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1.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070179188A1
公开(公告)日：2007-08-02
申请号：US10588702
申请日：2005-02-15
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4245 , C07D413/14 , C07D413/02
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式（I）化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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2.发明申请Triazole compounds and their use as metabotropic glutamate receptor antagonists 审中-公开三唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20060019997A1
公开(公告)日：2006-01-26
申请号：US11060366
申请日：2005-02-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Johan Malmberg , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , David Wensbo , Tomislav Stefanac , Tao Xin
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Johan Malmberg , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , David Wensbo , Tomislav Stefanac , Tao Xin
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , C07D413/14 , C07D403/14
CPC分类号： C07D401/12 , C07D231/12 , C07D231/14 , C07D249/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4 X7, X8, R1, R2, R3, m, n, and p are as defined as in formula I, or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， 4个X 7，X 8，R 1，R 2，R 3， m，n和p如式I所定义，或其盐或水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物以及所述化合物的用途 化合物治疗。
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3.发明申请Triazole compounds and their use as metabotropic glutamate receptor antagonists 审中-公开三唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070185178A1
公开(公告)日：2007-08-09
申请号：US10588751
申请日：2005-02-17
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Johan Malmberg , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , David Wensbo , Tao Xin , Tomislav Stefanac
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Johan Malmberg , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , David Wensbo , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/4439 , A61K31/41
CPC分类号： C07D401/12 , C07D231/12 , C07D231/14 , C07D249/06 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy, especially for the treatment of mGluR5 receptor mediated disorders, and for the treatment of neurological disorders, psychiatric disorders, gastrointestinal disorders and pain disorders.
摘要翻译： 本发明涉及新的式（I）化合物，其中P，Q，X 1，X 2，X 3，X 3， X 4，X 7，X 8，R 1，R 2，R 2， 其中，m，n和p如式（I）中所定义，或其盐或其水合物，其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和 涉及在治疗中使用所述化合物，特别是用于治疗mGluR5受体介导的病症，以及用于治疗神经障碍，精神疾病，胃肠道疾病和疼痛障碍。
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4.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20080045571A1
公开(公告)日：2008-02-21
申请号：US11840953
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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5.发明申请公开(公告)号：US20080015234A1
公开(公告)日：2008-01-17
申请号：US11840952
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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6.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20050272779A1
公开(公告)日：2005-12-08
申请号：US11053752
申请日：2005-02-09
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4245 , A61K31/4439 , C07D413/14
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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7.发明申请Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 审中-公开四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070197549A1
公开(公告)日：2007-08-23
申请号：US10588756
申请日：2005-02-17
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/445 , A61K31/41 , A61K31/519 , C07D239/02 , C07D249/08
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds, and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， R 1，R 2，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐，用于它们的 制剂和用于制备其中的新中间体，含有所述化合物的药物组合物以及所述化合物在治疗中的用途。
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8.发明申请Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开稠合杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070185095A1
公开(公告)日：2007-08-09
申请号：US10588699
申请日：2005-02-17
申请人： Martin Johansson , David Wensbo , Alexander Minidis , Karin Staaf , Annika Kers , Louise Edwards , Methvin Isaac , Tomislav Stefanac , Abdelmalik Slassi , Donald McLeod , Tao Xin
发明人： Martin Johansson , David Wensbo , Alexander Minidis , Karin Staaf , Annika Kers , Louise Edwards , Methvin Isaac , Tomislav Stefanac , Abdelmalik Slassi , Donald McLeod , Tao Xin
IPC分类号： A61K31/551
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention is directed to compounds of formula: (I); wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds for treating gastrointestinal disorders.
摘要翻译： 本发明涉及式（I）的化合物： 其中X 1，X 2，X 3，X 4，X 5， ，X 6，X 7，X 8，X 9，X 10， R 1，R 2，R 3，R 4，和n如式I中所定义。 说明。 本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物用于治疗胃肠道疾病的用途。
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9.发明申请公开(公告)号：US20080015204A1
公开(公告)日：2008-01-17
申请号：US11840955
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/519 , A61K31/4196 , A61K31/4245 , A61P19/02 , A61P25/08 , A61P25/28 , A61P27/02 , A61P35/00 , C07D271/06 , C07D487/04 , C07D413/14 , A61P9/00 , A61P29/00 , A61P25/30 , A61P25/18 , A61P19/06 , A61K31/443 , A61K31/4439
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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10.发明授权Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 失效四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US07691892B2
公开(公告)日：2010-04-06
申请号：US11060463
申请日：2005-02-18
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 4，R 1，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐， 其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。
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