摘要:
This invention relates to novel sulfone 2I3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
摘要:
A flexible and disposable allergen-containing patch is provided with markings transferable to the skin. The patch may also include piercing elements to become an all-in-one system. A reusable actuator enables a user with little training or experience to administer multiple test injections with the disposable patch. A scope allows magnified viewing of a test site after the skin test is provided, the scope incorporating the patch as a releasable component. An all-in-one applicator assembly that can be bent to fit a convex engagement surface of a rolling actuator is also provided.
摘要:
Disclosed herein are methods and devices for securing soft tissue to a rigid material such as bone. A surgical device having a jaw assembly with a sharpened beak-shaped tip and an aperture suitable for receiving a suture anchor is described. The surgical device includes slots in the side of the aperture through which suture that is attached to the anchor can be disengaged from the device.
摘要:
A customized hubcap attachment system to provide interchangeable hubcaps allowing use of different ornamental hubcaps for different occasions includes a wheel with an interior rim, a hubcap mount attachable to said wheel interior rim, and an interchangeable hubcap plate removably attachable to the hubcap mount. A customized hubcap attachment kit.
摘要:
A fuel tank venting system includes a fuel cap, a vent diaphragm and a vent disc. A valve cavity with a substantially concave bottom is formed in a bottom of the fuel cap. At least one air passage is formed through the vent disc. A substantially convex surface is formed on a top of the diaphragm projection. The vent diaphragm is retained between the substantially concave bottom and the substantially convex surface. When air is needed for fuel flow, a vacuum within the fuel tank pulls the perimeter of the vent diaphragm downward, which breaks a seal with the substantially concave bottom to allow air flow. In a second embodiment, the fuel tank venting system is contained in a wall of the fuel tank. In a third embodiment, the fuel tank venting system is contained in a fuel vent body, which is attached to the fuel tank.
摘要:
The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要:
The present invention discloses methods of screening a subject for Parkinson's disease comprising detecting the presence or absence of a marker or functional polymorphism associated with a gene linked to Parkinson's disease.
摘要:
A kayak anchor support system includes a first support arm having a first end opposite a second end, wherein the first support arm is removably securable to a kayak via at least one mounting bracket. A proximal end of a second support arm is affixed to the first support arm adjacent to the first end. The second support arm extends orthogonally from the first support arm such that a distal end of the second support arm is maintained in an elevated position above the kayak. A pulley is affixed to the distal end of the second support arm. An anchor cable is engaged with each of the pulley and a reel, wherein the reel is disposed opposite the pulley. An anchor is affixed to a terminal end of the anchor cable, whereupon actuation of the reel, the anchor is selectively movable between a raised position and a lowered positioned.
摘要:
The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which A, R1, R3 and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要:
Various safety systems for power tools, and in particular table saws include detection systems for detecting a dangerous condition relative to a blade of the power tool, reaction systems for taking mitigation action in response to detection of a dangerous condition. The safety system may detect, prevent, and/or mitigate a dangerous condition associated with the power tool.