公开(公告)号：US08103347B2

公开(公告)日：2012-01-24

申请号：US12109866

申请日：2008-04-25

申请人： John H. Erickson

发明人： John H. Erickson

IPC分类号： A61N1/00

CPC分类号： A61N1/37 ,  A61N1/086 ,  A61N1/3718

摘要： In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.

公开(公告)号：US20110273225A1

公开(公告)日：2011-11-10

申请号：US13185114

申请日：2011-07-18

申请人： Benjamin A. Tranchina ,  John H. Erickson ,  Anthony J. Varrichio

发明人： Benjamin A. Tranchina ,  John H. Erickson ,  Anthony J. Varrichio

IPC分类号： G05F1/10

CPC分类号： A61N1/025 ,  H02M3/07

摘要： Disclosed are systems and methods which provide voltage conversion in increments less than integer multiples of a power supply (e.g., battery) voltage. A representative embodiment provides power supply voltage multipliers in a binary ladder distribution to provide a desired number of output voltage steps using a relatively uncomplicated circuit design. By using different sources in various combinations and/or by “stacking” different sources in various ways, the voltage multiplier circuit may be used to provide desired voltages. In order to minimize the number of components used in a voltage converter of an embodiment, a capacitive voltage converter circuit uses one or more storage capacitors in place of pump capacitors in a voltage generation cycle. Also, certain embodiments do not operate to generate an output voltage until the time that voltage is needed.

摘要翻译： 公开了以小于电源（例如，电池）电压的整数倍的增量提供电压转换的系统和方法。 代表性的实施例提供二进制梯形分布中的电源电压倍增器，以使用相对简单的电路设计提供期望数量的输出电压步长。 通过以各种方式使用不同的源和/或以不同的方式“堆叠”不同的源，可以使用电压倍增器电路来提供期望的电压。 为了最小化实施例的电压转换器中使用的部件的数量，电容性电压转换器电路在电压产生循环中使用一个或多个存储电容器代替泵电容器。 而且，某些实施例在直到需要电压的时间之前不会产生输出电压。

公开(公告)号：US20110144721A1

公开(公告)日：2011-06-16

申请号：US12814968

申请日：2010-06-14

申请人： Thomas K Hickman ,  Erick D. Engstrom ,  Matthew J. Brock ,  John H. Erickson

发明人： Thomas K Hickman ,  Erick D. Engstrom ,  Matthew J. Brock ,  John H. Erickson

IPC分类号： A61N1/36

CPC分类号： A61N1/36192 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3758 ,  A61N1/3787 ,  G16H40/63

摘要： In one embodiment, a method of programming an IPG comprises providing one or several GUI screens on the programmer device, the GUI screens comprising a master amplitude GUI control for controlling amplitudes for stimsets of a stimulation program and one or several balancing GUI controls for controlling amplitudes of each stimset of the stimulation program; communicating one or several commands from the programmer device to the IPG to change the amplitude of all stimsets of the stimulation program in response to manipulation of the master amplitude GUI control, wherein the amplitude of each stimulation set is automatically calculated by a level selected through the master amplitude GUI control and one or several calibration parameters for the respective stimulation set; and automatically recalculating the one or several calibration parameters for a respective stimulation set in response to manipulation of one of the balancing GUI controls and storing the recalculated calibration parameters.

摘要翻译： 在一个实施例中，编程IPG的方法包括在编程器设备上提供一个或多个GUI屏幕，GUI屏幕包括用于控制刺激程序的刺激的幅度的主幅度GUI控制和用于控制幅度的一个或多个平衡GUI控件 刺激计划的每个刺激; 将一个或多个命令从编程器设备传送到IPG，以响应于主幅度GUI控制的操纵来改变刺激程序的所有刺激的幅度，其中每个刺激集合的幅度被自动计算通过 主幅度GUI控制和用于各个刺激组的一个或几个校准参数; 以及响应于所述平衡GUI控件之一的操纵并且存储所述重新计算的校准参数而自动重新计算相应刺激组的所述一个或多个校准参数。

公开(公告)号：US20100004637A1

公开(公告)日：2010-01-07

申请号：US10966360

申请日：2004-10-15

申请人： John H. Erickson

发明人： John H. Erickson

IPC分类号： A61M5/168 ,  A61K9/22

CPC分类号： A61M5/14276 ,  A61M5/16881 ,  A61M2210/1003

摘要： There is disclosed a system and method for allowing use within a body of devices having material not known for its biocompatibility with the body. In one embodiment, a magnetically controlled solenoid/valve is used where portions of the valve are directly in contact with compositions that are to be delivered to a target site. Advantage is taken of an existing solenoid/valve having chromium alloy parts by coating the portions of the valve that contact the deliverable composition with a known biocompatible material having good wear resistance. In one embodiment, titanium nitride (TiN) is used as the coating material.

摘要翻译： 公开了一种允许在身体内使用具有与人体生物相容性不知道的材料的系统和方法。 在一个实施例中，使用磁控螺线管/阀，其中阀的部分直接与将被输送到目标位置的组合物接触。 通过用具有良好耐磨性的已知生物相容性材料涂覆接触可递送组合物的阀的部分，可以获得具有铬合金部件的现有螺线管/阀。 在一个实施例中，使用氮化钛（TiN）作为涂层材料。

公开(公告)号：US20090326608A1

公开(公告)日：2009-12-31

申请号：US12491786

申请日：2009-06-25

申请人： Jeffrey C. Huynh ,  Daniel Powell ,  Vikram Gaonkar ,  John H. Erickson

发明人： Jeffrey C. Huynh ,  Daniel Powell ,  Vikram Gaonkar ,  John H. Erickson

IPC分类号： A61N1/08

CPC分类号： A61N1/37247 ,  A61N1/0551 ,  A61N1/36185 ,  A61N1/37252

摘要： In one embodiment, a method for assisting programming a pulse generator comprises: defining a set of unique electrode combinations in the controller device, each electrode combination within the set providing a unique locus of stimulation for a single stimulation pulse applied at a base location relative to loci of stimulation of other electrode combinations, the set of unique electrode combinations defining a two-dimensional range of multiple loci of stimulation; providing one or more user interfaces to the clinician to control pulse generation and delivery by the single-source pulse generator; and processing input from the clinician related to relocation of a locus of stimulation, the processing comprising (i) automatically selecting an electrode combination from the set, and (ii) automatically modifying an electrode combination used by the single-source pulse generator to deliver electrical stimulation pulses to the selected electrode combination.

摘要翻译： 在一个实施例中，用于辅助编程脉冲发生器的方法包括：在控制器设备中定义一组独特的电极组合，该组内的每个电极组合为相对于基底位置施加的单个刺激脉冲提供唯一的刺激轨迹 刺激其他电极组合的位点，该组独特的电极组合定义了多个刺激位点的二维范围; 向所述临床医生提供一个或多个用户界面以控制所述单源脉冲发生器的脉冲产生和传递; 以及处理来自临床医生的与重新定位刺激点相关的输入，所述处理包括（i）从所述组中自动选择电极组合，以及（ii）自动修改由单源脉冲发生器使用的电极组合以传送电 刺激脉冲到所选择的电极组合。

公开(公告)号：US20090024187A1

公开(公告)日：2009-01-22

申请号：US12243632

申请日：2008-10-01

申请人： John H. Erickson ,  George Van Campen ,  Patrick M. Cullen ,  Thomas K. Hickman

发明人： John H. Erickson ,  George Van Campen ,  Patrick M. Cullen ,  Thomas K. Hickman

IPC分类号： A61N1/36

CPC分类号： A61N1/37247 ,  A61N1/36017 ,  A61N1/3605 ,  A61N1/37241

摘要： Disclosed are systems and methods which provide trial stimulators suited for use interoperatively and during patient trial. Trial stimulator embodiments provide a patient interface and/or clinician interface which appears and functions substantially the same as an interface of a pulse generator controller which will be used after a trial period. A compliance monitor feature may be provided to facilitate verifying the proper use of the trial stimulator during a trial period. A diagnostic feature may be provided to facilitate verifying proper operation of various aspects of a trial stimulator, such as electrode impedance analysis. Trial stimulators of embodiments provide stimulation to a plurality of tissues and/or areas of the body, such as spinal cord stimulation, deep brain stimulation, etcetera. Embodiments provide for multi-electrode stimulation and multi-stimulation programs. Embodiments are configured to provide active discharge of stimulation pulses as well as to utilize constant current sources in providing the stimulation pulses.

摘要翻译： 公开了提供适合于在手术期间和在患者试验期间使用的试验刺激物的系统和方法。 试验刺激器实施例提供患者接口和/或临床医师界面，该接口出现并且功能基本上与在试用期之后使用的脉冲发生器控制器的接口相同。 可以提供合规监测功能以便于在试用期间验证试用刺激器的正确使用。 可以提供诊断特征以便于验证试验刺激器的各个方面的正确操作，例如电极阻抗分析。 实施例的刺激器可以对身体的多个组织和/或区域提供刺激，例如脊髓刺激，深部脑刺激等。 实施例提供多电极刺激和多刺激程序。 实施例被配置为提供刺激脉冲的主动放电以及在提供刺激脉冲时利用恒定电流源。

公开(公告)号：US07254446B1

公开(公告)日：2007-08-07

申请号：US11073026

申请日：2005-03-04

申请人： John H. Erickson ,  Thomas K. Hickman ,  Erik D. Engstrom

发明人： John H. Erickson ,  Thomas K. Hickman ,  Erik D. Engstrom

IPC分类号： A61N1/00 ,  A61B5/05

CPC分类号： A61N1/37235 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/36185 ,  A61N1/3787

摘要： A system, method, and computer program product for calibrating a stimulation device such as an implantable pulse generator (IPG). An IPG, whether it is a self-contained implantable pulse generator (SCIPG) or externally-powered implantable pulse generator (EPIPG), communicates with an external programmer to determine the characteristics of the stimuli delivered to the lead electrodes. An external programmer is used with patient feedback to determine initial threshold levels, and using the initial threshold levels, to determine threshold levels for combined electrode arrays.

摘要翻译： 一种用于校准诸如可植入脉冲发生器（IPG）的刺激装置的系统，方法和计算机程序产品。 IPG，无论是独立的可植入脉冲发生器（SCIPG）还是外部供电的可植入脉冲发生器（EPIPG），与外部编程器通信以确定传递到引线电极的刺激特性。 外部编程器用于患者反馈以确定初始阈值电平，并使用初始阈值电平来确定组合电极阵列的阈值电平。

公开(公告)号：US5766231A

公开(公告)日：1998-06-16

申请号：US730493

申请日：1996-10-11

申请人： John H. Erickson ,  John C. Tepper ,  Ike C. Thacker ,  Gregg Turi ,  Anthony J. Varrichio ,  Arthur A. Pilla ,  Mark A. Bettin ,  William C. Brosche

发明人： John H. Erickson ,  John C. Tepper ,  Ike C. Thacker ,  Gregg Turi ,  Anthony J. Varrichio ,  Arthur A. Pilla ,  Mark A. Bettin ,  William C. Brosche

IPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/18 ,  A61N1/32 ,  A61N1/36

CPC分类号： A61N1/3605 ,  A61N1/05 ,  A61N1/08 ,  A61N1/326 ,  Y10S128/903

摘要： A hand-held programmer/monitor (500) for programming and monitoring an implantable tissue growth stimulator (10) is provided. The stimulator (10) includes circuitry (46) for implementing selected operations in response to a down-link signal transmitted by the programmer/monitor (500). The stimulator (10) also includes circuitry (14) for transmitting up-link signals to the programmer/monitor (500). The programmer/monitor (500) includes a control circuit (518) for generating the down-link signal. The control circuit (518) also processes the up-link signal to monitor the status of the implantable tissue growth stimulator (10). The programmer/monitor (500) also includes a transmit/receive circuit (514) for transmitting the down-link signal to and for receiving the up-link signal from the implantable tissue growth stimulator (10). The transmit/receive circuit (514) also couples the up-link signal to the control circuit (518).

摘要翻译： 提供了一种用于编程和监测植入式组织生长刺激器（10）的手持编程器/监视器（500）。 刺激器（10）包括用于响应于由编程器/监视器（500）发送的下行链路信号来实现所选择的操作的电路（46）。 刺激器（10）还包括用于向编程器/监视器（500）发送上行链路信号的电路（14）。 编程器/监视器（500）包括用于产生下行链路信号的控制电路（518）。 控制电路（518）还处理上行链路信号以监视可植入组织生长刺激器（10）的状态。 编程器/监视器（500）还包括发送/接收电路（514），用于将下行链路信号发送到可植入组织生长刺激器（10）并用于从可植入组织生长刺激器（10）接收上行链路信号。 发射/接收电路（514）还将上行链路信号耦合到控制电路（518）。

公开(公告)号：US5401233A

公开(公告)日：1995-03-28

申请号：US186383

申请日：1994-01-25

申请人： John H. Erickson ,  John C. Tepper

发明人： John H. Erickson ,  John C. Tepper

IPC分类号： A61N2/02 ,  A61N2/04 ,  A61N5/00

CPC分类号： A61N2/02 ,  Y10T29/49071

摘要： A PEMF contoured triangular transducer system (FIG. 1a-1b) used for PEMF therapy (such as after spinal fusion) uses a two-transducer configuration for generating flux-aided electromagnetic fields. The semi-rigid transducers (12, 14) are conformable to a selected anatomical contour, and incorporated with an adjustable belt (16) to provide bracing. The belt includes compartments for a drive electronics module (22), and a rechargeable battery pack (24), making the system portable. The drive electronics (FIG. 3) includes a PEMF processor (41) that executes a PEMF program for providing pulsing current to the front and back transducers at predetermined intervals, thereby activating the electromagnetic field according to a prescribed PEMF regimen.

摘要翻译： 用于PEMF治疗（例如脊柱融合之后）的PEMF轮廓三角换能器系统（图1a-1b）使用双换能器配置来产生助焊电磁场。 半刚性换能器（12,14）符合选定的解剖轮廓，并结合有可调节带（16）以提供支撑。 带包括用于驱动电子模块（22）的隔间和可再充电电池组（24），使系统可移动。 驱动电子装置（图3）包括PEMF处理器（41），该PEMF处理器执行PEMF程序，用于以预定的间隔向前后的换能器提供脉冲电流，从而根据规定的PEMF方案激活电磁场。

公开(公告)号：US09533164B2

公开(公告)日：2017-01-03

申请号：US12245208

申请日：2008-10-03

申请人： John H. Erickson ,  Robert L. McCormick ,  Benjamin A. Tranchina

发明人： John H. Erickson ,  Robert L. McCormick ,  Benjamin A. Tranchina

IPC分类号： A61N1/378

CPC分类号： A61N1/378 ,  A61N1/3787

摘要： In one embodiment, a method of operating an implantable pulse generator comprises: providing power to a voltage converter at a first voltage level; outputting a second voltage level by the voltage converter, the second voltage level being a variable voltage level that is controlled by a control signal provided to the voltage converter, the second voltage level being provided to pulse generating circuitry of the implantable pulse generator, the second voltage level being selectable from a plurality of voltages including non-integer multiples of the first voltage level; generating pulses by the pulse generating circuitry, the pulse generating circuitry including current control circuitry for controlling the pulses to cause the pulses to provide substantially constant current to tissue of the patient; and applying at least two different control signals to the voltage converter during individual pulses to provide successively increasing voltages to the pulse generating circuitry during a respective pulse.

摘要翻译： 在一个实施例中，一种操作可植入脉冲发生器的方法包括：在第一电压电平下向电压转换器供电; 由所述电压转换器输出第二电压电平，所述第二电压电平是由提供给所述电压转换器的控制信号控制的可变电压电平，所述第二电压电平被提供给所述可植入脉冲发生器的脉冲发生电路，所述第二电压电平 电压电平可从包括第一电压电平的非整数倍的多个电压中选择; 由脉冲发生电路产生脉冲，脉冲发生电路包括电流控制电路，用于控制脉冲以使脉冲向患者的组织提供基本恒定的电流; 以及在单个脉冲期间将至少两个不同的控制信号施加到所述电压转换器，以在相应脉冲期间向所述脉冲发生电路提供连续增加的电压。