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21.发明申请Triazole compounds and their use as metabotropic glutamate receptor antagonists 审中-公开三唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070185178A1
公开(公告)日：2007-08-09
申请号：US10588751
申请日：2005-02-17
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Johan Malmberg , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , David Wensbo , Tao Xin , Tomislav Stefanac
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Johan Malmberg , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , David Wensbo , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/4439 , A61K31/41
CPC分类号： C07D401/12 , C07D231/12 , C07D231/14 , C07D249/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy, especially for the treatment of mGluR5 receptor mediated disorders, and for the treatment of neurological disorders, psychiatric disorders, gastrointestinal disorders and pain disorders.
摘要翻译： 本发明涉及新的式（I）化合物，其中P，Q，X 1，X 2，X 3，X 3， X 4，X 7，X 8，R 1，R 2，R 2， 其中，m，n和p如式（I）中所定义，或其盐或其水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和 涉及在治疗中使用所述化合物，特别是用于治疗mGluR5受体介导的病症，以及用于治疗神经障碍，精神疾病，胃肠道疾病和疼痛障碍。
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22.发明申请New compounds for the treatment of neurological, psychiatric or pain disorders 失效用于治疗神经，精神或疼痛疾病的新化合物公开(公告)号：US20070129408A1
公开(公告)日：2007-06-07
申请号：US11523717
申请日：2006-09-20
申请人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
发明人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译： 本发明涉及新化合物，它们在治疗中的用途和包含所述新化合物的药物组合物。
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23.发明授权公开(公告)号：US07476684B2
公开(公告)日：2009-01-13
申请号：US11523717
申请日：2006-09-20
申请人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
发明人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译： 本发明涉及新化合物，它们在治疗中的用途和包含所述新化合物的药物组合物。
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24.发明申请5-(Phenylisoxazolylethoxy) - Triazol- 3 -Yl Substituted Pyridine Compounds for the Treatment of Neurological, Psychiatric or Pain Disorders 审中-公开5-（苯基异恶唑基聚乙氧基） - 三唑-3-基取代的吡啶化合物，用于治疗神经，精神或疼痛疾病公开(公告)号：US20080227824A1
公开(公告)日：2008-09-18
申请号：US12067270
申请日：2006-09-20
申请人： Alexander Minidis , David Wensbo , Abdelmalik Slassi , Methvin Isaac , Caroline Ericsson , Veronica Profir , Per-Olov Bergstrom , Louise Edwards , Jalaj Arora , Tao Xin
发明人： Alexander Minidis , David Wensbo , Abdelmalik Slassi , Methvin Isaac , Caroline Ericsson , Veronica Profir , Per-Olov Bergstrom , Louise Edwards , Jalaj Arora , Tao Xin
IPC分类号： A61K31/4525 , C07D413/14 , A61P25/00 , A61P25/14
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds of formula (I)/(II)/(III), their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译： 本发明涉及式（I）/（II）/（III）的新化合物，它们在治疗中的用途和包含所述新化合物的药物组合物。
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公开(公告)号：US20080125436A1
公开(公告)日：2008-05-29
申请号：US11902784
申请日：2007-09-25
申请人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Peter Dove , Tao Xin , Tomislav Stefanac
发明人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Peter Dove , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/513 , A61K31/501 , A61K31/497 , A61K31/4439 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D413/14 , C07D401/14
摘要： The present invention is directed to compounds of formula I: Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译： 本发明涉及式I化合物：其中R 1至R 5，X和Z在说明书中进一步定义。 本发明还涉及制备化合物和制备中使用的方法，含有该化合物的药物组合物以及该化合物在治疗中的用途。
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公开(公告)号：US06380242B1
公开(公告)日：2002-04-30
申请号：US09469327
申请日：1999-12-22
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Ashok Tehim , Tao Xin
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Ashok Tehim , Tao Xin
IPC分类号： A61K31382
CPC分类号： A61K31/415
摘要： The present invention is directed to compounds useful in the treatment of migraine which have the general formula (II).
摘要翻译： 本发明涉及可用于治疗具有通式（II）的偏头痛的化合物。
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公开(公告)号：US07772235B2
公开(公告)日：2010-08-10
申请号：US11902784
申请日：2007-09-25
申请人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Peter Dove , Tao Xin , Tomislav Stefanac
发明人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Peter Dove , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/50 , A61K31/44 , C07D403/14 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present invention is directed to compounds of formula I: Wherein R1 to R5, X and Z are further defined in the description. The invention also relates to processes for the preparation of the compounds and to intermediates used in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译： 本发明涉及式I化合物：其中R1至R5，X和Z在本说明书中进一步定义。 本发明还涉及制备化合物和制备中使用的方法，含有该化合物的药物组合物以及该化合物在治疗中的用途。
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公开(公告)号：US20070259926A1
公开(公告)日：2007-11-08
申请号：US11790416
申请日：2007-04-25
申请人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Tao Xin , Tomislav Stefanac
发明人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/4439 , C07D403/14
CPC分类号： C07D403/04 , C07D401/14 , C07D413/14
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
摘要翻译： 本发明涉及新化合物，其制备方法，其在治疗中的应用和包含新化合物的药物组合物。
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公开(公告)号：US20070259916A1
公开(公告)日：2007-11-08
申请号：US11790415
申请日：2007-04-25
申请人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Tao Xin , Tomislav Stefanac
发明人： Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/4545 , C07D403/14
CPC分类号： C07D401/14 , C07D211/60 , C07D401/04 , C07D413/04 , C07D413/14
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
摘要翻译： 本发明涉及新化合物，其制备方法，其在治疗中的应用和包含新化合物的药物组合物。
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公开(公告)号：US07678796B2
公开(公告)日：2010-03-16
申请号：US11790417
申请日：2007-04-25
申请人： Andreas Wallberg , Karolina Nilsson , Björn Holm , Mats Nagard , Kenneth Granberg , Abdelmalik Slassi , Louise Edwards , Methvin Isaac , Tao Xin , Tomislav Stefanac
发明人： Andreas Wallberg , Karolina Nilsson , Björn Holm , Mats Nagard , Kenneth Granberg , Abdelmalik Slassi , Louise Edwards , Methvin Isaac , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/513 , A61K31/497 , A61K31/496 , A61K31/501 , C07D413/02 , C07D417/14 , A61P1/00
CPC分类号： C07D413/14 , C07D401/14 , C07D403/14
摘要： The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
摘要翻译： 本发明涉及新化合物，其制备方法，其在治疗中的应用和包含新化合物的药物组合物。
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