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    COMPOUNDS AND METHODS
    21.
    发明申请
    COMPOUNDS AND METHODS 审中-公开

    公开(公告)号：US20170291904A1

    公开(公告)日：2017-10-12

    申请号：US15512005

    申请日：2015-09-17

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Hailin ZHENG ,  Jun ZHAO ,  Lawrence WENNOGLE

    IPC: C07D487/14

    CPC classification number: C07D487/14

    Abstract: The subject matter generally relates to compounds and methods of treatment and/or prophylaxis of CNS diseases, disorders, and/or injuries. In one aspect, the subject matter relates to inhibitors of phosphodiesterase 1 (PDE1) as neuroprotective agents and/or neural regenerative agents. In a further aspect, the subject matter relates to individuals that are at risk for the development of CNS disease or disorder.

    NOVEL HETEROCYCLE COMPOUNDS AND USES THEREOF
    22.
    发明申请
    NOVEL HETEROCYCLE COMPOUNDS AND USES THEREOF 审中-公开
    新型杂环化合物及其用途

    公开(公告)号：US20150259329A1

    公开(公告)日：2015-09-17

    申请号：US14727443

    申请日：2015-06-01

    Applicant: Intra-Cellular Therapies, Inc.

    Inventor： Peng LI

    IPC: C07D405/14 ,  C07D239/42 ,  C07D403/12 ,  C07D401/12

    CPC classification number: C07D405/14 ,  A61K31/4439 ,  A61K31/506 ,  A61K45/06 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

    Abstract: The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which penetrate the blood brain barrier, inhibit the formation and accumulation of beta-amyloid, and are useful in the treatment of neurodegenerative diseases, particularly Alzheimer's disease. Further, the compounds of the present invention inhibit certain kinases, thereby being useful for the treatment of cancers of the central nervous system.

    Abstract translation: 本发明涉及式（I）的化合物或其药学上可接受的盐：其渗透血脑屏障，抑制β-淀粉样蛋白的形成和积累，并且可用于治疗神经变性疾病，特别是阿尔茨海默病。 此外，本发明的化合物抑制某些激酶，因此可用于治疗中枢神经系统的癌症。

    NOVEL COMPOSITIONS AND METHODS
    23.
    发明申请
    NOVEL COMPOSITIONS AND METHODS 有权

    公开(公告)号：US20250009741A1

    公开(公告)日：2025-01-09

    申请号：US18893190

    申请日：2024-09-23

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Robert DAVIS

    IPC: A61K31/4985 ,  A61K9/70

    Abstract: The disclosure provides new transdermal pharmaceutical compositions comprising 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or 1-(4-fluoro-phenyl)-4-((6bR,10aS)-2,2-d2-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or comprising—(4-fluoro-phenyl)-4-((6bR,10aS)-1,1,2,2-d4-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one, in free base, co-crystal or salt form, together with methods of making and using them.

    SALT CRYSTALS
    24.
    发明公开
    SALT CRYSTALS 审中-公开

    公开(公告)号：US20240101569A1

    公开(公告)日：2024-03-28

    申请号：US18263302

    申请日：2022-01-27

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI

    IPC: C07D487/14

    CPC classification number: C07D487/14

    Abstract: The present disclosure relates to free base and salt crystals of 2-(4-acetylbenzyl)-3-((4-fluorophenyl)amino)-5,7,7-trimethyl-7,8-dihydro-2H-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one, composition comprising the same and the method of making and using such free base and salt crystals.

    ORGANIC COMPOUND
    28.
    发明申请
    ORGANIC COMPOUND 有权

    公开(公告)号：US20230021717A1

    公开(公告)日：2023-01-26

    申请号：US17757212

    申请日：2020-12-10

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Robert E DAVIS ,  Kimberly Vanover

    IPC: C07D519/00

    Abstract: The invention relates to a particular substituted heterocycle fused gamma-carboline, the compound of Formula I, and new methods and uses pertaining thereto, and pharmaceutical compositions thereof, such as methods of use in the treatment of diseases involving the 5-HT receptor, the serotonin transporter (SERT), and/or pathways involving dopamine D2 receptor signaling, sodium channel activity, and/or norepinephrine transporter activity.

    NOVEL METHODS
    29.
    发明申请
    NOVEL METHODS 有权

    公开(公告)号：US20220142932A1

    公开(公告)日：2022-05-12

    申请号：US17582516

    申请日：2022-01-24

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Robert DAVIS

    IPC: A61K9/48 ,  A61K31/4985 ,  A61K45/06

    Abstract: The present disclosure relates to pharmaceutical capsules comprising lumateperone, in free, or pharmaceutically acceptable salt form, optionally in combination with one or more additional therapeutic agents, processes for manufacture thereof and methods of use in the treatment or prophylaxis of disease.

    NOVEL COMPOUNDS
    30.
    发明申请
    NOVEL COMPOUNDS 有权

    公开(公告)号：US20220064169A1

    公开(公告)日：2022-03-03

    申请号：US17288225

    申请日：2019-10-23

    Applicant: INTRA-CELLULAR THERAPIES, INC.

    Inventor： Peng LI ,  Hailin ZHENG

    IPC: C07D487/04

    Abstract: The present disclosure relates to novel PDE2 inhibitory compounds of Formula I as described herein, their use as pharmaceuticals and pharmaceutical compositions comprising them.

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