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31 条记录 (耗时 0.05 秒)

    IMIDAZOLE-2-THIONES
    23.
    发明申请
    IMIDAZOLE-2-THIONES 有权
    咪唑-2 -THIONES

    公开(公告)号：US20080091028A1

    公开(公告)日：2008-04-17

    申请号：US11873537

    申请日：2007-10-17

    申请人： Ken Chow ,  Todd Heidelbaugh ,  Daniel Gil ,  Michael Garst ,  Larry Wheeler

    发明人： Ken Chow ,  Todd Heidelbaugh ,  Daniel Gil ,  Michael Garst ,  Larry Wheeler

    IPC分类号： C07D215/12 ,  C07D215/02 ,  C07D215/22 ,  C07D233/06 ,  C07D233/30

    CPC分类号： C07D233/84 ,  C07D233/70 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/08

    摘要： Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.

    摘要翻译： 式1的化合物，其中X为S且变量具有本说明书中定义的含义，优先选择于α2B2和/或α2C2肾上腺素能受体 2A肾上腺素能受体，因此没有或仅有最小的血管内和/或镇静作用。 式1的这些化合物可用作哺乳动物（包括人）中的药物，用于治疗疾病和/或缓解对α2B2肾上腺素能受体的激动剂治疗有反应的病症。 其中X是O的式1化合物也具有它们没有或只有最小的血管内和/或镇静作用的有利性质，并且可用于治疗没有或仅有最小血管和/或镇静作用的疼痛和其它病症。

    Therapeutic methods using prostaglandin EP4 agonist components
    24.
    发明申请
    Therapeutic methods using prostaglandin EP4 agonist components 有权
    使用前列腺素EP4激动剂组分的治疗方法

    公开(公告)号：US20070123568A1

    公开(公告)日：2007-05-31

    申请号：US11291694

    申请日：2005-11-30

    申请人： Guang-Liang Jiang ,  Wha Bin Im ,  Larry Wheeler

    发明人： Guang-Liang Jiang ,  Wha Bin Im ,  Larry Wheeler

    IPC分类号： A61K31/558 ,  A61K31/557

    CPC分类号： A61K31/00 ,  A61K9/5078 ,  A61K31/45 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/558

    摘要： Methods are provides directed to administering a therapeutically effective amount of a prostaglandin EP4 agonist component to a mammal afflicted with or prone to affliction with a disease or condition selected from an esophageal ulcer, alcohol gastropathy, a duodenal ulcer, non-steroidal anti-inflammatory drug-induced gastroentroeropathy and intestinal ischemia. Such administration results in treating or preventing the disease or condition.

    摘要翻译： 提供的方法涉及将治疗有效量的前列腺素EP 4激动剂组分施用于患有或易于患有选自食管溃疡，酒精性胃病，十二指肠溃疡的疾病或病症的哺乳动物 ，非甾体抗炎药物诱导的胃肠病和肠缺血。 这种给药导致治疗或预防疾病或病症。

    IMIDAZOLE-2-THIONES
    29.
    发明申请
    IMIDAZOLE-2-THIONES 失效
    咪唑-2 -THIONES

    公开(公告)号：US20080097103A1

    公开(公告)日：2008-04-24

    申请号：US11873500

    申请日：2007-10-17

    申请人： Ken Chow ,  Todd Heidelbaugh ,  Daniel Gil ,  Michael Garst ,  Larry Wheeler

    发明人： Ken Chow ,  Todd Heidelbaugh ,  Daniel Gil ,  Michael Garst ,  Larry Wheeler

    IPC分类号： C07D233/84 ,  C07D401/02 ,  C07D405/06 ,  C07D409/02

    CPC分类号： C07D233/84 ,  C07D233/70 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/08

    摘要： Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardiovascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardiovascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardiovascular and/or sedatory activity.

    摘要翻译： 式1的化合物，其中X为S且变量具有本说明书中定义的含义，优先选择于α2B2和/或α2C2肾上腺素能受体 2A肾上腺素能受体，因此没有或仅有最小的心血管和/或镇静活性。 式1的这些化合物可用作哺乳动物（包括人）中的药物，用于治疗疾病和/或缓解对α2B2肾上腺素能受体的激动剂治疗有反应的病症。 其中X为O的式1的化合物也具有它们没有或只有最小的心血管和/或镇静活性的有利特性，并且可用于治疗没有或仅有最小的心血管和/或镇静活性的疼痛和其它状况。