniques regarding integrated purification-detection devices for detecting one or more biomarkers are provided. For example, one or more embodiments described herein are directed to an apparatus, comprising a housing and a microfluidic chip contained within the housing. The microfluidic chip comprises a separation unit that separates, using one or more nano deterministic lateral displacement (nanoDLD) arrays, target biological entities having a defined size range from other biological entities included in a biological fluid sample. The microfluidic chip further comprises a detection unit that facilitates detecting presence of one or more biomarkers associated with the target biological entities using one or more detection molecules or macromolecules that chemically reacts with the one or more biomarkers.
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